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Database: UniProt/TrEMBL
Entry: A0A1U8MQR0_GOSHI
LinkDB: A0A1U8MQR0_GOSHI
Original site: A0A1U8MQR0_GOSHI 
ID   A0A1U8MQR0_GOSHI        Unreviewed;      1168 AA.
AC   A0A1U8MQR0;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   25-OCT-2017, entry version 6.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   Name=LOC107940281 {ECO:0000313|RefSeq:XP_016729206.1};
OS   Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
OC   Pentapetalae; rosids; malvids; Malvales; Malvaceae; Malvoideae;
OC   Gossypium.
OX   NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016729206.1};
RN   [1] {ECO:0000313|Proteomes:UP000189702}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX   PubMed=25893780; DOI=10.1038/nbt.3208;
RA   Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H.,
RA   Ma X., Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W.,
RA   Chen W., Du X., Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W.,
RA   Wei H., Wei S., Huang G., Zhang X., Zhu S., Zhang H., Sun F., Wang X.,
RA   Liang J., Wang J., He Q., Huang L., Wang J., Cui J., Song G., Wang K.,
RA   Xu X., Yu J.Z., Zhu Y., Yu S.;
RT   "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT   provides insights into genome evolution.";
RL   Nat. Biotechnol. 33:524-530(2015).
RN   [2] {ECO:0000313|RefSeq:XP_016729206.1}
RP   IDENTIFICATION.
RC   TISSUE=Leaf {ECO:0000313|RefSeq:XP_016729206.1};
RG   RefSeq;
RL   Submitted (APR-2017) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000256|RuleBase:RU000617}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
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DR   RefSeq; XP_016729206.1; XM_016873717.1.
DR   GeneID; 107940281; -.
DR   KEGG; ghi:107940281; -.
DR   KO; K10777; -.
DR   Proteomes; UP000189702; Genome assembly.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd00027; BRCT; 2.
DR   Gene3D; 1.10.3260.10; -; 1.
DR   Gene3D; 3.40.50.10190; -; 2.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR029710; LIG4.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR10459:SF7; PTHR10459:SF7; 2.
DR   Pfam; PF16589; BRCT_2; 1.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SMART; SM00292; BRCT; 2.
DR   SUPFAM; SSF117018; SSF117018; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF52113; SSF52113; 2.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS50172; BRCT; 2.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS00333; DNA_LIGASE_A2; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000189702};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617,
KW   ECO:0000313|RefSeq:XP_016729206.1};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189702}.
FT   DOMAIN      329    462       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
FT   DOMAIN      635    723       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   DOMAIN      781    893       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   COILED      125    148       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1168 AA;  133011 MW;  85F220D8D8906079 CRC64;
     MTEEIKLSVV VSLFTWIQRS RPSAKRSKFR KFLDTFCTPS DYFSAMRLIL PSLDRERGTY
     GLKESVLAIC LIDALGMSRD SADALRLINW RKGGANTGAN AGNFALVAAE VLQRRQGTVS
     GGLTIKELNE LLNRLASAES RAEKTAILAT LINKTNAQEM KWVIMIILKD LKLGISEKSI
     FQEFHPDAED LFNVTCDLKL VCEKLRDRTQ RHKRQDIEVG KAVRPQLALR VRDPAAAWKK
     LHGKEVVVEC KFDGDRIQIH KNGTDIHYYS RNFLDHSEYQ HGMSNIITQN ILVDRCILDG
     EMLVWDSTLN QFAEFGSNQE IAKAAKDGLD SDRQVLCYVA FDILYVGDTS VIHQSLKERH
     ELLQKVVKPL KGRLEILVPN GGLNAHRPPG RYTASYHLRD EGIVIKDLNS KWEPGDRNGK
     WLKLKPDYIR AGSDLDVLII GGYYGSGRRG GEVAQFLVGL ADRPDPNAYP RRFISFCRVG
     TGLTDDDLET VAKKLKPYFR KYEYPKKMQP SFYQVTNHSK ERPDVWIESP EKSIILSITS
     DIRTIRSEVF AAPYSLRFPR IDRVRYDKPW HECLGVQSFV ELVHSSNGTT QKGTEQENQP
     DSKTKHKAHA RKADKKNVSI VPSHFIRTDT SSVKGETLIF SNLMFYFVNV PPTYSLDSFH
     KMVVEHGGRF SMNLNNSVTH CVAAESKGIK YQAAKLHGDI IHYSWALGCC SQKKLIPLQP
     KYFLFLSESS KMKLQQEVDQ YFDPYYWDLD LVDVKRLLNN IQRSENSKTI DYYRAKYCPN
     DKWSLFHGCS VYFYSSAESL KADWQVLLNL ALRRLKHEIL MGGGKISENL SNATHLVVLS
     VPGLDVDFDS FIKSCSFEEK NLVWKKGLHV VRSQWLENCL EQGQKLREDQ YSLKPNDFEE
     INFVESKLDQ NLEKSKPDFN GVQNKGTCTS PESKTKQRGG KDHPEKSISS VTPSQPSHGN
     RKRRPASKNT KKGKTVVTRA QRVPRRRGKM SVKINEDGSE ESGSDDKTNE EIKKGEGYNT
     ECYRMAGREN FEFHQNQAAE ENASINWPKK AHDTVMCETN NDQPGNKAEK FDHMELDEGN
     YGHEISNSEK LEVMVDPVRA MLLDMIPSLG IKHVKTTNSV VQNEKPHMDN DADIRVVEDE
     KLDADFIPQP QKKKKVSYKD VAGELLKD
//
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