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Database: UniProt/TrEMBL
Entry: A0A1S3IS89_LINUN
LinkDB: A0A1S3IS89_LINUN
Original site: A0A1S3IS89_LINUN 
ID   A0A1S3IS89_LINUN        Unreviewed;       660 AA.
AC   A0A1S3IS89;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   25-OCT-2017, entry version 6.
DE   RecName: Full=Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial {ECO:0000256|RuleBase:RU362051};
DE            EC=1.3.5.1 {ECO:0000256|RuleBase:RU362051};
GN   Name=LOC106166829 {ECO:0000313|RefSeq:XP_013400938.1};
OS   Lingula unguis.
OC   Eukaryota; Metazoa; Lophotrochozoa; Brachiopoda; Linguliformea;
OC   Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX   NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013400938.1};
RN   [1] {ECO:0000313|RefSeq:XP_013400938.1}
RP   IDENTIFICATION.
RC   TISSUE=Gonads {ECO:0000313|RefSeq:XP_013400938.1};
RG   RefSeq;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- FUNCTION: Flavoprotein (FP) subunit of succinate dehydrogenase
CC       (SDH) that is involved in complex II of the mitochondrial electron
CC       transport chain and is responsible for transferring electrons from
CC       succinate to ubiquinone (coenzyme Q).
CC       {ECO:0000256|RuleBase:RU362051}.
CC   -!- CATALYTIC ACTIVITY: Succinate + a quinone = fumarate + a quinol.
CC       {ECO:0000256|RuleBase:RU362051}.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|RuleBase:RU362051};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       fumarate from succinate (eukaryal route): step 1/1.
CC       {ECO:0000256|RuleBase:RU362051}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000256|RuleBase:RU362051}; Peripheral membrane protein
CC       {ECO:0000256|RuleBase:RU362051}; Matrix side
CC       {ECO:0000256|RuleBase:RU362051}.
CC   -!- SIMILARITY: Belongs to the FAD-dependent oxidoreductase 2 family.
CC       FRD/SDH subfamily. {ECO:0000256|RuleBase:RU362051}.
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DR   RefSeq; XP_013400938.1; XM_013545484.1.
DR   EnsemblMetazoa; g11621.t1; g11621.t1; g11621.
DR   GeneID; 106166829; -.
DR   UniPathway; UPA00223; UER01006.
DR   Proteomes; UP000085678; Genome assembly.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0008177; F:succinate dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0022900; P:electron transport chain; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.20.58.100; -; 1.
DR   Gene3D; 3.50.50.60; -; 2.
DR   InterPro; IPR003953; FAD-binding_2.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR003952; FRD_SDH_FAD_BS.
DR   InterPro; IPR037099; Fum_R/Succ_DH_flav-like_C_sf.
DR   InterPro; IPR015939; Fum_Rdtase/Succ_DH_flav-like_C.
DR   InterPro; IPR027477; Succ_DH/fumarate_Rdtase_cat.
DR   InterPro; IPR011281; Succ_DH_flav_su_fwd.
DR   InterPro; IPR014006; Succ_Dhase_FrdA_Gneg.
DR   Pfam; PF00890; FAD_binding_2; 1.
DR   Pfam; PF02910; Succ_DH_flav_C; 1.
DR   SUPFAM; SSF46977; SSF46977; 1.
DR   SUPFAM; SSF51905; SSF51905; 2.
DR   SUPFAM; SSF56425; SSF56425; 1.
DR   TIGRFAMs; TIGR01816; sdhA_forward; 1.
DR   TIGRFAMs; TIGR01812; sdhA_frdA_Gneg; 1.
DR   PROSITE; PS00504; FRD_SDH_FAD_BINDING; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000085678};
KW   Electron transport {ECO:0000256|RuleBase:RU362051};
KW   FAD {ECO:0000256|RuleBase:RU362051};
KW   Flavoprotein {ECO:0000256|RuleBase:RU362051};
KW   Membrane {ECO:0000256|RuleBase:RU362051};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU362051};
KW   Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW   Transit peptide {ECO:0000256|RuleBase:RU362051};
KW   Transport {ECO:0000256|RuleBase:RU362051};
KW   Tricarboxylic acid cycle {ECO:0000256|RuleBase:RU362051};
KW   Ubiquinone {ECO:0000313|RefSeq:XP_013400938.1}.
FT   DOMAIN       58    453       FAD_binding_2. {ECO:0000259|Pfam:
FT                                PF00890}.
FT   DOMAIN      508    660       Succ_DH_flav_C. {ECO:0000259|Pfam:
FT                                PF02910}.
SQ   SEQUENCE   660 AA;  72355 MW;  C07CD55FAFCA801E CRC64;
     MAAVLKVSSQ LVKNIAIKTP IASTSTATRK LHFGPSVNTD VKTGQISKDY QVIDHTYDAV
     VVGAGGAGLR AAFGLANQGF KTACISKLFP TRSHTVAAQG GINAALGNME EDDWKWHMYD
     TVKGSDWLGD QDAIHYMTEE APKAVIELEN YGMPFSRLEN GKIYQRAFGG QSLKYGKGGQ
     AHRCCCVADR TGHSLLHTLY GRSLKYDTNY FIEYFALDLL MEDGECRGVL AFCLEDGSLH
     RIKAKNTILA TGGYGRSYFS CTSAHTCTGD GTAMVARAGL ANEDMEFVQF HPTGIYGAGC
     LITEGCRGEG GFLINGNGER FMERYAPSAK DLASRDVVSR SMTIEMREGR GCGPNKDYIY
     LQLHHLPPNI LSTRLPGISE TAMIFAGVDV TREPIPVLPT VHYNMGGVPT NYKGQVVQYT
     EEKGDYIVPG LYACGEAACA SVHGANRLGA NSLLDLVVFG RACALTIAEE NKPGEPIGDL
     SANSGEASVA NIDKLRHANG STPTAELRLQ MQKDMQNHAA VFRDGPVLKE GCRKLDAEWK
     QMDDLKVSDK SLIWNTDLVE TLELQNLMIN SLETIYGAEA RTESRGAHSR EDFKERVDEY
     DYSKPLVGQT PKPLKDHWRK HTLSYVDNDT GKVRLDYRPV IDSTLDEQKV PNVPPAIRSY
//
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