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Database: UniProt/TrEMBL
Entry: A4FM78_SACEN
LinkDB: A4FM78_SACEN
Original site: A4FM78_SACEN 
ID   A4FM78_SACEN            Unreviewed;       269 AA.
AC   A4FM78;
DT   17-APR-2007, integrated into UniProtKB/TrEMBL.
DT   17-APR-2007, sequence version 1.
DT   31-JAN-2018, entry version 62.
DE   SubName: Full=Secreted trypsin-like serine protease {ECO:0000313|EMBL:CAM05153.1};
DE   SubName: Full=Trypsin {ECO:0000313|EMBL:PFG98790.1};
GN   OrderedLocusNames=SACE_5971 {ECO:0000313|EMBL:CAM05153.1};
GN   ORFNames=A8924_6315 {ECO:0000313|EMBL:PFG98790.1};
OS   Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748
OS   / NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Saccharopolyspora.
OX   NCBI_TaxID=405948 {ECO:0000313|EMBL:CAM05153.1, ECO:0000313|Proteomes:UP000006728};
RN   [1] {ECO:0000313|EMBL:CAM05153.1, ECO:0000313|Proteomes:UP000006728}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC   NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC   {ECO:0000313|EMBL:CAM05153.1};
RX   PubMed=17369815; DOI=10.1038/nbt1297;
RA   Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N.,
RA   Dickens S., Haydock S.F., Leadlay P.F.;
RT   "Complete genome sequence of the erythromycin-producing bacterium
RT   Saccharopolyspora erythraea NRRL23338.";
RL   Nat. Biotechnol. 25:447-453(2007).
RN   [2] {ECO:0000313|EMBL:PFG98790.1, ECO:0000313|Proteomes:UP000225825}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG98790.1,
RC   ECO:0000313|Proteomes:UP000225825};
RA   Klenk H.-P.;
RT   "Sequencing the genomes of 1000 actinobacteria strains.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AM420293; CAM05153.1; -; Genomic_DNA.
DR   EMBL; PDBV01000001; PFG98790.1; -; Genomic_DNA.
DR   RefSeq; WP_011874901.1; NZ_PDBV01000001.1.
DR   ProteinModelPortal; A4FM78; -.
DR   STRING; 405948.SeryN2_010100006727; -.
DR   MEROPS; S01.102; -.
DR   EnsemblBacteria; CAM05153; CAM05153; SACE_5971.
DR   KEGG; sen:SACE_5971; -.
DR   eggNOG; ENOG4105NDH; Bacteria.
DR   eggNOG; COG5640; LUCA.
DR   HOGENOM; HOG000251820; -.
DR   OMA; NSWPSQI; -.
DR   OrthoDB; POG091H0OBT; -.
DR   Proteomes; UP000006728; Chromosome.
DR   Proteomes; UP000225825; Unassembled WGS sequence.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   CDD; cd00190; Tryp_SPc; 1.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   InterPro; IPR033116; TRYPSIN_SER.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF50494; SSF50494; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006728,
KW   ECO:0000313|Proteomes:UP000225825};
KW   Hydrolase {ECO:0000256|RuleBase:RU363034};
KW   Protease {ECO:0000256|RuleBase:RU363034, ECO:0000313|EMBL:CAM05153.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006728};
KW   Serine protease {ECO:0000256|RuleBase:RU363034};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     30       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        31    269       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5011934252.
FT   DOMAIN       44    268       Peptidase S1. {ECO:0000259|PROSITE:
FT                                PS50240}.
SQ   SEQUENCE   269 AA;  27640 MW;  C7ABA7B444B414EB CRC64;
     MARMSRRTWP FLGVAGAVAL SSALLSPAAA GPATGPPVLQ APPIVGGQPA SIAEHPWMVY
     LTDAQGNQLC GGALAAPNKV VTAGHCVLGE KPEGVQVVAG RERLDGKDGT VAKVTGIWVH
     PKYQDASSGS DVAVLTLDQR LPQPPLPVAS QQDTALYQPG TPSTVLGWGK TAENGQSSNE
     LRRGELQVLA DEECTKAYKE QYKADSMTCA GVPGGGVDAC QGDSGGPLVA GDRLIGLVSW
     GDGCARPESP GVYTRIAALH DDIQAQLGS
//
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