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Database: UniProt/TrEMBL
Entry: A1DG08_NEOFI
LinkDB: A1DG08_NEOFI
Original site: A1DG08_NEOFI 
ID   A1DG08_NEOFI            Unreviewed;       490 AA.
AC   A1DG08;
DT   23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT   23-JAN-2007, sequence version 1.
DT   05-JUL-2017, entry version 66.
DE   RecName: Full=Phosphotransferase {ECO:0000256|RuleBase:RU362007};
DE            EC=2.7.1.- {ECO:0000256|RuleBase:RU362007};
GN   ORFNames=NFIA_082630 {ECO:0000313|EMBL:EAW18315.1};
OS   Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC
OS   A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=331117 {ECO:0000313|EMBL:EAW18315.1, ECO:0000313|Proteomes:UP000006702};
RN   [1] {ECO:0000313|Proteomes:UP000006702}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 /
RC   NRRL 181 / WB 181 {ECO:0000313|Proteomes:UP000006702};
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P.,
RA   Anderson M.J., Crabtree J., Silva J.C., Badger J.H., Albarraq A.,
RA   Angiuoli S., Bussey H., Bowyer P., Cotty P.J., Dyer P.S., Egan A.,
RA   Galens K., Fraser-Liggett C.M., Haas B.J., Inman J.M., Kent R.,
RA   Lemieux S., Malavazi I., Orvis J., Roemer T., Ronning C.M.,
RA   Sundaram J.P., Sutton G., Turner G., Venter J.C., White O.R.,
RA   Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H., Wortman J.R.,
RA   Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- SIMILARITY: Belongs to the hexokinase family.
CC       {ECO:0000256|RuleBase:RU362007, ECO:0000256|SAAS:SAAS00672880}.
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DR   EMBL; DS027696; EAW18315.1; -; Genomic_DNA.
DR   RefSeq; XP_001260212.1; XM_001260211.1.
DR   ProteinModelPortal; A1DG08; -.
DR   STRING; 36630.CADNFIAP00007871; -.
DR   EnsemblFungi; CADNFIAT00008038; CADNFIAP00007871; CADNFIAG00008038.
DR   GeneID; 4586769; -.
DR   KEGG; nfi:NFIA_082630; -.
DR   EuPathDB; FungiDB:NFIA_082630; -.
DR   HOGENOM; HOG000162670; -.
DR   KO; K00844; -.
DR   OMA; ERQFFRA; -.
DR   OrthoDB; EOG092C2JW4; -.
DR   Proteomes; UP000006702; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR   GO; GO:0004396; F:hexokinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001678; P:cellular glucose homeostasis; IEA:InterPro.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-KW.
DR   InterPro; IPR001312; Hexokinase.
DR   InterPro; IPR019807; Hexokinase_BS.
DR   InterPro; IPR022673; Hexokinase_C.
DR   InterPro; IPR022672; Hexokinase_N.
DR   PANTHER; PTHR19443; PTHR19443; 1.
DR   Pfam; PF00349; Hexokinase_1; 1.
DR   Pfam; PF03727; Hexokinase_2; 1.
DR   PROSITE; PS00378; HEXOKINASE_1; 1.
DR   PROSITE; PS51748; HEXOKINASE_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU362007,
KW   ECO:0000256|SAAS:SAAS00672869};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006702};
KW   Glycolysis {ECO:0000256|RuleBase:RU362007,
KW   ECO:0000256|SAAS:SAAS00672870};
KW   Kinase {ECO:0000256|RuleBase:RU362007, ECO:0000256|SAAS:SAAS00672871,
KW   ECO:0000313|EMBL:EAW18315.1};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU362007,
KW   ECO:0000256|SAAS:SAAS00672883};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006702};
KW   Transferase {ECO:0000256|RuleBase:RU362007,
KW   ECO:0000256|SAAS:SAAS00672884}.
FT   DOMAIN       27    221       Hexokinase_1. {ECO:0000259|Pfam:PF00349}.
FT   DOMAIN      227    466       Hexokinase_2. {ECO:0000259|Pfam:PF03727}.
SQ   SEQUENCE   490 AA;  54282 MW;  69B8CF8B4E1F1DB7 CRC64;
     MVGIGPKRPP SRKGSMADVP QNLLQQIKDF EEMFTVDRAK LKQVVDHFVK ELEKGLSVEG
     GNIPMNVTWV MDFPDGDEQG TFLALDMGGT NLRVCEITLT EEKGGFDICQ SKYRMPEELK
     SGTAEELWEY IADCIQQFIE FHHGEEGLTS LPLGFTFSYP ATQEYIDHGV LQRWTKGFDI
     DGVEGQDVVP PLEETLKRKG LPIKVAALIN DTTGTLIASA YTDPEMKIGC IFGTGVNAAY
     MEDVGSVPKL AHMNLPPDMP VAINCEYGAF DNEHVVLPLT KYDHIIDRDS PRPGQQAFEK
     MTAGLYLGEI FRLALIDLLD SRPGLIFQNQ DTSKLRKPYL LDASFLAAIE EDPYENLQET
     QELFERELNI KPTLAELEMI RRLAELIGTR AARLSACGVA AICKKKNIES CHVGADGSVF
     TKYPHFKARG AQALREILDW APNEKDKVTI MAAEDGSGVG AALIAALTLK RVKAGNLAGI
     RNKDEMQKLL
//
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