ID A0A1U8N2I0_GOSHI Unreviewed; 493 AA.
AC A0A1U8N2I0;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Aldehyde dehydrogenase {ECO:0000256|PIRNR:PIRNR036492};
GN Name=LOC107943995 {ECO:0000313|RefSeq:XP_016733297.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016733297.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016733297.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016733297.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|PIRNR:PIRNR036492,
CC ECO:0000256|RuleBase:RU003345}.
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DR RefSeq; XP_016733297.1; XM_016877808.1.
DR AlphaFoldDB; A0A1U8N2I0; -.
DR STRING; 3635.A0A1U8N2I0; -.
DR PaxDb; 3635-A0A1U8N2I0; -.
DR GeneID; 107943995; -.
DR KEGG; ghi:107943995; -.
DR OMA; RRITWAA; -.
DR OrthoDB; 1205055at2759; -.
DR Proteomes; UP000189702; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; IBA:GO_Central.
DR GO; GO:0006081; P:cellular aldehyde metabolic process; IBA:GO_Central.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR012394; Aldehyde_DH_NAD(P).
DR PANTHER; PTHR43570; ALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR43570:SF16; ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q; 1.
DR Pfam; PF00171; Aldedh; 1.
DR PIRSF; PIRSF036492; ALDH; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000256|PIRNR:PIRNR036492,
KW ECO:0000256|RuleBase:RU003345};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 469..492
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 14..448
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT ACT_SITE 224
FT /evidence="ECO:0000256|PIRSR:PIRSR036492-1,
FT ECO:0000256|PROSITE-ProRule:PRU10007"
FT ACT_SITE 259
FT /evidence="ECO:0000256|PIRSR:PIRSR036492-1"
SQ SEQUENCE 493 AA; 54205 MW; B46BB48B3DAE8682 CRC64;
MLMENKAENK AVFDAESAKE VVKELRDSFV TGKTKSHRWR VTQLKAMLKM LDENEPQIVA
ALRDDLSKPE FESSLYEIQM LKNSCRLALK EMNHWMMPEK AKTSLTTFPS SAEIVSEPLG
VVLVISAWNY PFLLSLDPVV GAISAGNAIV LKPSEMAPAS SSLIAKLVAD YLDSSCIKVV
EGAVPETSAL LEQKWDKILY TGNGRVARIV MAAAAKHLTP VVLELGGKSP VIVDSNINLK
VATRRIIAGK WGCNNGQACI SPDYIITTKD YATKLVDSFK CELERFYGKD PLESKDLSRI
VNSNHFDRLS KLMDEEKVSS KIVHGGQRNE KNLQIAPTIF LDVPVNSLIM KEEIFGPLLP
IITVDKVEQS FDLIHSSGGK PLAAYLFTNN KKLKRKFVET VSAGGLVVND TAVHLAIHSL
PFGGVGESGM GSYHGKFSFD AFSHKKAVLY RGFAGDAFLR YPPYTPGKLT LLQALLSGSI
VGIIRALLGW FWA
//
