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Database: UniProt/TrEMBL
Entry: A0JTW6_ARTS2
LinkDB: A0JTW6_ARTS2
Original site: A0JTW6_ARTS2 
ID   A0JTW6_ARTS2            Unreviewed;       740 AA.
AC   A0JTW6;
DT   12-DEC-2006, integrated into UniProtKB/TrEMBL.
DT   12-DEC-2006, sequence version 1.
DT   22-NOV-2017, entry version 76.
DE   SubName: Full=Isocitrate dehydrogenase, NADP-dependent {ECO:0000313|EMBL:ABK02486.1};
DE            EC=1.1.1.42 {ECO:0000313|EMBL:ABK02486.1};
GN   OrderedLocusNames=Arth_1092 {ECO:0000313|EMBL:ABK02486.1};
OS   Arthrobacter sp. (strain FB24).
OC   Bacteria; Actinobacteria; Micrococcales; Micrococcaceae; Arthrobacter.
OX   NCBI_TaxID=290399 {ECO:0000313|EMBL:ABK02486.1, ECO:0000313|Proteomes:UP000000754};
RN   [1] {ECO:0000313|EMBL:ABK02486.1, ECO:0000313|Proteomes:UP000000754}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FB24 {ECO:0000313|EMBL:ABK02486.1,
RC   ECO:0000313|Proteomes:UP000000754};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Chertkov O., Thompson S., Brettin T., Bruce D., Han C.,
RA   Tapia R., Gilna P., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Mikhailova N., Beasley F., Chen W., Jerke K.,
RA   Nakatsu C.H., Richardson P.;
RT   "Complete sequence of chromosome 1 of Arthrobacter sp. FB24.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP000454; ABK02486.1; -; Genomic_DNA.
DR   RefSeq; WP_011690953.1; NC_008541.1.
DR   ProteinModelPortal; A0JTW6; -.
DR   STRING; 290399.Arth_1092; -.
DR   EnsemblBacteria; ABK02486; ABK02486; Arth_1092.
DR   KEGG; art:Arth_1092; -.
DR   eggNOG; ENOG4105E9K; Bacteria.
DR   eggNOG; COG2838; LUCA.
DR   HOGENOM; HOG000240860; -.
DR   KO; K00031; -.
DR   OMA; RDSGKMW; -.
DR   OrthoDB; POG091H0B3N; -.
DR   Proteomes; UP000000754; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   PANTHER; PTHR36999; PTHR36999; 1.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000754};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Oxidoreductase {ECO:0000313|EMBL:ABK02486.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000754}.
FT   REGION      130    137       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       348    348       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       546    546       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       550    550       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     143    143       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     545    545       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        253    253       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        418    418       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   740 AA;  79980 MW;  AD5233D757F2B6D3 CRC64;
     MAKIIYTHTD EAPMLATYSF LPIVEAYAST AGVEVETRDI SLSGRIISVF GDYLTEEQRI
     SDALAELGDL AKKPEANIIK LPNISASIPQ LKAAIAELQS QGYDLPDYPD NPSSDTETDI
     RSRYDKIKGS AVNPVLREGN SDRRAPLSVK NYARQNPHSM GAWSPESKTN VATMGADDFR
     ANEKSVVIES DDTVKIQLVR EDGTVKVLKR GFPVLAGEVV DGTVMRAAAL DEFLAAQVAR
     AKEEGVLFSA HLKATMMKVS DPIIFGHVVK AYFTELFDTY GEQLAAAGLS PNNGLASILG
     GLEELPEDVR EGVQAAIKKG LAEGPALAMV DSDKGITNLH VPSDVIVDAS MPAMIRSSGH
     MWGPDGKEAD TLAVLPDSSY ASIYQVVIDD CRAHGAFDPT TMGTVPNVGL MAQAAEEYGS
     HDKTFEIQSA GTVQLVDSKG TVLIEHQVAP GDIWRACQAK DVPIRDWVKL AVTRARASEM
     PAVFWLDETR AHDANLIAKV KEYLKDYDTE GLQIEIMSPE KATAFTLERI RKGEDTISVT
     GNVLRDYLTD LFPILELGTS AKMLSVVPLI NGGGLFETGA GGSAPKHVQQ LLKENHLRWD
     SLGEFLALAV SFEHLATTTG NKRAQVLADT LDRATGTFLL ENKSPRRSVG ELDNRGSHFY
     LAKFWAQELA KQTDDAELAA DFAAVSEALT SNEDTIIAEL LAVQGSPVDI GGYYHPDVAK
     VASVMRPSAK FTEVLSGLTK
//
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