ID   A0A1S3ZP91_TOBAC        Unreviewed;       545 AA.
AC   A0A1S3ZP91;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=alanine transaminase {ECO:0000256|ARBA:ARBA00026106};
DE            EC=2.6.1.2 {ECO:0000256|ARBA:ARBA00026106};
GN   Name=LOC107788950 {ECO:0000313|RefSeq:XP_016466182.1};
OS   Nicotiana tabacum (Common tobacco).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC   Nicotiana.
OX   NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016466182.1};
RN   [1] {ECO:0000313|Proteomes:UP000084051}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX   PubMed=24807620; DOI=10.1038/ncomms4833;
RA   Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA   Goepfert S., Peitsch M.C., Ivanov N.V.;
RT   "The tobacco genome sequence and its comparison with those of tomato and
RT   potato.";
RL   Nat. Commun. 5:3833-3833(2014).
RN   [2] {ECO:0000313|RefSeq:XP_016466182.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933};
CC   -!- PATHWAY: Amino-acid degradation; L-alanine degradation via transaminase
CC       pathway; pyruvate from L-alanine: step 1/1.
CC       {ECO:0000256|ARBA:ARBA00025708}.
CC   -!- PATHWAY: Photosynthesis; C4 acid pathway.
CC       {ECO:0000256|ARBA:ARBA00025709}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC   -!- SIMILARITY: Belongs to the class-I pyridoxal-phosphate-dependent
CC       aminotransferase family. Alanine aminotransferase subfamily.
CC       {ECO:0000256|ARBA:ARBA00025785}.
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DR   RefSeq; XP_016466182.1; XM_016610696.1.
DR   AlphaFoldDB; A0A1S3ZP91; -.
DR   SMR; A0A1S3ZP91; -.
DR   STRING; 4097.A0A1S3ZP91; -.
DR   PaxDb; 4097-A0A1S3ZP91; -.
DR   GeneID; 107788950; -.
DR   KEGG; nta:107788950; -.
DR   OMA; CEFMDGL; -.
DR   OrthoDB; 5472891at2759; -.
DR   UniPathway; UPA00322; -.
DR   UniPathway; UPA00528; UER00586.
DR   Proteomes; UP000084051; Unplaced.
DR   GO; GO:0004021; F:L-alanine:2-oxoglutarate aminotransferase activity; IBA:GO_Central.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0042853; P:L-alanine catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR   CDD; cd00609; AAT_like; 1.
DR   Gene3D; 1.10.287.1970; -; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR045088; ALAT1/2-like.
DR   InterPro; IPR004839; Aminotransferase_I/II.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   PANTHER; PTHR11751; ALANINE AMINOTRANSFERASE; 1.
DR   PANTHER; PTHR11751:SF29; ALANINE TRANSAMINASE; 1.
DR   Pfam; PF00155; Aminotran_1_2; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE   3: Inferred from homology;
KW   Aminotransferase {ECO:0000313|RefSeq:XP_016466182.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000084051};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          169..525
FT                   /note="Aminotransferase class I/classII"
FT                   /evidence="ECO:0000259|Pfam:PF00155"
SQ   SEQUENCE   545 AA;  59715 MW;  81526D6E11D0279C CRC64;
     MRRFVADKAK NLITKTRTTY SSPSSSTTTC VLQRRTSSPQ SASVLRFLSI LHTAPSDSMA
     SDYSSTPVTL NNLNPKVLKC EYAVRGEIVN LAQKLHQDLK DNPGSHPFDE ILYCNIGNPQ
     SLAQQPITFF REVLALCDHP VILDKSETQG LFSADSIERA FQILDQIPGR ATGAYSHSQG
     VKGLRDTIAS GIEARDGFPA DPNDIFLTDG ASPAVHMMMQ LLIGSENDGI LCPIPQYPLY
     SASIALHGGT LVPYYLDEET GWGLEISELE NQLKTAKSKG IKVRALVVIN PGNPTGQVLA
     EANQRDIVKF CKKEGLVLLA DEVYQENVYV PEKQFHSFKK IARSMGFGEK DISLVSFQSV
     SKGFYGECGK RGGYMEVTGF SPEIREQIYK VASVNLCSNI SGQILASLVM SPPKVGDESY
     ESFSAEKEAI LSSLARRAKT LEDAFNSLEG VTCNKAEGAM YLFPRINLPA KAIKAAEEAK
     TAPDAFYARR LLNATGIVVV PGSGFGQRPG TWHFRCTILP QEEKIPAIVS SLTDFHKQFM
     DEFRG
//