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Database: UniProt/TrEMBL
Entry: A2QJ58_ASPNC
LinkDB: A2QJ58_ASPNC
Original site: A2QJ58_ASPNC 
ID   A2QJ58_ASPNC            Unreviewed;      1080 AA.
AC   A2QJ58;
DT   06-MAR-2007, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2007, sequence version 1.
DT   24-JAN-2024, entry version 92.
DE   RecName: Full=linoleate 8R-lipoxygenase {ECO:0000256|ARBA:ARBA00013239};
DE            EC=1.13.11.60 {ECO:0000256|ARBA:ARBA00013239};
GN   ORFNames=An04g05880 {ECO:0000313|EMBL:CAK38852.1};
OS   Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=425011 {ECO:0000313|EMBL:CAK38852.1, ECO:0000313|Proteomes:UP000006706};
RN   [1] {ECO:0000313|EMBL:CAK38852.1, ECO:0000313|Proteomes:UP000006706}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 513.88 / FGSC A1513 / ATCC MYA-4892
RC   {ECO:0000313|Proteomes:UP000006706};
RX   PubMed=17259976; DOI=10.1038/nbt1282;
RA   Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA   Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA   Bendtsen J.D., Benen J.A., van den Berg M., Breestraat S., Caddick M.X.,
RA   Contreras R., Cornell M., Coutinho P.M., Danchin E.G., Debets A.J.,
RA   Dekker P., van Dijck P.W., van Dijk A., Dijkhuizen L., Driessen A.J.,
RA   d'Enfert C., Geysens S., Goosen C., Groot G.S., de Groot P.W.,
RA   Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.,
RA   van den Hondel C.A., van der Heijden R.T., van der Kaaij R.M., Klis F.M.,
RA   Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA   van der Maarel M.J., Meulenberg R., Menke H., Mortimer M.A., Nielsen J.,
RA   Oliver S.G., Olsthoorn M., Pal K., van Peij N.N., Ram A.F., Rinas U.,
RA   Roubos J.A., Sagt C.M., Schmoll M., Sun J., Ussery D., Varga J.,
RA   Vervecken W., van de Vondervoort P.J., Wedler H., Wosten H.A., Zeng A.P.,
RA   van Ooyen A.J., Visser J., Stam H.;
RT   "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT   niger CBS 513.88.";
RL   Nat. Biotechnol. 25:221-231(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(9Z,12Z)-octadecadienoate + O2 = (8R,9Z,12Z)-8-
CC         hydroperoxyoctadeca-9,12-dienoate; Xref=Rhea:RHEA:25395,
CC         ChEBI:CHEBI:15379, ChEBI:CHEBI:30245, ChEBI:CHEBI:58659;
CC         EC=1.13.11.60; Evidence={ECO:0000256|ARBA:ARBA00000699};
CC   -!- COFACTOR:
CC       Name=heme b; Xref=ChEBI:CHEBI:60344;
CC         Evidence={ECO:0000256|ARBA:ARBA00001970};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
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DR   EMBL; AM270079; CAK38852.1; -; Genomic_DNA.
DR   RefSeq; XP_001401954.1; XM_001401917.1.
DR   AlphaFoldDB; A2QJ58; -.
DR   PeroxiBase; 5298; AnLDS01.
DR   EnsemblFungi; CAK38852; CAK38852; An04g05880.
DR   GeneID; 4990997; -.
DR   KEGG; ang:ANI_1_966184; -.
DR   VEuPathDB; FungiDB:An04g05880; -.
DR   HOGENOM; CLU_002329_1_0_1; -.
DR   OrthoDB; 3322316at2759; -.
DR   Proteomes; UP000006706; Chromosome 6L.
DR   GO; GO:0051213; F:dioxygenase activity; ISA:AspGD.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0052878; F:linoleate 8R-lipoxygenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   GO; GO:0004601; F:peroxidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   CDD; cd20612; CYP_LDS-like_C; 1.
DR   CDD; cd09817; linoleate_diol_synthase_like; 1.
DR   Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR   Gene3D; 1.10.640.10; Haem peroxidase domain superfamily, animal type; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   InterPro; IPR019791; Haem_peroxidase_animal.
DR   InterPro; IPR010255; Haem_peroxidase_sf.
DR   InterPro; IPR037120; Haem_peroxidase_sf_animal.
DR   InterPro; IPR034812; Ppo-like_N.
DR   PANTHER; PTHR11903; PROSTAGLANDIN G/H SYNTHASE; 1.
DR   PANTHER; PTHR11903:SF37; PSI-PRODUCING OXYGENASE A; 1.
DR   Pfam; PF03098; An_peroxidase; 2.
DR   Pfam; PF00067; p450; 1.
DR   SUPFAM; SSF48264; Cytochrome P450; 1.
DR   SUPFAM; SSF48113; Heme-dependent peroxidases; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
DR   PROSITE; PS50292; PEROXIDASE_3; 1.
PE   4: Predicted;
KW   Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Peroxidase {ECO:0000256|ARBA:ARBA00022559};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006706}.
SQ   SEQUENCE   1080 AA;  120354 MW;  92B611103B567B36 CRC64;
     MSGANNHSIV NGIGSTISQV EKAISASLRP LPTATGNGTY ITEPDQTGIV KDLSHVDFTD
     IKALLEVIKD AVTGQPVDDR HYIMERVIQL AAGLPSTSKN GKDLTNAFLK QLWNDLEHPP
     ISYLGRDSSY RKADGSGNNF LWPHIGAAGS HYARSVRPTT VQSPSLPDPS TLFASLLERK
     EYKEHPNKIS SVLFYLASVI IHDLFQTDRS DFTLNKTSSY LDLSPLYGNN QDEQDLVRTF
     KDGKLKPDCF SSKRVLGFPP GVGVLLLMFN RFHNYVVENL ATINEGGRFT KPDESDVDAS
     TKYDNDLFQT GRLVTCGLYI NIILKDYVRT ILNINRTDSL WSLDPRADIQ DSLLGSAPAE
     ATGNQVSAEF NLVYRWHACI SQRDEKWTQD LYKDLFPGKD PNNVSLQEFI RGVAKWEASL
     PEQPPDRPFA GLQRNADGAF DDGDLANMFA DGVEDCAGAF GAGNIPSVFR NIEALGILQA
     RSWNLATLNE FRKFFDLAPY KTFEEINPDP YIAAQLKNLY DEPDLVEMYP GVIVEATKDA
     IVPGSGLCTN FTISRAILSD AVSLVRGDRF YTVDYTPKHL TNWAYNEIQP QDSVDQGQVF
     YKLVLRAFPN HFKGDSVYAH FPLVIPSENK KILEKLSVAQ DYSWGRPSYT PLPQFISSNA
     ACISVLNDQE AFKVTWGSKI EFLMRHNNHP YGRDFMLSGD KPPNAASRRM MGSALYRDKW
     ESEVKRFYED ITIKLLRQHS YQLGGVNQVD IVRDVANYAQ VHFCANVFSL PLKTESNPRG
     IFAESELYEI LALVFASIFY DADVGTSFQL NQTARDVTQQ LGELTMANVD FVNKAGFIAN
     LVSSLHRHDV LSEYGEHMIQ RLLHSNVPPA EIVWTHLLPT AGGMVANQAQ LFSQCLDYYL
     SDEGSIHLPD IKRLAKENTS EADALLLRYF MEGARLRSSV GLPRLVAKPT VVDDGGSKYT
     LKPGQSVLCN LVSASMDPRS FPEPEKVKLD RDMSLYAHFG FGPHQCLGMG ICKLALTTML
     RVVGRLDNLR RAPGSQGQLK KIAGPGGISM YMTADQSSYW PFPSTMKIQW DGDLPSLATN
//
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