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Database: UniProt/TrEMBL
Entry: A0A1W6XAV8_9RHIZ
LinkDB: A0A1W6XAV8_9RHIZ
Original site: A0A1W6XAV8_9RHIZ 
ID   A0A1W6XAV8_9RHIZ        Unreviewed;       153 AA.
AC   A0A1W6XAV8;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   22-NOV-2017, entry version 5.
DE   RecName: Full=Phosphoribosyl-AMP cyclohydrolase {ECO:0000256|HAMAP-Rule:MF_01021, ECO:0000256|SAAS:SAAS00103129};
DE            Short=PRA-CH {ECO:0000256|HAMAP-Rule:MF_01021};
DE            EC=3.5.4.19 {ECO:0000256|HAMAP-Rule:MF_01021, ECO:0000256|SAAS:SAAS00391815};
GN   Name=hisI {ECO:0000256|HAMAP-Rule:MF_01021};
GN   ORFNames=A9K65_023355 {ECO:0000313|EMBL:ARP65954.1};
OS   Mesorhizobium sp. WSM1497.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Phyllobacteriaceae; Mesorhizobium.
OX   NCBI_TaxID=278153 {ECO:0000313|EMBL:ARP65954.1, ECO:0000313|Proteomes:UP000093884};
RN   [1] {ECO:0000313|EMBL:ARP65954.1, ECO:0000313|Proteomes:UP000093884}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WSM1497 {ECO:0000313|EMBL:ARP65954.1,
RC   ECO:0000313|Proteomes:UP000093884};
RA   Brewer R., Haskett T.L., Ramsay J.P., O'Hara G.W., Terpolilli J.;
RT   "Complete genome sequence of Mesorhizobium sp. WSM1497.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the hydrolysis of the adenine ring of
CC       phosphoribosyl-AMP. {ECO:0000256|HAMAP-Rule:MF_01021,
CC       ECO:0000256|SAAS:SAAS00391850}.
CC   -!- CATALYTIC ACTIVITY: 1-(5-phospho-beta-D-ribosyl)-AMP + H(2)O = 1-
CC       (5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-
CC       ribosylamino)methylideneamino)imidazole-4-carboxamide.
CC       {ECO:0000256|HAMAP-Rule:MF_01021, ECO:0000256|SAAS:SAAS00391825}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-
CC       histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.
CC       {ECO:0000256|HAMAP-Rule:MF_01021, ECO:0000256|SAAS:SAAS00391810}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_01021,
CC       ECO:0000256|SAAS:SAAS00391880}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01021,
CC       ECO:0000256|SAAS:SAAS00006977}.
CC   -!- SIMILARITY: Belongs to the PRA-CH family. {ECO:0000256|HAMAP-
CC       Rule:MF_01021, ECO:0000256|SAAS:SAAS00578260}.
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DR   EMBL; CP021070; ARP65954.1; -; Genomic_DNA.
DR   RefSeq; WP_013531983.1; NZ_CP021070.1.
DR   KEGG; mesw:A9K65_023355; -.
DR   KO; K01496; -.
DR   UniPathway; UPA00031; UER00008.
DR   Proteomes; UP000093884; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004635; F:phosphoribosyl-AMP cyclohydrolase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01021; HisI; 1.
DR   InterPro; IPR026660; PRA-CH.
DR   InterPro; IPR002496; PRib_AMP_CycHydrolase_dom.
DR   Pfam; PF01502; PRA-CH; 1.
DR   ProDom; PD002610; PRA_CycHdrlase; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|HAMAP-Rule:MF_01021,
KW   ECO:0000256|SAAS:SAAS00103205};
KW   Complete proteome {ECO:0000313|Proteomes:UP000093884};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01021,
KW   ECO:0000256|SAAS:SAAS00006957};
KW   Histidine biosynthesis {ECO:0000256|HAMAP-Rule:MF_01021,
KW   ECO:0000256|SAAS:SAAS00103201};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_01021,
KW   ECO:0000256|SAAS:SAAS00469262, ECO:0000313|EMBL:ARP65954.1};
KW   Magnesium {ECO:0000256|HAMAP-Rule:MF_01021,
KW   ECO:0000256|SAAS:SAAS00006960};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_01021,
KW   ECO:0000256|SAAS:SAAS00006980};
KW   Zinc {ECO:0000256|HAMAP-Rule:MF_01021, ECO:0000256|SAAS:SAAS00006961}.
FT   DOMAIN       46    121       PRA-CH. {ECO:0000259|Pfam:PF01502}.
FT   METAL        93     93       Magnesium. {ECO:0000256|HAMAP-Rule:
FT                                MF_01021}.
FT   METAL        94     94       Zinc; shared with dimeric partner.
FT                                {ECO:0000256|HAMAP-Rule:MF_01021}.
FT   METAL        95     95       Magnesium. {ECO:0000256|HAMAP-Rule:
FT                                MF_01021}.
FT   METAL        97     97       Magnesium. {ECO:0000256|HAMAP-Rule:
FT                                MF_01021}.
FT   METAL       112    112       Zinc; shared with dimeric partner.
FT                                {ECO:0000256|HAMAP-Rule:MF_01021}.
FT   METAL       119    119       Zinc; shared with dimeric partner.
FT                                {ECO:0000256|HAMAP-Rule:MF_01021}.
SQ   SEQUENCE   153 AA;  16644 MW;  4270F2EAD1FFDCBD CRC64;
     MSALEFPKAP SDKKALEEGA VFSPRFDAAG LVTVVVTDAA DGMLLMVAHM NAQALALTLE
     TGIAHYWSRS RSALWKKGET SGNFQHVVEM LTDCDQDAIW LRVKVLGHDA TCHTGRRSCF
     YRTVGLVDGK GTLAIDGSKP LFDAENTYRK PTA
//
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