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Database: UniProt/TrEMBL
Entry: A0A1S3X1E4_TOBAC
LinkDB: A0A1S3X1E4_TOBAC
Original site: A0A1S3X1E4_TOBAC 
ID   A0A1S3X1E4_TOBAC        Unreviewed;      1151 AA.
AC   A0A1S3X1E4;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   25-OCT-2017, entry version 6.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   Name=LOC107760230 {ECO:0000313|RefSeq:XP_016433737.1};
OS   Nicotiana tabacum (Common tobacco).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
OC   Pentapetalae; asterids; lamiids; Solanales; Solanaceae;
OC   Nicotianoideae; Nicotianeae; Nicotiana.
OX   NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016433737.1};
RN   [1] {ECO:0000313|Proteomes:UP000084051}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX   PubMed=24807620; DOI=10.1038/ncomms4833;
RA   Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA   Goepfert S., Peitsch M.C., Ivanov N.V.;
RT   "The tobacco genome sequence and its comparison with those of tomato
RT   and potato.";
RL   Nat. Commun. 5:3833-3833(2014).
RN   [2] {ECO:0000313|RefSeq:XP_016433737.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (JUN-2017) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000256|RuleBase:RU000617}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
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DR   RefSeq; XP_016433737.1; XM_016578251.1.
DR   GeneID; 107760230; -.
DR   KEGG; nta:107760230; -.
DR   KO; K10777; -.
DR   Proteomes; UP000084051; Genome assembly.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd00027; BRCT; 1.
DR   Gene3D; 1.10.3260.10; -; 1.
DR   Gene3D; 3.40.50.10190; -; 2.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR029710; LIG4.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR10459:SF7; PTHR10459:SF7; 1.
DR   Pfam; PF16589; BRCT_2; 1.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SMART; SM00292; BRCT; 1.
DR   SUPFAM; SSF117018; SSF117018; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF52113; SSF52113; 2.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS50172; BRCT; 2.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS00333; DNA_LIGASE_A2; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   Complete proteome {ECO:0000313|Proteomes:UP000084051};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617,
KW   ECO:0000313|RefSeq:XP_016433737.1};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617};
KW   Reference proteome {ECO:0000313|Proteomes:UP000084051}.
FT   DOMAIN      343    475       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
FT   DOMAIN      648    736       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   DOMAIN      837    907       BRCT. {ECO:0000259|PROSITE:PS50172}.
SQ   SEQUENCE   1151 AA;  130036 MW;  A824FC72FF8DB4D2 CRC64;
     MATSAVDGGG SSIGGEDIKF SVMVSLFQWI QKSKSSAQKR SKFRKFLDAF CRKPQDNFAA
     MRLILPGLDR ERGSYGLKEH VLATCLIDAL AMSRDSDDAR RLLNWRKGGP KTGSNAGNFS
     LVAAEVLQRR QGMASAGLTI KELNEFLDHL ASSENRAEKT SILSDLIRKT NAQEMKWIIM
     IILKDLKLGI SEKSIFHEFH PDAEDLFNVT CDLKLVCEKL RDRSQRHKHQ DIEVGKAVRP
     QLALRVSNAS AAWKKLHGKE VVVECKFDGD RIQIHKNNSD LNFFSRNFFD HQEYAHGMSD
     VITQNILVNK CILDGEMLVW DASMNRFAEF GSNQEIAKAA REGLDSDRQL CYIAFDILYV
     GDTSVIHRSL KERQEILQKV VKPIKGRLEI LVPNGGLNAH RPSGKDALRF NRDEGIVLKD
     LTSKWEPSDR SGKWLKLKPE YVRAGSDLDV LIIGGYYGSG RHGGEVAQFL VGLAERPAPN
     TYPRRFISFC RVGTGVSDEE RNTIVTRLKP YFRKYEYPKQ APPTFYQVTN NAKERPDVWV
     ESPEKSIIVS ITSDIRTIRT EVFAAPYSLR FPRIDRVRYE KPWHECLDVQ SFVDLVHSSN
     GTTQREADYG VGQDHEPKAI RSSRKRGKKN VSAVPSHFVQ TDVSHIKGET SVFSNMVFYF
     ANVPSSHTLD SMHKMVVEHG GSFSMNLNNS VTHCIAAENR GIKFQAAKLH GDVIHCSWLF
     DCCLQKRLLP LQPKYFLFLS DSTKRKLEAE VDEYCDSFYS DLSVKDIRKL LSDIERSEDS
     KTVEYYKKKY CPKDKWARFH GCCIYFFIPE QCLKYSDCKA LVELATRRMK VEISVGGGKV
     GDNLCHVTHV VVMSLPDFDV NFSEVLNSFS EAEKHVLYNT KLHVVRASWL EDFFKEDRKL
     HEDSYSLKPS NFQMSISEKR HDKVRGKAVK CKRASSPDNH GVQIKAEGIS EQCQAITLPK
     GDRKRNRLRP TGTATAKAKP AINMPWRVRR KATNRRAKIH ENESDESATS GEHLHNDESE
     GAAGTRGSPE NVGEHGSGIQ NKDVADDLEL SPHGETFPQG TSECSRSRER LDEAHETSYE
     SANIASGKLE DPVDPVQAML LHMIPQLDGK PSHSVDSLVK DDKPEADANP SPKKKKKVSY
     KDVAGELLKD W
//
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