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Database: UniProt/TrEMBL
Entry: A3PFA1_PROM0
LinkDB: A3PFA1_PROM0
Original site: A3PFA1_PROM0 
ID   A3PFA1_PROM0            Unreviewed;       668 AA.
AC   A3PFA1;
DT   03-APR-2007, integrated into UniProtKB/TrEMBL.
DT   03-APR-2007, sequence version 1.
DT   11-JUN-2014, entry version 52.
DE   RecName: Full=Transketolase;
DE            EC=2.2.1.1;
GN   Name=tktA; OrderedLocusNames=P9301_18031;
OS   Prochlorococcus marinus (strain MIT 9301).
OC   Bacteria; Cyanobacteria; Prochlorales; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=167546;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MIT 9301;
RX   PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA   Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L.,
RA   Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J.,
RA   Steglich C., Church G.M., Richardson P., Chisholm S.W.;
RT   "Patterns and implications of gene gain and loss in the evolution of
RT   Prochlorococcus.";
RL   PLoS Genet. 3:2515-2528(2007).
CC   -!- FUNCTION: Catalyzes the transfer of a two-carbon ketol group from
CC       a ketose donor to an aldose acceptor, via a covalent intermediate
CC       with the cofactor thiamine pyrophosphate (By similarity).
CC   -!- CATALYTIC ACTIVITY: Sedoheptulose 7-phosphate + D-glyceraldehyde
CC       3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate.
CC   -!- COFACTOR: Binds 1 magnesium ion per subunit. Can also utilize
CC       other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+)
CC       (By similarity).
CC   -!- COFACTOR: Binds 1 thiamine pyrophosphate per subunit (By
CC       similarity).
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the transketolase family.
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DR   EMBL; CP000576; ABO18426.1; -; Genomic_DNA.
DR   RefSeq; YP_001092027.1; NC_009091.1.
DR   ProteinModelPortal; A3PFA1; -.
DR   SMR; A3PFA1; 3-666.
DR   STRING; 167546.P9301_18031; -.
DR   EnsemblBacteria; ABO18426; ABO18426; P9301_18031.
DR   GeneID; 4911552; -.
DR   KEGG; pmg:P9301_18031; -.
DR   PATRIC; 22997117; VBIProMar103344_1727.
DR   eggNOG; COG0021; -.
DR   HOGENOM; HOG000225953; -.
DR   KO; K00615; -.
DR   OMA; MAMAGRW; -.
DR   OrthoDB; EOG6N3CRG; -.
DR   BioCyc; PMAR167546:GH1Y-1854-MONOMER; -.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004802; F:transketolase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.920; -; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/Pyr-ferredox_oxred.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   InterPro; IPR005478; Transketolase_bac-like.
DR   InterPro; IPR020826; Transketolase_BS.
DR   InterPro; IPR005476; Transketolase_C.
DR   InterPro; IPR005474; Transketolase_N.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   Pfam; PF02780; Transketolase_C; 1.
DR   Pfam; PF00456; Transketolase_N; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; SSF52518; 2.
DR   SUPFAM; SSF52922; SSF52922; 1.
DR   TIGRFAMs; TIGR00232; tktlase_bact; 1.
DR   PROSITE; PS00801; TRANSKETOLASE_1; 1.
DR   PROSITE; PS00802; TRANSKETOLASE_2; 1.
PE   3: Inferred from homology;
KW   Calcium; Complete proteome; Magnesium; Metal-binding;
KW   Thiamine pyrophosphate; Transferase.
SQ   SEQUENCE   668 AA;  72921 MW;  9797E426F728ACF6 CRC64;
     MVAASVSLES LCVNSIRMLA VDAVNKSNSG HPGLPMGCAP MGYALWQNIL NHNPNNPKWF
     NRDRFVLSAG HGCMLLYSLL HLTGYKSVSI DDIKEFRQWG SKTPGHPETF ETEGVEVTAG
     PLGAGISNAV GLAIAETHLA AKFNKPDCKI VDHYTYVIMG DGCNQEGIAS EACSLAGHLK
     LGKLIALYDD NQITIDGRTD VSFTEDVLKR YEAYGWHVQH VEDGNHDVKG ITEAIEKAKL
     ITDKPSIIKI STTIGYGSPN KSDTAGIHGA AVGEEEAALT REFLNWEYPP FEIPDEVYAH
     FRKSIDKGGS LEKEWDSKFE EYQSKYPSEG AELNRMLKGQ LPENWDSDLP SYTPEDKGLA
     TRKHSQICLG ALGPNLPELI GGSADLTHSN YTDIKGESGS FQPHSPEKRY LHFGVREHAM
     AAVLNGIAYH NSGLIPYGGT FLVFADYMRG SMRLSALSEL GVIYVLTHDS IGVGEDGPTH
     QPIETIPSLR AMPNMLVFRP GDGNETSGAY KLAIQNRKRP SALCLSRQGM PNQENTSIDK
     VALGGYVVSD CEGTPDLIFI GTGSELNLCI EASKEISSLG KKVRVVSMPC VELFEEQEDS
     YKESVLPSSV KKRVVVEAAH SFGWHKYTGF DGICITMDRF GASAPGGECM KNFGFTVENV
     VNKTKEIL
//
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