ID A2BZZ5_PROM1 Unreviewed; 178 AA.
AC A2BZZ5;
DT 20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 20-FEB-2007, sequence version 1.
DT 01-MAY-2013, entry version 45.
DE RecName: Full=N5-carboxyaminoimidazole ribonucleotide mutase;
DE Short=N5-CAIR mutase;
DE EC=5.4.99.18;
GN Name=purE; OrderedLocusNames=NATL1_02411;
OS Prochlorococcus marinus (strain NATL1A).
OC Bacteria; Cyanobacteria; Prochlorales; Prochlorococcaceae;
OC Prochlorococcus.
OX NCBI_TaxID=167555;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NATL1A;
RX PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L.,
RA Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J.,
RA Steglich C., Church G.M., Richardson P., Chisholm S.W.;
RT "Patterns and implications of gene gain and loss in the evolution of
RT Prochlorococcus.";
RL PLoS Genet. 3:E231-E231(2007).
CC -!- FUNCTION: Catalyzes the conversion of N5-carboxyaminoimidazole
CC ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole
CC ribonucleotide (CAIR) (By similarity).
CC -!- CATALYTIC ACTIVITY: 5-carboxyamino-1-(5-phospho-D-
CC ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-
CC carboxylate.
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-
CC amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.
CC -!- SIMILARITY: Belongs to the AIR carboxylase family.
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DR EMBL; CP000553; ABM74805.1; -; Genomic_DNA.
DR RefSeq; YP_001014070.1; NC_008819.1.
DR ProteinModelPortal; A2BZZ5; -.
DR SMR; A2BZZ5; 11-159.
DR STRING; 167555.NATL1_02411; -.
DR EnsemblBacteria; ABM74805; ABM74805; NATL1_02411.
DR GeneID; 4779595; -.
DR KEGG; pme:NATL1_02411; -.
DR PATRIC; 23018007; VBIProMar31285_0249.
DR eggNOG; COG0041; -.
DR HOGENOM; HOG000034141; -.
DR KO; K01588; -.
DR OMA; QSDWATM; -.
DR ProtClustDB; CLSK716096; -.
DR BioCyc; PMAR167555:GI3K-286-MONOMER; -.
DR UniPathway; UPA00074; UER00943.
DR GO; GO:0034023; F:5-(carboxyamino)imidazole ribonucleotide mutase activity; IEA:EC.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.7700; -; 1.
DR InterPro; IPR024694; N5-CAIR_mutase_PurE.
DR InterPro; IPR000031; N5-CAIR_Mutase_PurE_dom.
DR Pfam; PF00731; AIRC; 1.
DR PIRSF; PIRSF001338; AIR_carboxylase; 1.
DR SMART; SM01001; AIRC; 1.
DR SUPFAM; SSF52255; AIR_carboxyl; 1.
DR TIGRFAMs; TIGR01162; purE; 1.
PE 3: Inferred from homology;
KW Complete proteome; Isomerase; Lyase; Purine biosynthesis.
FT BINDING 18 18 Substrate (By similarity).
FT BINDING 21 21 Substrate (By similarity).
FT BINDING 48 48 Substrate (By similarity).
SQ SEQUENCE 178 AA; 18820 MW; 40BDBB919CC87D4F CRC64;
MSLTEANTFK QVAVVMGSDS DLKTLKPAVA ILDQFGISNE VRILSAHRTP KEMMDFAQMA
ESNGFGVIIA GAGGAAHLPG MIASLTTLPV IGVPVKSKAL SGIDSMYSIL QMPSGIPVAT
VAIEGGLNAG LLATQILAIN NTELKNKLNA YRCELHDLVV KKDHTLKEIG AITYLEKM
//
