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Database: UniProt/TrEMBL
Entry: A4FC99_SACEN
LinkDB: A4FC99_SACEN
Original site: A4FC99_SACEN 
ID   A4FC99_SACEN            Unreviewed;       337 AA.
AC   A4FC99;
DT   17-APR-2007, integrated into UniProtKB/TrEMBL.
DT   17-APR-2007, sequence version 1.
DT   07-JUN-2017, entry version 74.
DE   SubName: Full=Alcohol dehydrogenase, zinc-binding {ECO:0000313|EMBL:CAM01674.1};
DE            EC=1.1.1.1 {ECO:0000313|EMBL:CAM01674.1};
GN   OrderedLocusNames=SACE_2374 {ECO:0000313|EMBL:CAM01674.1};
OS   Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748
OS   / NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Saccharopolyspora.
OX   NCBI_TaxID=405948 {ECO:0000313|EMBL:CAM01674.1, ECO:0000313|Proteomes:UP000006728};
RN   [1] {ECO:0000313|EMBL:CAM01674.1, ECO:0000313|Proteomes:UP000006728}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC   NRRL 2338 {ECO:0000313|Proteomes:UP000006728};
RX   PubMed=17369815; DOI=10.1038/nbt1297;
RA   Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N.,
RA   Dickens S., Haydock S.F., Leadlay P.F.;
RT   "Complete genome sequence of the erythromycin-producing bacterium
RT   Saccharopolyspora erythraea NRRL23338.";
RL   Nat. Biotechnol. 25:447-453(2007).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU361277};
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. {ECO:0000256|RuleBase:RU361277}.
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DR   EMBL; AM420293; CAM01674.1; -; Genomic_DNA.
DR   RefSeq; WP_009951609.1; NZ_ABFV01000184.1.
DR   ProteinModelPortal; A4FC99; -.
DR   STRING; 405948.SeryN2_010100036940; -.
DR   EnsemblBacteria; CAM01674; CAM01674; SACE_2374.
DR   KEGG; sen:SACE_2374; -.
DR   eggNOG; ENOG4105DQ4; Bacteria.
DR   eggNOG; COG1064; LUCA.
DR   HOGENOM; HOG000294685; -.
DR   KO; K13953; -.
DR   OMA; YKGLKMT; -.
DR   OrthoDB; POG091H06JQ; -.
DR   Proteomes; UP000006728; Chromosome.
DR   GO; GO:0004022; F:alcohol dehydrogenase (NAD) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR013149; ADH_C.
DR   InterPro; IPR013154; ADH_N.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR011032; GroES-like.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR020843; PKS_ER.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; SSF50129; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006728};
KW   Metal-binding {ECO:0000256|RuleBase:RU361277};
KW   Oxidoreductase {ECO:0000313|EMBL:CAM01674.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006728};
KW   Zinc {ECO:0000256|RuleBase:RU361277}.
FT   DOMAIN        8    334       PKS_ER. {ECO:0000259|SMART:SM00829}.
SQ   SEQUENCE   337 AA;  35813 MW;  4016EACA69AAAE63 CRC64;
     MKAAVVHDFA KELTLTEVPK PEPGPGEVVV KIETSGLCHT DIHAAHGDWP VKPKLPLIPG
     HEGVGIVESV GAEVTEVAEG DRVAIPWLGV ACGTCDYCTS GWETLCEKQL NTGYLIDGGY
     AEYAKASAKY VAKVPDGVDP LDAAPLTCAG VTTYKAVKLS GARPAATVAV FGIGGLGHLA
     LQYAKIFGAR VIAVDVVDEK LELARELGAD HTVNALTEDP VQAIKDLGGA DAAISVAVAP
     KAFEQAYSSL RRGGKLVFVA LPADNQVQLP IFETVLNGIT IIGSIVGTRG DLDEVFRLHQ
     QGRTRVIRES RRLEEVNTCF EEVEKGQVKA RLVFDLR
//
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