GenomeNet

Database: UniProt/TrEMBL
Entry: A0A1S3M2V5_SALSA
LinkDB: A0A1S3M2V5_SALSA
Original site: A0A1S3M2V5_SALSA 
ID   A0A1S3M2V5_SALSA        Unreviewed;      3096 AA.
AC   A0A1S3M2V5;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   25-OCT-2017, entry version 7.
DE   RecName: Full=Histone-lysine N-methyltransferase {ECO:0000256|SAAS:SAAS00591749};
DE            EC=2.1.1.43 {ECO:0000256|SAAS:SAAS00591749};
GN   Name=LOC106570093 {ECO:0000313|RefSeq:XP_013997552.1,
GN   ECO:0000313|RefSeq:XP_013997553.1, ECO:0000313|RefSeq:XP_013997554.1,
GN   ECO:0000313|RefSeq:XP_013997556.1};
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii;
OC   Salmoniformes; Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013997553.1};
RN   [1] {ECO:0000313|RefSeq:XP_013997552.1, ECO:0000313|RefSeq:XP_013997553.1, ECO:0000313|RefSeq:XP_013997554.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_013997552.1,
RC   ECO:0000313|RefSeq:XP_013997553.1};
RG   RefSeq;
RL   Submitted (JUN-2017) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] =
CC       S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
CC       {ECO:0000256|SAAS:SAAS00591578}.
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DR   RefSeq; XP_013997552.1; XM_014142077.1.
DR   RefSeq; XP_013997553.1; XM_014142078.1.
DR   RefSeq; XP_013997554.1; XM_014142079.1.
DR   RefSeq; XP_013997556.1; XM_014142081.1.
DR   GeneID; 106570093; -.
DR   KEGG; sasa:106570093; -.
DR   KO; K06101; -.
DR   Proteomes; UP000087266; Genome assembly.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.920.10; -; 1.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR017956; AT_hook_DNA-bd_motif.
DR   InterPro; IPR006560; AWS_dom.
DR   InterPro; IPR001025; BAH_dom.
DR   InterPro; IPR001487; Bromodomain.
DR   InterPro; IPR036427; Bromodomain-like_sf.
DR   InterPro; IPR018359; Bromodomain_CS.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR019787; Znf_PHD-finger.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF01426; BAH; 1.
DR   Pfam; PF00439; Bromodomain; 1.
DR   Pfam; PF00628; PHD; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00384; AT_hook; 6.
DR   SMART; SM00570; AWS; 1.
DR   SMART; SM00439; BAH; 1.
DR   SMART; SM00249; PHD; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF47370; SSF47370; 1.
DR   SUPFAM; SSF57903; SSF57903; 1.
DR   PROSITE; PS51215; AWS; 1.
DR   PROSITE; PS51038; BAH; 1.
DR   PROSITE; PS00633; BROMODOMAIN_1; 1.
DR   PROSITE; PS50014; BROMODOMAIN_2; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50280; SET; 1.
DR   PROSITE; PS01359; ZF_PHD_1; 1.
PE   4: Predicted;
KW   Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035};
KW   Complete proteome {ECO:0000313|Proteomes:UP000087266};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00591173};
KW   Methyltransferase {ECO:0000256|SAAS:SAAS00590675,
KW   ECO:0000313|RefSeq:XP_013997552.1, ECO:0000313|RefSeq:XP_013997553.1,
KW   ECO:0000313|RefSeq:XP_013997554.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW   S-adenosyl-L-methionine {ECO:0000256|SAAS:SAAS00591079};
KW   Transferase {ECO:0000256|SAAS:SAAS00591533,
KW   ECO:0000313|RefSeq:XP_013997552.1, ECO:0000313|RefSeq:XP_013997553.1,
KW   ECO:0000313|RefSeq:XP_013997554.1};
KW   Zinc {ECO:0000256|SAAS:SAAS00592951};
KW   Zinc-finger {ECO:0000256|SAAS:SAAS00592111}.
FT   DOMAIN     2168   2219       AWS. {ECO:0000259|PROSITE:PS51215}.
FT   DOMAIN     2222   2338       SET. {ECO:0000259|PROSITE:PS50280}.
FT   DOMAIN     2346   2362       Post-SET. {ECO:0000259|PROSITE:PS50868}.
FT   DOMAIN     2547   2617       Bromo. {ECO:0000259|PROSITE:PS50014}.
FT   DOMAIN     2754   2891       BAH. {ECO:0000259|PROSITE:PS51038}.
SQ   SEQUENCE   3096 AA;  340697 MW;  E56E6B4D3D8ADD14 CRC64;
     MDQRTQGGPA TPPPLPITAP QGEREKEGGG GKKDEEEKEI EGPQKDSSSA AGGEGSGDQQ
     QSPQFSVKET SLHEGNVKLK IGLQAKRMKK PPKILENYVC RPAFRATVRP SGRGGGRGSR
     GGVGAGDGVN QTQSPTHGRE REQSPGIKRP TPPSSSPSAV AAPTPPPPVS SSSTTSPIRV
     NGSTPAKRGP PKLACKSDKS VAMSDGKSAI STERPLNLHR PSADGKMHHA SGKKMPMPQT
     KSPTSSPSPL EPLSQEPSVE GVTNPPGYIY SSEGLEEKDR GVPSWGAPTV TEKLAQLIAI
     CPPSKSTKVK PPKTTPSPTT HTTSNFMAPT PKQRDRAMVN RATYSRAVHL APPPPVSRPP
     GRPYGSRNNK DCVSEKSPTP RGKEEADGAG KSGSSNDSNS SRSSSPVLTY AGGNSRLATT
     SKDNNDSNSN GTTPPQSRLT HCPPPHSASS SSSSSPSCLS SCSSSEKRTG SLSCRQGSQA
     SQGHHSRDRE SPSQAEERDS SERDSSERDS SERDRHCPRD ISKCPPPSAS GKQESKTKGA
     NQSLRGERSK SLSPSKRSPN PSKRSPNPSK RSPNPSKRSP NPSKRSPNPS IRSPNPSIRS
     PNPSIRSPNP SIRSPNPSIR SPNPSIRSPN PSIRSPNPSI RSPNPSIRSP NPSIRSPNPS
     IRSPNPSIRS PNPSIRSPNP SIRSPNPSIR SPNPSIRSPN PSIRSPNRER DGRTSGIFSP
     LEAVRRTASP PEPAGDRSPP PLRDESPGEE SPGSPPGQDN KPLKKRRGRK PRWTRIVNRS
     QRAGQGSPVD QRETIVPLSS GLDTSPPIRR PVGRPPNPNK VKPSTVSQLF PQPARKRGRP
     KSKMPRLDAP TRGRPPHKLV PSKVFSSQKS KEEQDPPVLH PEVDLNPPKP MPRKRGRPKR
     LPPTLPQEGQ PPTLAPEGGD GKQFRSKGNG QLIMKTIIGK INKMKSVKRK RFLSQILLGP
     GSGPEQEPPR GTASGVVGQV AAATQSLSSL AASFGGKLGP QINVSKKGTI YMGKRRGRKP
     KASTNPSVAA STTPPERPFL SPNTTPPPYH HLSQSQQQHH HLPTAEVFPS PSLSQSSGGQ
     SPISDACFVE PGAVHFLTHP HFHSHHVHHS FPFPPPTFSA PSPRALVSSA AVASQKKSCR
     GYHHHHHHYR QHYHYRKLSP PTPLHPTSPA PLSELKEATP SPVSESHSEE TVPSDSGIGT
     DNNSTSDRGE KACGVGMPPG MASGLLMPGV MGSAVGVGVG QNPHGGLRHS SSVLLEHPSS
     SPSPLGVRSS PDPRRPHPAA PPSALVGHKE KHKHKCKRRS HGCPGYDKLK RQKRKRKKKY
     LQLRSRRQDP DFLAELDEIV LRLSEIRIAH RTPAHRLGSG LGMPPGAAGA SRVPGSGGRA
     AGTMGGAGGP PPHHYLHRDL LPTIFRINFS GYYSPHPSYP CDSLHYVRKP DLKKKRGRPP
     KLRESLSDVP FVHGLGFPLS SGGFYHPSYS VPYSSGPLGL GYYRGYPPAS ALYPHHQNPL
     SAPSHHSHHS PSFHPPPPPS YVHHHHPSHL LLNPSKFHKK KHKLLRQEFL GGGRSPVLYP
     TMSSELSFGW HHKHKHRHKH RERCAEEDGE EGGGGSRGGV GMTESPGSGR GEHGASGAGM
     AESLQRCRFG RDSTPTTTSA NNQATANSPS SSSSSSAERY KRKETSLSCL GPSRLTQGSA
     GPRGHHPVES WFRMGSSEAD YAKLSRIPAG ADQGPFTEGQ GEDPAGCSDS EDEDEEPLTP
     TDEMDPNSQD PPHHTNLFAT ALTSTSLRGV GGRKGVAAES ANFSRMELML KKDHSTSAER
     RELGNTSGVQ TRGDHSAPED HLMQHHNHHP LFHSLSSSSA CLSHCGHDSP SQGCCLDKDA
     SPQNHSHRAQ PSKHSLHHVN KILRAKKLQR QARTGNNVVK KRGPGRPRKH PLPSPPPSLP
     PPAEVTQTRH RDRGGGSGGG ACKEDTVTDA IESVVQGQRR KGQKRNHWER DEDEEKEEGE
     GEEVGEGEEV EERALDREVN LGGLGMRSRA GGGRDWLTQE ELQRFRSALE GKPDGPSSPE
     PPGTVSMEQA PPMPITSLRE KRAARPPKKK YQKAGLYSDV YKTADPRSQI LQLKKEKLEY
     TPGEHEYGLF PAPIHVGKYL RQKRIDFQLP YDILWLWKHD QLYEKPDVPL YKKIRSNVYV
     DVKPVSGYEA TTCNCRPSGE AVDRGCLDEC LNRMSFAECS PGTCPCAEQC DNQHIQRHEW
     VQCLERFRAE GKGWGIRTKE PLRSGQFIIE YLGEVVSEHE FRSRMMEQYF AHSGQYCLNL
     DSGMVIDSYR MGNEARFINH SCEPNCEMQK WSVNGVYRIG LFALRDMSSG TELTYDYNFH
     SFNTEEQQVC KCGSEGCRGI IGGKSQRING MPGKTGGARR LGRLKEKRKS KHQLKKRVRV
     RERGSETGGN VREKKEEESS DSSKFYPHLL MKPMSNRERN FVLKHRVFLL RNWEKMREKQ
     ELLKREGERE ASGGLSIYTR WGGVIRDDGN IKSDVFLTQF SALQTSRSVR TRRLAAAEEN
     TEVTRTARLA HIFKEICDMI TSYKDSAGQT LAAPLVNLPS RKRNTQYYEK VSDPLDLSTI
     EKQITTGHYK TVEAFDTDML KVFRNAEKYY GRKSSVGRDV CRLRKAYYGA RHEAAVQIDE
     IVGETASEAD SSDSLERDHT HHHHGGGWPG SHDKDDDIIR CICGMYKDEG LMIQCEKCMV
     WQHFDCMRLE AEVEHYLCDQ CDPRPVDREV PMLPQPSYAQ SGSIYHICLL RDELLLHQGD
     CVYLMRDSRR TPEGQPVRQS YRLLSHVNRD KLDIFRIEKL WKSEKGERFA FGHHYFRPHE
     THHSPSRRFY HNELFRVPLY EIIPLEAVVG TCCVLDLYTY CKGRPKGVKE QDVYICDYRL
     DKSAHLFYKI HRNRFPVCTK PYAFNHFPKR LAPKRDFSPH YVPDNYKRNG GRSAWKSERP
     KGVGGACEDD ASPCDQGDNF HPASENGKGV EGDMDAAQEE TTLPAAAQPP QPVGPGEGEE
     EEGGQEVEEH RELEEGAAER GVDMLELLPS MSSSPLHHSG LGRREAQRDR LNKILLDLLH
     RTPNKNAIDV TYLLEEGSGR RLRRRTLGFG DFVGRK
//
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