ID A0A1S3H612_LINUN Unreviewed; 752 AA.
AC A0A1S3H612;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Protein VAC14 homolog {ECO:0000256|ARBA:ARBA00013840};
GN Name=LOC106152413 {ECO:0000313|RefSeq:XP_013381422.1,
GN ECO:0000313|RefSeq:XP_013381423.1, ECO:0000313|RefSeq:XP_013381424.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|RefSeq:XP_013381422.1};
RN [1] {ECO:0000313|RefSeq:XP_013381422.1, ECO:0000313|RefSeq:XP_013381423.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013381422.1,
RC ECO:0000313|RefSeq:XP_013381423.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Microsome membrane
CC {ECO:0000256|ARBA:ARBA00004524}.
CC -!- SIMILARITY: Belongs to the VAC14 family.
CC {ECO:0000256|ARBA:ARBA00010225}.
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DR RefSeq; XP_013381422.1; XM_013525968.2.
DR RefSeq; XP_013381423.1; XM_013525969.2.
DR RefSeq; XP_013381424.1; XM_013525970.2.
DR STRING; 7574.A0A1S3H612; -.
DR EnsemblMetazoa; XM_013525968.2; XP_013381422.1; LOC106152413.
DR EnsemblMetazoa; XM_013525969.2; XP_013381423.1; LOC106152413.
DR EnsemblMetazoa; XM_013525970.2; XP_013381424.1; LOC106152413.
DR GeneID; 106152413; -.
DR KEGG; lak:106152413; -.
DR OrthoDB; 5481081at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0070772; C:PAS complex; IEA:InterPro.
DR GO; GO:0006661; P:phosphatidylinositol biosynthetic process; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 3.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR026825; Vac14.
DR InterPro; IPR021841; VAC14_Fig4p-bd.
DR PANTHER; PTHR16023:SF0; PROTEIN VAC14 HOMOLOG; 1.
DR PANTHER; PTHR16023; TAX1 BINDING PROTEIN-RELATED; 1.
DR Pfam; PF12755; Vac14_Fab1_bd; 1.
DR Pfam; PF11916; Vac14_Fig4_bd; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 514..691
FT /note="Vacuolar protein 14 C-terminal Fig4-binding"
FT /evidence="ECO:0000259|Pfam:PF11916"
FT REGION 343..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 729..752
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..364
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 752 AA; 84703 MW; 64DF238F5C38D716 CRC64;
MNEKDFAPLT AACVRALNDK LYEKRKGAAL EIERQVREYV ATNNREEITR VLQVLGGKDF
STSQNPNGRK GGLIGMAATA IALGKESSLY VREMVKPTLA CFYDQDGRVR YYACEALYNI
VKVARGSVLP LFNDIFDGLS KLAADPDQNV KNGSELLDRL VKDIVTESSS FDLVSFMPLL
RDRIYVRNAF ARQFLVSWIS TLDAVPDIEM IVFLPEILDG LFNILGDEND EIRKMCEACL
GEFLQGIHKE RSKADFAAMA NVLVMHSQSK DPLIQHTALL WLKDFLQLSG RVILPYASGI
ITAVLPCLAY DASRKNTLEV AKIVNSNMIS LIAAEADAGA QSAEQKVHST GGKDEVKEGT
KSETESAATK VATRTGVFTF SKVQGVSDDL LLDVGAVVRV LMKYLSHEAI ATREASLRWI
YHLLQKTPEK MFCFVDDFFP LLMKTLSDPS DEVVLLDLEV LTEVSSNPAG NNITLNYEEM
GLPSQAKVTK PTGLSAYFVK FMVILLDSFN KDKQLLEDRG SFIIRQLCLM LNAEAIYRSF
SEILLHENDL RFACHMVQTL NIILLTSTEL FDLRNLLKDL KNEESCSLFC CLYHTWCHSP
VATVSLCFLT QNYEHASNVL LLFGDVEVTV EFLAEIDKLV QLIESPIFTY LRLQLLDPQL
NQSLITSLYA LLMLLPQGDA FRTLRHRLEC VPSFQYQVEK KTISGTKSKK TTKSIDFKKL
LEIFRDTQEK HRMSKKTTRR KETARQLKID KV
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