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Database: UniProt/TrEMBL
Entry: A1R425_PAEAT
LinkDB: A1R425_PAEAT
Original site: A1R425_PAEAT 
ID   A1R425_PAEAT            Unreviewed;       739 AA.
AC   A1R425;
DT   06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   06-FEB-2007, sequence version 1.
DT   22-NOV-2017, entry version 81.
DE   SubName: Full=Isocitrate dehydrogenase, NADP-dependent {ECO:0000313|EMBL:ABM06743.1};
DE            EC=1.1.1.42 {ECO:0000313|EMBL:ABM06743.1};
GN   OrderedLocusNames=AAur_1201 {ECO:0000313|EMBL:ABM06743.1};
OS   Paenarthrobacter aurescens (strain TC1).
OC   Bacteria; Actinobacteria; Micrococcales; Micrococcaceae;
OC   Paenarthrobacter.
OX   NCBI_TaxID=290340 {ECO:0000313|EMBL:ABM06743.1, ECO:0000313|Proteomes:UP000000637};
RN   [1] {ECO:0000313|EMBL:ABM06743.1, ECO:0000313|Proteomes:UP000000637}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TC1 {ECO:0000313|EMBL:ABM06743.1,
RC   ECO:0000313|Proteomes:UP000000637};
RX   PubMed=17194220; DOI=10.1371/journal.pgen.0020214;
RA   Mongodin E.F., Shapir N., Daugherty S.C., DeBoy R.T., Emerson J.B.,
RA   Shvartzbeyn A., Radune D., Vamathevan J., Riggs F., Grinberg V.,
RA   Khouri H., Wackett L.P., Nelson K.E., Sadowsky M.J.;
RT   "Secrets of soil survival revealed by the genome sequence of
RT   Arthrobacter aurescens TC1.";
RL   PLoS Genet. 2:2094-2106(2006).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP000474; ABM06743.1; -; Genomic_DNA.
DR   RefSeq; WP_011773934.1; NC_008711.1.
DR   ProteinModelPortal; A1R425; -.
DR   STRING; 290340.AAur_1201; -.
DR   EnsemblBacteria; ABM06743; ABM06743; AAur_1201.
DR   GeneID; 29623983; -.
DR   KEGG; aau:AAur_1201; -.
DR   eggNOG; ENOG4105E9K; Bacteria.
DR   eggNOG; COG2838; LUCA.
DR   HOGENOM; HOG000240860; -.
DR   KO; K00031; -.
DR   OMA; RDSGKMW; -.
DR   OrthoDB; POG091H0B3N; -.
DR   Proteomes; UP000000637; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   PANTHER; PTHR36999; PTHR36999; 1.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000637};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Oxidoreductase {ECO:0000313|EMBL:ABM06743.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000637}.
FT   REGION      130    137       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       348    348       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       546    546       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       550    550       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     143    143       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     545    545       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        253    253       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        418    418       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   739 AA;  79676 MW;  8E05BF8C4EE49AF4 CRC64;
     MAKIIYTHTD EAPMLATYSF LPIVEAYAST AGVEVETRDI SLAGRIIAVF GDFLTEEQRT
     GNALAELGEL AKQPEANIIK LPNISASVPQ LKAAIAELQA QGYALPDYPD NPSSDTETDI
     RSRYDKIKGS AVNPVLREGN SDRRAPLSVK NYARQNPHSM GAWSADSKTN VATMGENDFR
     SNEKSVVLKA DDSLSIQLVR EDGTTKVLKK DFPVLAGEVV DATVLRADAL DEFLKAQVAR
     AKEEGVLFSA HLKATMMKVS DPIIFGHVVK AYFSELFETY GKQLAAAGIS PNNGLAAILS
     GLEDLPEDVR DGVKAAITKG LEDGPALAMV DSDKGITSLH VPSDIIVDAS MPAMIRSSGH
     MWGPDGKEAD TLAVIPDSSY AGIYQVVLDD CRANGAFDPT TMGTVPNVGL MAQAAEEYGS
     HDKTFEIQAA GTVQLVDSKG NVLTEHQVFP GDIWRACQTK DIPVRDWVKL AVTRARASQT
     PAVFWLDETR AHDANLIAKV NEYLKDHDTE GLEIKILSPV EATAFTLERI RKGEDTISVT
     GNVLRDYLTD LFPILELGTS AKMLSIVPLI NGGGLFETGA GGSAPKHVQQ LVKENHLRWD
     SLGEFLALAV SFEHLATTTG NARAQVLADT LDRATGTFLL ENKSPRRSVG ELDNRGSHFY
     LATYWAQELA KQTEDAELAK DFAAIAEALT SNEEAIVGEL AAVQGTAVDL GGYYRPDAAK
     AAEIMRPSAT FNKVLATLK
//
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