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Database: UniProt/TrEMBL
Entry: A1R958_PAEAT
LinkDB: A1R958_PAEAT
Original site: A1R958_PAEAT 
ID   A1R958_PAEAT            Unreviewed;       456 AA.
AC   A1R958;
DT   06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   06-FEB-2007, sequence version 1.
DT   25-OCT-2017, entry version 76.
DE   SubName: Full=4-aminobutyrate transaminase {ECO:0000313|EMBL:ABM08874.1};
DE            EC=2.6.1.19 {ECO:0000313|EMBL:ABM08874.1};
GN   Name=gabT {ECO:0000313|EMBL:ABM08874.1};
GN   OrderedLocusNames=AAur_3069 {ECO:0000313|EMBL:ABM08874.1};
OS   Paenarthrobacter aurescens (strain TC1).
OC   Bacteria; Actinobacteria; Micrococcales; Micrococcaceae;
OC   Paenarthrobacter.
OX   NCBI_TaxID=290340 {ECO:0000313|EMBL:ABM08874.1, ECO:0000313|Proteomes:UP000000637};
RN   [1] {ECO:0000313|EMBL:ABM08874.1, ECO:0000313|Proteomes:UP000000637}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TC1 {ECO:0000313|EMBL:ABM08874.1,
RC   ECO:0000313|Proteomes:UP000000637};
RX   PubMed=17194220; DOI=10.1371/journal.pgen.0020214;
RA   Mongodin E.F., Shapir N., Daugherty S.C., DeBoy R.T., Emerson J.B.,
RA   Shvartzbeyn A., Radune D., Vamathevan J., Riggs F., Grinberg V.,
RA   Khouri H., Wackett L.P., Nelson K.E., Sadowsky M.J.;
RT   "Secrets of soil survival revealed by the genome sequence of
RT   Arthrobacter aurescens TC1.";
RL   PLoS Genet. 2:2094-2106(2006).
RN   [2] {ECO:0000213|PDB:4ATP, ECO:0000213|PDB:4ATQ}
RP   X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS), AND PYRIDOXAL PHOSPHATE AT
RP   LYS-295.
RX   PubMed=23027742; DOI=10.1107/S1744309112030023;
RA   Bruce H., Nguyen Tuan A., Mangas Sanchez J., Leese C., Hopwood J.,
RA   Hyde R., Hart S., Turkenburg J.P., Grogan G.;
RT   "Structures of a gamma-aminobutyrate (GABA) transaminase from the s-
RT   triazine-degrading organism Arthrobacter aurescens TC1 in complex with
RT   PLP and with its external aldimine PLP-GABA adduct.";
RL   Acta Crystallogr. F Struct. Biol. Commun. 68:1175-1180(2012).
CC   -!- SIMILARITY: Belongs to the class-III pyridoxal-phosphate-dependent
CC       aminotransferase family. {ECO:0000256|RuleBase:RU003560}.
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DR   EMBL; CP000474; ABM08874.1; -; Genomic_DNA.
DR   RefSeq; WP_011775705.1; NC_008711.1.
DR   PDB; 4ATP; X-ray; 2.80 A; A/B/C/D/E/F/G/H/I/J/K/L=1-456.
DR   PDB; 4ATQ; X-ray; 2.75 A; A/B/C/D/E/F/G/H/I/J/K/L=1-456.
DR   PDBsum; 4ATP; -.
DR   PDBsum; 4ATQ; -.
DR   ProteinModelPortal; A1R958; -.
DR   SMR; A1R958; -.
DR   STRING; 290340.AAur_3069; -.
DR   EnsemblBacteria; ABM08874; ABM08874; AAur_3069.
DR   GeneID; 29623794; -.
DR   KEGG; aau:AAur_3069; -.
DR   eggNOG; ENOG4108JPW; Bacteria.
DR   eggNOG; COG0160; LUCA.
DR   HOGENOM; HOG000020206; -.
DR   KO; K07250; -.
DR   OMA; RVGNYLT; -.
DR   OrthoDB; POG091H0APS; -.
DR   Proteomes; UP000000637; Chromosome.
DR   GO; GO:0034386; F:4-aminobutyrate:2-oxoglutarate transaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0009448; P:gamma-aminobutyric acid metabolic process; IEA:InterPro.
DR   CDD; cd00610; OAT_like; 1.
DR   Gene3D; 3.40.640.10; -; 1.
DR   Gene3D; 3.90.1150.10; -; 2.
DR   InterPro; IPR004632; 4NH2But_aminotransferase_bac.
DR   InterPro; IPR005814; Aminotrans_3.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major_sub1.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_sub2.
DR   Pfam; PF00202; Aminotran_3; 1.
DR   PIRSF; PIRSF000521; Transaminase_4ab_Lys_Orn; 2.
DR   SUPFAM; SSF53383; SSF53383; 1.
DR   TIGRFAMs; TIGR00700; GABAtrnsam; 1.
DR   PROSITE; PS00600; AA_TRANSFER_CLASS_3; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0000213|PDB:4ATP, ECO:0000213|PDB:4ATQ};
KW   Aminotransferase {ECO:0000313|EMBL:ABM08874.1};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000637};
KW   Pyridoxal phosphate {ECO:0000256|RuleBase:RU003560};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000637};
KW   Transferase {ECO:0000313|EMBL:ABM08874.1}.
FT   MOD_RES     295    295       N6-(pyridoxal phosphate)lysine.
FT                                {ECO:0000213|PDB:4ATP}.
SQ   SEQUENCE   456 AA;  47557 MW;  7318C673C41B1ECB CRC64;
     MTTTANELSY RIEQKRNING AFPGPKSQAL AERRSAVVAA GVASGVPVYV EDADGGIIRD
     VDGNSFIDLG SGIAVTSVGA SDPAVVAAVQ EAAAHFTHTC FMVTPYEGYV AVAEQLNRLT
     PGDHAKRTVL FNSGAEAVEN AVKVARLATG RDAVVAFDHA YHGRTNLTMA LTAKAMPYKT
     NFGPFAPEVY RMPMSYPFRE ENPEITGAEA AKRAITMIEK QIGGDQVAAI IIEPIQGEGG
     FIVPAEGFLP ALSEWAKEKG IVFIADEVQS GFCRTGEWFA VDHEGVVPDI ITMAKGIAGG
     LPLSAITGRA DLLDAVHPGG LGGTYGGNPV ACAAALAAID TMEQHDLNGR ARHIEELALG
     KLRELAAELS AGGGSVVGDI RGRGAMLAIE LVQPGSKEPN AELTKAVAAA CLKEGVIILT
     CGTYGNVIRL LPPLVISDEL LIDGLEVLAA AIKAHA
//
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