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Database: UniProt/TrEMBL
Entry: A0A1U7XZS5_NICSY
LinkDB: A0A1U7XZS5_NICSY
Original site: A0A1U7XZS5_NICSY 
ID   A0A1U7XZS5_NICSY        Unreviewed;       476 AA.
AC   A0A1U7XZS5;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   25-OCT-2017, entry version 5.
DE   RecName: Full=Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex {ECO:0000256|RuleBase:RU003423};
DE            EC=2.3.1.- {ECO:0000256|RuleBase:RU003423};
GN   Name=LOC104239158 {ECO:0000313|RefSeq:XP_009792010.1};
OS   Nicotiana sylvestris (Wood tobacco) (South American tobacco).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
OC   Pentapetalae; asterids; lamiids; Solanales; Solanaceae;
OC   Nicotianoideae; Nicotianeae; Nicotiana.
OX   NCBI_TaxID=4096 {ECO:0000313|Proteomes:UP000189701, ECO:0000313|RefSeq:XP_009792010.1};
RN   [1] {ECO:0000313|Proteomes:UP000189701}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23773524; DOI=10.1186/gb-2013-14-6-r60;
RA   Sierro N., Battey J.N., Ouadi S., Bovet L., Goepfert S., Bakaher N.,
RA   Peitsch M.C., Ivanov N.V.;
RT   "Reference genomes and transcriptomes of Nicotiana sylvestris and
RT   Nicotiana tomentosiformis.";
RL   Genome Biol. 14:R60-R60(2013).
RN   [2] {ECO:0000313|RefSeq:XP_009792010.1}
RP   IDENTIFICATION.
RC   TISSUE=Leaf {ECO:0000313|RefSeq:XP_009792010.1};
RG   RefSeq;
RL   Submitted (APR-2017) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC         Evidence={ECO:0000256|RuleBase:RU003423};
CC   -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU003423}.
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DR   RefSeq; XP_009792010.1; XM_009793708.1.
DR   GeneID; 104239158; -.
DR   Proteomes; UP000189701; Genome assembly.
DR   GO; GO:0016746; F:transferase activity, transferring acyl groups; IEA:UniProtKB-KW.
DR   GO; GO:0008152; P:metabolic process; IEA:InterPro.
DR   Gene3D; 4.10.320.10; -; 1.
DR   InterPro; IPR003016; 2-oxoA_DH_lipoyl-BS.
DR   InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR   InterPro; IPR000089; Biotin_lipoyl.
DR   InterPro; IPR004167; E3-bd.
DR   InterPro; IPR036625; E3-bd_dom_sf.
DR   InterPro; IPR011053; Single_hybrid_motif.
DR   Pfam; PF00198; 2-oxoacid_dh; 1.
DR   Pfam; PF00364; Biotin_lipoyl; 1.
DR   Pfam; PF02817; E3_binding; 1.
DR   SUPFAM; SSF47005; SSF47005; 1.
DR   SUPFAM; SSF51230; SSF51230; 1.
DR   PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR   PROSITE; PS00189; LIPOYL; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|RuleBase:RU003423};
KW   Complete proteome {ECO:0000313|Proteomes:UP000189701};
KW   Lipoyl {ECO:0000256|RuleBase:RU003423};
KW   Pyruvate {ECO:0000313|RefSeq:XP_009792010.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189701};
KW   Transferase {ECO:0000256|RuleBase:RU003423,
KW   ECO:0000313|RefSeq:XP_009792010.1}.
FT   DOMAIN       39    114       Lipoyl-binding. {ECO:0000259|PROSITE:
FT                                PS50968}.
SQ   SEQUENCE   476 AA;  49527 MW;  89662C8E608C0A1E CRC64;
     MSSHLLQTTF MPTTPIALRR ASIFPATHLR RTHVIESKIR EIFMPALSST MTEGKIVSWV
     KIEGDKLAKG EAVLVVESDK ADMDVESFYD GYLATIIVPE GGSAPVGSTI ALLAESEDEI
     ALAKAKTPIP TSTSSQETTT PAAAVSEEVV SPVAAAAGVS PSDAGPAKMA SAVHPASEGG
     KRVVASPYAK KLAKELGVEL RGLVGSGPNG RIVAKDVEAA VGSAASTPAP VGSVVGTTVA
     QPSGGAPVAP AVELGTTVPF TTMQNAVSRN MVESLAVPTF RVGYTITTNA LDALYKKIKS
     KGVTMTALLA KATALALAKH PVVNSSCRDG KSFTYNSSIN IAVAVAIDGG LITPVLQDAD
     KVDIYSLSRK WKELVDKARA KQLQPHEYTT GTFTLSNLGM FGVDRFDAIL PPGTGAIMAV
     GASHPALVGT KDGRIGLKNQ MQVNVTADHR VIYGADLASF LQTLAQIIED PKDLTL
//
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