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Database: UniProt/TrEMBL
Entry: A2C517_PROM1
LinkDB: A2C517_PROM1
Original site: A2C517_PROM1 
ID   A2C517_PROM1            Unreviewed;       994 AA.
AC   A2C517;
DT   20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   20-FEB-2007, sequence version 1.
DT   27-SEP-2017, entry version 73.
DE   RecName: Full=Phosphoenolpyruvate carboxylase {ECO:0000256|HAMAP-Rule:MF_00595, ECO:0000256|SAAS:SAAS00635171};
DE            Short=PEPC {ECO:0000256|HAMAP-Rule:MF_00595};
DE            Short=PEPCase {ECO:0000256|HAMAP-Rule:MF_00595};
DE            EC=4.1.1.31 {ECO:0000256|HAMAP-Rule:MF_00595, ECO:0000256|SAAS:SAAS00635171};
GN   Name=ppc {ECO:0000256|HAMAP-Rule:MF_00595,
GN   ECO:0000313|EMBL:ABM76577.1};
GN   OrderedLocusNames=NATL1_20211 {ECO:0000313|EMBL:ABM76577.1};
OS   Prochlorococcus marinus (strain NATL1A).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochloraceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=167555 {ECO:0000313|EMBL:ABM76577.1, ECO:0000313|Proteomes:UP000002592};
RN   [1] {ECO:0000313|Proteomes:UP000002592}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NATL1A {ECO:0000313|Proteomes:UP000002592};
RX   PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA   Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L.,
RA   Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J.,
RA   Steglich C., Church G.M., Richardson P., Chisholm S.W.;
RT   "Patterns and implications of gene gain and loss in the evolution of
RT   Prochlorococcus.";
RL   PLoS Genet. 3:2515-2528(2007).
CC   -!- FUNCTION: Forms oxaloacetate, a four-carbon dicarboxylic acid
CC       source for the tricarboxylic acid cycle. {ECO:0000256|HAMAP-
CC       Rule:MF_00595}.
CC   -!- CATALYTIC ACTIVITY: Phosphate + oxaloacetate = H(2)O +
CC       phosphoenolpyruvate + HCO(3)(-). {ECO:0000256|HAMAP-Rule:MF_00595,
CC       ECO:0000256|SAAS:SAAS00635165}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00595, ECO:0000256|SAAS:SAAS00635164};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|HAMAP-Rule:MF_00595}.
CC   -!- SIMILARITY: Belongs to the PEPCase type 1 family.
CC       {ECO:0000256|HAMAP-Rule:MF_00595, ECO:0000256|SAAS:SAAS00635168}.
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DR   EMBL; CP000553; ABM76577.1; -; Genomic_DNA.
DR   RefSeq; WP_011824529.1; NC_008819.1.
DR   STRING; 167555.NATL1_20211; -.
DR   EnsemblBacteria; ABM76577; ABM76577; NATL1_20211.
DR   KEGG; pme:NATL1_20211; -.
DR   eggNOG; ENOG4105CCA; Bacteria.
DR   eggNOG; COG2352; LUCA.
DR   HOGENOM; HOG000238647; -.
DR   KO; K01595; -.
DR   OMA; PWVFGWT; -.
DR   OrthoDB; POG091H040O; -.
DR   Proteomes; UP000002592; Chromosome.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008964; F:phosphoenolpyruvate carboxylase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015977; P:carbon fixation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006107; P:oxaloacetate metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   HAMAP; MF_00595; PEPcase_type1; 1.
DR   InterPro; IPR021135; PEP_COase.
DR   InterPro; IPR022805; PEP_COase_bac/pln-type.
DR   InterPro; IPR018129; PEP_COase_Lys_AS.
DR   InterPro; IPR033129; PEPCASE_His_AS.
DR   InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR   Pfam; PF00311; PEPcase; 1.
DR   PRINTS; PR00150; PEPCARBXLASE.
DR   SUPFAM; SSF51621; SSF51621; 1.
DR   PROSITE; PS00781; PEPCASE_1; 1.
DR   PROSITE; PS00393; PEPCASE_2; 1.
PE   3: Inferred from homology;
KW   Carbon dioxide fixation {ECO:0000256|HAMAP-Rule:MF_00595,
KW   ECO:0000256|SAAS:SAAS00635173};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002592};
KW   Lyase {ECO:0000256|HAMAP-Rule:MF_00595, ECO:0000256|SAAS:SAAS00635169,
KW   ECO:0000313|EMBL:ABM76577.1};
KW   Magnesium {ECO:0000256|HAMAP-Rule:MF_00595,
KW   ECO:0000256|SAAS:SAAS00635157};
KW   Pyruvate {ECO:0000313|EMBL:ABM76577.1}.
FT   ACT_SITE    178    178       {ECO:0000256|HAMAP-Rule:MF_00595,
FT                                ECO:0000256|PROSITE-ProRule:PRU10111}.
FT   ACT_SITE    634    634       {ECO:0000256|HAMAP-Rule:MF_00595,
FT                                ECO:0000256|PROSITE-ProRule:PRU10112}.
SQ   SEQUENCE   994 AA;  113224 MW;  36C6955936428EE0 CRC64;
     MLKNPSNENI SNHSTVCVED QDPGSLLQQR LELVEDLWKT VLKSECPPDQ TERLLRLKQL
     SDPSKSNQDN SSKAIVQLIT KMDLAEAISA ARAFSLYFQL VNILEQRIEE DSYLESIEKG
     KLDTSNYKID PFAPALASQT APATFTQLFE RLRRLNVPPA QLDGLMREMD IRLVFTAHPT
     EIVRHTVRHK QRRVATLLQQ LQSNSLISES EKEIFRLQLE EEIRLWWRTD ELHQFKPTVL
     DEVDYALHYF QQVLFDAMPQ LRRRLTTALA SSYPDVEIPN EAFCTFGSWV GSDRDGNPSV
     TPEITWRTAC YQRQLMLDRY IASVQDLRDQ LSISMQWSQV SSPLLESLEM DRVRFPEVYE
     ERAARYRLEP YRLKLSYTLE RLRLTQLRNK QLADAGWQFS PDGKPQISTN NSFDEVLHYK
     SVEELKNELE LIRNSLVSTD LTCEPLDTLL NQVHIFGFSL ASLDIRQEST RHSDALDELT
     RYLDLPESYG VMSEESRVQW LMKELRTRRP LIPPSFEWSK STQETISVFH MLHRLQKEFG
     TRICRSYVIS MSHTASDLLE VLLLAKESGL IDPTLGASDL LVVPLFETVE DLQHAPSVME
     SLLQSDVYRE LLPRVGEKKQ PLQELMLGYS DSNKDSGFLS SNWEIHKAQI ALQDLASRQG
     IALRIFHGRG GSVGRGGGPA YQAILAQPSG TLQGRIKITE QGEVLASKYS LPELALYNLE
     TVTTAVIQNS LVTNKLDATP SWNELMTRLA ARSREHYRAL VHDNPDLVQF FQVVTPIEEI
     SKLQISSRPA RRKSGAKDLS SLRAIPWVFG WTQSRFLLPS WFGVGTALAT ELKADPDQME
     MLRMLNQRWP FFRMLISKVE MTLSKVDLDV AHHYVVSLGG SDDRDAFASI FDIISSEYSL
     TKKLILEITG KSKLLSADPA LQLSVNLRNR TIVPLGFLQV ALLKRLRDQN RQPPISEDVS
     IDSTQSSRTY SRSELLRGAL LTINGIAAGM RNTG
//
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