ID A1CK95_ASPCL Unreviewed; 632 AA.
AC A1CK95;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 24-JAN-2024, entry version 70.
DE SubName: Full=Phospholipid:diacylglycerol acyltransferase, putative {ECO:0000313|EMBL:EAW09569.1};
GN ORFNames=ACLA_037790 {ECO:0000313|EMBL:EAW09569.1};
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612 {ECO:0000313|EMBL:EAW09569.1, ECO:0000313|Proteomes:UP000006701};
RN [1] {ECO:0000313|EMBL:EAW09569.1, ECO:0000313|Proteomes:UP000006701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1
RC {ECO:0000313|Proteomes:UP000006701};
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
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DR EMBL; DS027056; EAW09569.1; -; Genomic_DNA.
DR RefSeq; XP_001270995.1; XM_001270994.1.
DR AlphaFoldDB; A1CK95; -.
DR STRING; 344612.A1CK95; -.
DR EnsemblFungi; EAW09569; EAW09569; ACLA_037790.
DR GeneID; 4703612; -.
DR KEGG; act:ACLA_037790; -.
DR VEuPathDB; FungiDB:ACLA_037790; -.
DR eggNOG; KOG2369; Eukaryota.
DR HOGENOM; CLU_016065_1_0_1; -.
DR OMA; SMGSQVI; -.
DR OrthoDB; 589269at2759; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0032541; C:cortical endoplasmic reticulum; IEA:EnsemblFungi.
DR GO; GO:0005811; C:lipid droplet; IEA:EnsemblFungi.
DR GO; GO:0005637; C:nuclear inner membrane; IEA:EnsemblFungi.
DR GO; GO:0097038; C:perinuclear endoplasmic reticulum; IEA:EnsemblFungi.
DR GO; GO:0008374; F:O-acyltransferase activity; IEA:InterPro.
DR GO; GO:0046027; F:phospholipid:diacylglycerol acyltransferase activity; IEA:EnsemblFungi.
DR GO; GO:0006672; P:ceramide metabolic process; IEA:EnsemblFungi.
DR GO; GO:0140042; P:lipid droplet formation; IEA:EnsemblFungi.
DR GO; GO:0055091; P:phospholipid homeostasis; IEA:EnsemblFungi.
DR GO; GO:0019432; P:triglyceride biosynthetic process; IEA:EnsemblFungi.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR003386; LACT/PDAT_acylTrfase.
DR PANTHER; PTHR11440:SF97; BCDNA.GH02384; 1.
DR PANTHER; PTHR11440; LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED; 1.
DR Pfam; PF02450; LCAT; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000313|EMBL:EAW09569.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006701};
KW Transferase {ECO:0000313|EMBL:EAW09569.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 62..80
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..27
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 632 AA; 71506 MW; F9B1241FDD569FF4 CRC64;
MLRRRQAKDD HVQPQQEQHE QQKDSSRSEE QVSPPVTEKI IVKEKAPSES FVYKPRSKRR
NGLIFALGGI FGIFIALFFA NQQDVISLES LMDLNLDALI DVIPQGIVRD AREFTQHERD
AVTYDPFSIG LQLQAQGIEA KHPIVMVPGV ISTGLESWGT SPSSRQYFRR RLWGSWSMMR
ALVLDKAEWK NHIMLDKETG LDPPGIKLRA AQGFDATDFF ITGYWIWNKI LENLASIGYD
PTNAFTAAYD WRLSYPNLET RDQYFSRLKS YVETAVLVKG EKVTLASHSM GSQVVLYFFK
WVEHPEHGKG GPDWVNRHIA NWINISGCML GAVKGLTAVL SGEMRDTAQL NAFAVYGLEK
FLSKEERAEI FRAMPGISSM LPKGGEAVWG NSTWAPDDQP GQTMTFGNLL HFRESNSTWT
QKNLTTAESL AYLLDQSEEW YRNQVLTSYS HGVAHTAREV EANENDPRTW LNPLETRLPL
APDMKIYCFY GVGKPTERSY FYQEERDPLV NLNVSIDTTV TTPDGVDHGV LMGEGDGTVN
LLSTGYMCAK GWHIKRYNPA GVKIKVFEMP HEPDRFSPRG GPNTGDHVDI LGRASLNELI
LRVAGGQGEY IEETFVSRIK EYADRVKIYD EE
//
