ID A0A1S3BUF6_CUCME Unreviewed; 351 AA.
AC A0A1S3BUF6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Histone deacetylase 2 {ECO:0000313|RefSeq:XP_008452709.1};
GN Name=LOC103493650 {ECO:0000313|RefSeq:XP_008452709.1};
OS Cucumis melo (Muskmelon).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis.
OX NCBI_TaxID=3656 {ECO:0000313|Proteomes:UP000089565, ECO:0000313|RefSeq:XP_008452709.1};
RN [1] {ECO:0000313|Proteomes:UP000089565}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DHL92 {ECO:0000313|Proteomes:UP000089565};
RX PubMed=22753475; DOI=10.1073/pnas.1205415109;
RA Garcia-Mas J., Benjak A., Sanseverino W., Bourgeois M., Mir G.,
RA Gonzalez V.M., Henaff E., Camara F., Cozzuto L., Lowy E., Alioto T.,
RA Capella-Gutierrez S., Blanca J., Canizares J., Ziarsolo P.,
RA Gonzalez-Ibeas D., Rodriguez-Moreno L., Droege M., Du L.,
RA Alvarez-Tejado M., Lorente-Galdos B., Mele M., Yang L., Weng Y.,
RA Navarro A., Marques-Bonet T., Aranda M.A., Nuez F., Pico B., Gabaldon T.,
RA Roma G., Guigo R., Casacuberta J.M., Arus P., Puigdomenech P.;
RT "The genome of melon (Cucumis melo L.).";
RL Proc. Natl. Acad. Sci. U.S.A. 109:11872-11877(2012).
RN [2] {ECO:0000313|RefSeq:XP_008452709.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
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DR RefSeq; XP_008452709.1; XM_008454487.2.
DR AlphaFoldDB; A0A1S3BUF6; -.
DR GeneID; 103493650; -.
DR KEGG; cmo:103493650; -.
DR eggNOG; KOG1344; Eukaryota.
DR InParanoid; A0A1S3BUF6; -.
DR OrthoDB; 239005at2759; -.
DR Proteomes; UP000089565; Unplaced.
DR GO; GO:0004407; F:histone deacetylase activity; IEA:UniProtKB-EC.
DR CDD; cd09993; HDAC_classIV; 1.
DR Gene3D; 3.40.800.20; Histone deacetylase domain; 1.
DR InterPro; IPR044150; HDAC_classIV.
DR InterPro; IPR000286; His_deacetylse.
DR InterPro; IPR023801; His_deacetylse_dom.
DR InterPro; IPR037138; His_deacetylse_dom_sf.
DR InterPro; IPR023696; Ureohydrolase_dom_sf.
DR PANTHER; PTHR10625:SF33; HISTONE DEACETYLASE 11; 1.
DR PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR Pfam; PF00850; Hist_deacetyl; 1.
DR PRINTS; PR01270; HDASUPER.
DR SUPFAM; SSF52768; Arginase/deacetylase; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Reference proteome {ECO:0000313|Proteomes:UP000089565};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 53..330
FT /note="Histone deacetylase"
FT /evidence="ECO:0000259|Pfam:PF00850"
SQ SEQUENCE 351 AA; 38946 MW; 2E1F0024E4659261 CRC64;
MSSSLSPNAN NGETVRRDRI LSSKLYFDVP SSKVPVIYSS SYDISFLGIE KLHPFDSKKW
GRVCQFLIAA GVLRKDQIIE PLEAKKNDLL VVHPESYLNS LKNSSNVAKI IEVPPVALFP
HCVVKEKVQR PFRNQVGGSI LAGKVAKEKG WAINVGGGFH HCSAEQGGGF CVYADISLCI
HYAFVQLNIS RVMIIDLDAH QGNGHEMDFA HDRRVYILDM FNPGIYPFDY EARRCIDQKV
EVVSGTTTSE YLKKLDEALE VAATSYDPEL IVYNAGTDIL DGDPLGLLKI SAEGIAKRDE
KVFRFARARN IPIVMLTSGG YMKSSAKVIA DSIENLSKQR LIDTESSPDR M
//
