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Database: UniProt/TrEMBL
Entry: A0A1W2WKI5_CIOIN
LinkDB: A0A1W2WKI5_CIOIN
Original site: A0A1W2WKI5_CIOIN 
ID   A0A1W2WKI5_CIOIN        Unreviewed;       854 AA.
AC   A0A1W2WKI5;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   20-DEC-2017, entry version 6.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   Name=zf(parp)-2 {ECO:0000313|RefSeq:XP_002129234.1};
OS   Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Enterogona;
OC   Phlebobranchia; Cionidae; Ciona.
OX   NCBI_TaxID=7719 {ECO:0000313|Proteomes:UP000192222, ECO:0000313|RefSeq:XP_002129234.1};
RN   [1] {ECO:0000313|RefSeq:XP_002129234.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (JUN-2017) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000256|RuleBase:RU000617}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
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DR   RefSeq; XP_002129234.1; XM_002129198.1.
DR   GeneID; 100170070; -.
DR   KEGG; cin:100170070; -.
DR   CTD; 100170070; -.
DR   KO; K10776; -.
DR   Proteomes; UP000192222; Genome assembly.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.3260.10; -; 1.
DR   Gene3D; 3.30.1740.10; -; 1.
DR   Gene3D; 3.40.50.10190; -; 1.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR031916; LIG3_BRCT.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR001510; Znf_PARP.
DR   InterPro; IPR036957; Znf_PARP_sf.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   Pfam; PF16759; LIG3_BRCT; 1.
DR   Pfam; PF00645; zf-PARP; 1.
DR   SMART; SM01336; zf-PARP; 1.
DR   SUPFAM; SSF117018; SSF117018; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS00333; DNA_LIGASE_A2; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
DR   PROSITE; PS50064; PARP_ZN_FINGER_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000192222};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617,
KW   ECO:0000313|RefSeq:XP_002129234.1};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617}.
FT   DOMAIN        7     98       PARP-type. {ECO:0000259|PROSITE:PS50064}.
FT   DOMAIN      474    608       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
FT   COILED      274    301       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   854 AA;  96567 MW;  6E11FCE6BA49DAC7 CRC64;
     MSDSTRFTCD YGKRKSNCKK CKKPIEKGSP RIAKCVPNYF NDGDGEMKQY HHIPCMFETF
     VKARATTKKI EDVSDLDGFA DMKDEEKDEI KKLVATLCAN QAAKKTPKKA TPKKRKSSDP
     VPSPAAKVST PQKKIKTDNS PSTSCAPAPR VGGNSKDNQF REFRRLCGMI AEEASYNEKT
     NIAKRFFEKG SSGDGFTGDL FTIVKLLMPG AVKRTYNLQS KQLVKLFSRI FVEDVDDMME
     DLEQGDVSET VYKFFESNTS CPPTKKSTLT IHDVDDFLEN LSKLTREEDQ LELLKKLAKR
     STGNDLRTVI RLIKCDLKIT AGPKHILDAL DSNAHEAFKA SRDLKDVLDR IEENKKSGSK
     KLEVRASLMT PVSPMLAEAC KSVEQAMKKC PNGMYSEIKY DGERVQLHMK GKDFQFYSRS
     LKPVSDHKIM HFEKYIPDAF PDGHSMILDS EVLLVDVKTG NPLPFGTLGI HKKSKFQDAN
     VCLFIFDILQ FNGENLMGKS MKERRTILET SMKVIPNRVM LSELKFVNKP DDLKHMIVRV
     IKEGLEGLVL KDIKGVYEPG KRHWLKVKKD YLMQGQMADT ADLVVLGAYY GTGSKGGMMS
     VFLMGVYDEK RERWCTVTKV GNGHDDETLE KINKQLKVEK ISKDMKRVPK WLNLNKNHVP
     DLVVADPKNA PVWEITGTEF TQSESHTAEG ISIRFPRVTK IRRDKNWKTA TSLERLKALY
     LKSKEESDIS HLLGVSSTPV VKDEKSTSKS TQKVSVFQQV KENNEEKLLK MAESEFLNDI
     FLGVKIFIPT DVEKRKKMER HILAFNGDVL GNDQFKEATH IVQCDSVKVA DIPISASLVT
     ASHVWECIKN KVSL
//
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