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Database: UniProt/TrEMBL
Entry: A0AE35_STRAM
LinkDB: A0AE35_STRAM
Original site: A0AE35_STRAM 
ID   A0AE35_STRAM            Unreviewed;       739 AA.
AC   A0AE35;
DT   28-NOV-2006, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2006, sequence version 1.
DT   22-NOV-2017, entry version 56.
DE   SubName: Full=Isocitrate dehydrogenase [NADP] {ECO:0000313|EMBL:AKZ59581.1};
DE            EC=1.1.1.42 {ECO:0000313|EMBL:AKZ59581.1};
DE   SubName: Full=Putative isocitrate dehydrogenase {ECO:0000313|EMBL:CAJ88743.1};
GN   Name=icd {ECO:0000313|EMBL:AKZ59581.1};
GN   ORFNames=SAM23877_6536 {ECO:0000313|EMBL:AKZ59581.1}, SAMR1034
GN   {ECO:0000313|EMBL:CAJ88743.1};
OS   Streptomyces ambofaciens ATCC 23877.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=278992 {ECO:0000313|EMBL:CAJ88743.1};
RN   [1] {ECO:0000313|EMBL:CAJ88743.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 23877 {ECO:0000313|EMBL:CAJ88743.1};
RA   Barona-Gomez F., Lautru S., Francou F.X., Leblond P., Pernodet J.L.,
RA   Challis G.L.;
RT   "Multiple biosynthetic and uptake systems mediate siderophore-
RT   dependent iron acquisition in Streptomyces coelicolor A3(2) and
RT   Streptomyces ambofaciens ATCC 23877.";
RL   Microbiology (Mosc.) 152:3355-3366(2006).
RN   [2] {ECO:0000313|EMBL:CAJ88743.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 23877 {ECO:0000313|EMBL:CAJ88743.1};
RX   PubMed=16956972; DOI=10.1093/molbev/msl108;
RA   Choulet F., Aigle B., Gallois A., Mangenot S., Gerbaud C., Truong C.,
RA   Francou F.X., Fourrier C., Guerineau M., Decaris B., Barbe V.,
RA   Pernodet J.L., Leblond P.;
RT   "Evolution of the terminal regions of the Streptomyces linear
RT   chromosome.";
RL   Mol. Biol. Evol. 23:2361-2369(2006).
RN   [3] {ECO:0000313|EMBL:AKZ59581.1, ECO:0000313|Proteomes:UP000061018}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23877 {ECO:0000313|EMBL:AKZ59581.1,
RC   ECO:0000313|Proteomes:UP000061018};
RA   Thibessard A., Haas D., Gerbaud C., Aigle B., Lautru S.,
RA   Pernodet J.-L., Leblond P.;
RT   "Complete genome sequence of Streptomyces ambofaciens ATCC 23877, the
RT   spiramycin producer.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP012382; AKZ59581.1; -; Genomic_DNA.
DR   EMBL; AM238664; CAJ88743.1; -; Genomic_DNA.
DR   RefSeq; WP_053140208.1; NZ_CP012382.1.
DR   EnsemblBacteria; AKZ59581; AKZ59581; SAM23877_6536.
DR   KEGG; samb:SAM23877_6536; -.
DR   KO; K00031; -.
DR   Proteomes; UP000061018; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   PANTHER; PTHR36999; PTHR36999; 1.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000061018};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Oxidoreductase {ECO:0000313|EMBL:AKZ59581.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000061018}.
FT   REGION      132    139       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       348    348       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       546    546       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       550    550       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     145    145       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     545    545       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        255    255       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        418    418       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   739 AA;  79690 MW;  4E2EBDEF2586B171 CRC64;
     MTDSTIIYTH TDEAPALATY SFLPVIRAYA SQAGVPVETR DISLAGRIIA LFPEYLTEDQ
     RIPDALAELG ELAKTPAANI IKLPNISASI PQLKAAIAEL QGQGYALPAY PDDPKTDEER
     DIRARYDKVK GSAVNPVLRE GNSDRRAPAS VKNYAKNHPH RMGAWTAESK TDVATMGEND
     FRSTEKSVVI AEDGALRIEL VGDDGTTTVL RESVPVKKDE VVDASVLRVA ALREFLTAQV
     ARAKAEGILY SVHLKATMMK VSDPIIFGHV VRAFFPKTFA QYGETLAKAG LTPNDGLGGI
     YKGLESLPEG AEIKASFDAE LAEGPELAMV DSDKGISNLH VPSDVIIDAS MPAMIRTSGH
     MWGPDGQEHD ALAVIPDSSY AGVYQAVIDD CRANGAYDPS TMGSVPNVGL MAQKAEEYGS
     HDKTFEIPTT GTVRLVDADG NAVLEQAVSA GDIFRACQTK DAPIRDWVKL AVTRARATGD
     PAVFWLDEGR AHDANLIAKV KAYLPEHDTE GLDIRILSPV EATKLSVERI RRGENTISVT
     GNVLRDYLTD LFPILELGTS AKMLSVVPLM AGGGLFETGA GGSAPKHVQQ LVKENYLRWD
     SLGEFFALVP SLEQYAEVTG NTRAKVLADA LDRATATFLN EDKSPTRRVG GIDNRGSHFF
     LSLYWAQELA RQTDDADLAK AFAPLAETLS ANEQKIVEEL NAVQGEPAEI GGYYQPDPAK
     AAEIMRPSAT WNEALASLA
//
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