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Database: UniProt/TrEMBL
Entry: A0A1U7VBU0_NICSY
LinkDB: A0A1U7VBU0_NICSY
Original site: A0A1U7VBU0_NICSY 
ID   A0A1U7VBU0_NICSY        Unreviewed;      1168 AA.
AC   A0A1U7VBU0;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   25-OCT-2017, entry version 5.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   Name=LOC104217038 {ECO:0000313|RefSeq:XP_009765492.1};
OS   Nicotiana sylvestris (Wood tobacco) (South American tobacco).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
OC   Pentapetalae; asterids; lamiids; Solanales; Solanaceae;
OC   Nicotianoideae; Nicotianeae; Nicotiana.
OX   NCBI_TaxID=4096 {ECO:0000313|Proteomes:UP000189701, ECO:0000313|RefSeq:XP_009765492.1};
RN   [1] {ECO:0000313|Proteomes:UP000189701}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23773524; DOI=10.1186/gb-2013-14-6-r60;
RA   Sierro N., Battey J.N., Ouadi S., Bovet L., Goepfert S., Bakaher N.,
RA   Peitsch M.C., Ivanov N.V.;
RT   "Reference genomes and transcriptomes of Nicotiana sylvestris and
RT   Nicotiana tomentosiformis.";
RL   Genome Biol. 14:R60-R60(2013).
RN   [2] {ECO:0000313|RefSeq:XP_009765492.1}
RP   IDENTIFICATION.
RC   TISSUE=Leaf {ECO:0000313|RefSeq:XP_009765492.1};
RG   RefSeq;
RL   Submitted (APR-2017) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000256|RuleBase:RU000617}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
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DR   RefSeq; XP_009765492.1; XM_009767190.1.
DR   GeneID; 104217038; -.
DR   Proteomes; UP000189701; Genome assembly.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd00027; BRCT; 1.
DR   Gene3D; 1.10.3260.10; -; 1.
DR   Gene3D; 3.40.50.10190; -; 2.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR029710; LIG4.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR10459:SF7; PTHR10459:SF7; 1.
DR   Pfam; PF16589; BRCT_2; 1.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SMART; SM00292; BRCT; 1.
DR   SUPFAM; SSF117018; SSF117018; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF52113; SSF52113; 2.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS50172; BRCT; 2.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS00333; DNA_LIGASE_A2; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   Complete proteome {ECO:0000313|Proteomes:UP000189701};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617,
KW   ECO:0000313|RefSeq:XP_009765492.1};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189701}.
FT   DOMAIN      343    492       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
FT   DOMAIN      665    753       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   DOMAIN      854    924       BRCT. {ECO:0000259|PROSITE:PS50172}.
SQ   SEQUENCE   1168 AA;  131869 MW;  E0EDA489DBA552D8 CRC64;
     MATSAVDGGG SSIGGEDIKF SVMVSLFQWI QKSKSSAQKR SKFRKFLDAF CRKPQDNFAA
     MRLILPGLDR ERGSYGLKEH VLATCLIDAL AMSRDSDDAR RLLNWRKGGP KTGSNAGNFS
     LVAAEVLQRR QGMASAGLTI KELNEFLDHL ASSENRAEKT SILSDLIRKT NAQEMKWIIM
     IILKDLKLGI SEKSIFHEFH PDAEDLFNVT CDLKLVCEKL RDRSQRHKHQ DIEVGKAVRP
     QLALRVSNAS AAWKKLHGKE VVVECKFDGD RIQIHKNNSD LNFFSRNFFD HQEYAHGMSD
     VITQNILVNK CILDGEMLVW DASMNRFAEF GSNQEIAKAA REGLDSDRQL CYIAFDILYV
     GDTSVIHRSL KERQEILQKV VKPIKGRLEI LVPNGGLNAH RPSGEPCWSI IAHSVDDVDK
     FFKETVENRD EGIVLKDLTS KWEPSDRSGK WLKLKPEYVR AGSDLDVLII GGYYGSGRHG
     GEVAQFLVGL AERPAPNTYP RRFISFCRVG TGVSDEERNT IVTRLKPYFR KYEYPKQAPP
     TFYQVTNNAK ERPDVWVESP EKSIIVSITS DIRTIRTEVF AAPYSLRFPR IDRVRYEKPW
     HECLDVQSFV DLVHSSNGTT QREADYGVGQ DHEPKAIRSS RKRGKKNVSA VPSHFVQTDV
     SHIKGETSVF SNMVFYFANV PSSHTLDSMH KMVVEHGGSF SMNLNNSVTH CIAAENRGIK
     FQAAKLHGDV IHCSWLFDCC LQKRLLPLQP KYFLFLSDST KRKLEAEVDE YCDSFYSDLS
     VKDIRKLLSD IERSEDSKTV EYYKKKYCPK DKWARFHGCC ICFFIPEQCL KYSDCKALVE
     LATRRMKVEI SVGGGKVGDN LCHVTHVVVM SLPDFDVNFS EVLNSFSEAE KHVLYNTKLH
     VVRASWLEDF FKEDRKLHED SYSLKPSNFQ MSISEKRHDK VRGKAVKCKR ASSPDNHGVQ
     IKAEGLSEQC QAITLPKGDR KRNRLRPTGT ATAKAKPAIN MPWRVRCKAT NRRAKIHENE
     SDESATSGEH LHNDESEGAA GTRGSPENVG EHGSGIQNKD VADDLELSPH GETFPQGTSE
     CSRSRERLDE AHETSYESAN IASGKLEDPV DPVQAMLLHM IPQLDGKPSH SVDSLVKDDK
     PEADANPSPK KKKKVSYKDV AGELLKDW
//
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