ID   A4LBC2_CAEEL            Unreviewed;      1604 AA.
AC   A4LBC2;
DT   01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2007, sequence version 1.
DT   27-MAR-2024, entry version 129.
DE   SubName: Full=Histone-lysine N-methyltransferase {ECO:0000313|EMBL:CCD65166.1};
GN   Name=met-1 {ECO:0000313|EMBL:CCD65166.1,
GN   ECO:0000313|WormBase:C43E11.3a};
GN   ORFNames=C43E11.3 {ECO:0000313|WormBase:C43E11.3a}, CELE_C43E11.3
GN   {ECO:0000313|EMBL:CCD65166.1};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD65166.1, ECO:0000313|Proteomes:UP000001940};
RN   [1] {ECO:0000313|EMBL:CCD65166.1, ECO:0000313|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD65166.1,
RC   ECO:0000313|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RA   Sulson J.E., Waterston R.;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; BX284601; CCD65166.1; -; Genomic_DNA.
DR   RefSeq; NP_491340.2; NM_058939.4.
DR   AlphaFoldDB; A4LBC2; -.
DR   SMR; A4LBC2; -.
DR   STRING; 6239.C43E11.3a.1; -.
DR   iPTMnet; A4LBC2; -.
DR   EPD; A4LBC2; -.
DR   PaxDb; 6239-C43E11-3a; -.
DR   PeptideAtlas; A4LBC2; -.
DR   EnsemblMetazoa; C43E11.3a.1; C43E11.3a.1; WBGene00016603.
DR   GeneID; 172026; -.
DR   KEGG; cel:CELE_C43E11.3; -.
DR   UCSC; C43E11.3a; c. elegans.
DR   AGR; WB:WBGene00016603; -.
DR   WormBase; C43E11.3a; CE30503; WBGene00016603; met-1.
DR   eggNOG; KOG4442; Eukaryota.
DR   InParanoid; A4LBC2; -.
DR   OMA; GYHGNNY; -.
DR   OrthoDB; 950362at2759; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00016603; Expressed in embryo and 10 other cell types or tissues.
DR   ExpressionAtlas; A4LBC2; baseline and differential.
DR   GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0046975; F:histone H3K36 methyltransferase activity; IMP:UniProtKB.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IGI:WormBase.
DR   GO; GO:0040027; P:negative regulation of vulval development; IGI:WormBase.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR   CDD; cd00201; WW; 1.
DR   Gene3D; 2.20.70.10; -; 1.
DR   Gene3D; 2.170.270.10; SET domain; 1.
DR   InterPro; IPR006560; AWS_dom.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   InterPro; IPR001202; WW_dom.
DR   InterPro; IPR036020; WW_dom_sf.
DR   PANTHER; PTHR22884:SF413; HISTONE-LYSINE N-METHYLTRANSFERASE CG1716-RELATED; 1.
DR   PANTHER; PTHR22884; SET DOMAIN PROTEINS; 1.
DR   Pfam; PF00856; SET; 1.
DR   Pfam; PF00397; WW; 1.
DR   SMART; SM00570; AWS; 1.
DR   SMART; SM00508; PostSET; 1.
DR   SMART; SM00317; SET; 1.
DR   SMART; SM00456; WW; 1.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   SUPFAM; SSF51045; WW domain; 1.
DR   PROSITE; PS51215; AWS; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50280; SET; 1.
DR   PROSITE; PS50020; WW_DOMAIN_2; 1.
PE   1: Evidence at protein level;
KW   Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Proteomics identification {ECO:0007829|EPD:A4LBC2,
KW   ECO:0007829|PeptideAtlas:A4LBC2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          636..681
FT                   /note="AWS"
FT                   /evidence="ECO:0000259|PROSITE:PS51215"
FT   DOMAIN          683..805
FT                   /note="SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50280"
FT   DOMAIN          812..828
FT                   /note="Post-SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50868"
FT   DOMAIN          1366..1393
FT                   /note="WW"
FT                   /evidence="ECO:0000259|PROSITE:PS50020"
FT   REGION          1..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          103..351
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          365..420
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          453..607
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1053..1094
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1122..1204
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1434..1544
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1319..1361
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        131..149
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        203..224
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        225..247
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        278..305
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        365..414
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        493..607
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1062..1094
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1161..1188
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1434..1542
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1604 AA;  183463 MW;  3F4AAB1CF9217FF3 CRC64;
     MFQRKVVLPK KRTEMVQTRR KTAAAVQDGG AVKENKAKPP APQTPTKRAK RGRPPKIKTD
     ANTLNTPSTS SNLVDDKLLI ESESQDSILT NEADSFLEKE VEEIEDSSDI LPDKINSPEK
     PSVLVKRRSS TRLKVKTDED EKDVPVNIEV AVLEEKSIQI EPTSPAHPED PQPSTSSLPL
     VEPIEDIVEP NEPTSSADPP VSNIKDEDIK EEEPLIKKPA SDESESMDIA NSESGNDSDS
     SEADPRTIPS FSIPLPDTPP PNFAKRGEIH VDVDQKNSKQ SGESQSPWER AREKSASNPL
     SSPTMSRPRI HFLHPAYQSF TNDSVSPLPP PPPEPAPARE KVENGGPTTF KMTFKKAANI
     PILKTSAFEQ PSSPPPSSSV SSSISLSEVN SSTSIASESS PAKRSSNFDL TASNELPPPQ
     MVELPKLSFF NMPPAVRSAE DDSAMTSEEP ILLLRSPNSA TPDDDALFLT TPPPPKMTES
     EIQALKVATE KVNQVIARRE DSEKDVRHRE DRDDYDRRRD DRDRRSRKTD SERNDQRGRQ
     REDDERRARE REREVTKRHD REREEMRLQK QKDEERRKKD EEERIQKEND EKKQKEDEAK
     MEEEKKKIKE EEMKIPEFEL ISESKYLTRN ANKKKTESLT CECHRTGGNC SDNTCVNRAM
     LTECPSSCQV KCKNQRFAKK KYAAVEAFHT GTAKGCGLRA VKDIKKGRFI IEYIGEVVER
     DDYEKRKTKY AADKKHKHHY LCDTGVYTID ATVYGNPSRF VNHSCDPNAI CEKWSVPRTP
     GDVNRVGFFS KRFIKAGEEI TFDYQFVNYG RDAQQCFCGS ASCSGWIGQK PEEFSSDEDD
     DIVTTRHINM DEEEEEKLEG LDHLGNHERN EVIKDMLDDL VIRNKKHARK VITIASAMTD
     YSQRVDVIQE IFSSDTSVTV QKFYAKEGMA TLMAEWLSED DYSLDNLKLV QAILKALHTE
     LFDSCAKNDR LLRDSTSRWV NAKMDEYVDI QVIADSLIAC VEDPVQEYKD VCKVIEKGLV
     ENFTRAKEMA YRLNQYWFNR SVSFKIPKKI RDPVPKDVPV RQEDATTSSQ SHDNSSRTVS
     PNHRHHSSSY SNSCYQEREP SHIRFFNNGN DVHQYRFGGY HGNNYNDNYF SRRPNKDSYR
     DRRRFNGRRS RSRSRSVSPQ NYKRRKLDEH DNNHRQRSPI RDRHTSPGGE KTPSSNNSGE
     RNYKRLDIRG ARIKTIKEDL EAAAAAAAAA AVPSEVQAYP HEHTAVHQSV YQMPGYESYG
     VYDPVNGVYM YPHPGAGYYP PAYPQQPIML TMDTLPPNDR LGELYEKASI EQLAQRDAIV
     RQELELIRIQ IERKTAQKEA IKAACRRANE EEAKRQEALA KTKYVWAIAK SEAGETYYYN
     KITKETQWTA PTPVQGLLEP ACGASPDTTV VIADEITEEE QQAEVLEKPR VVKEEVIEPG
     SQSETQKESP EKVRVVVPKV EVERSPSPKS SRDREKDREK SREKDRERDR DRREGSKHRD
     SYHGHRNGSS SVSERRMREF KHELERSTRS AVRSRLQHQR DASSDKTTWL IKLIYREIFK
     RESAQSGFDY RFSENTDKKV KNYVKSYIDR KLESNDLWKE YSRP
//

ID   A4LBC3_CAEEL            Unreviewed;      1590 AA.
AC   A4LBC3;
DT   01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2007, sequence version 1.
DT   27-MAR-2024, entry version 130.
DE   SubName: Full=Histone-lysine N-methyltransferase {ECO:0000313|EMBL:CCD65167.1};
GN   Name=met-1 {ECO:0000313|EMBL:CCD65167.1,
GN   ECO:0000313|WormBase:C43E11.3b};
GN   ORFNames=C43E11.3 {ECO:0000313|WormBase:C43E11.3b}, CELE_C43E11.3
GN   {ECO:0000313|EMBL:CCD65167.1};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD65167.1, ECO:0000313|Proteomes:UP000001940};
RN   [1] {ECO:0000313|EMBL:CCD65167.1, ECO:0000313|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD65167.1,
RC   ECO:0000313|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RA   Sulson J.E., Waterston R.;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BX284601; CCD65167.1; -; Genomic_DNA.
DR   PIR; B87754; B87754.
DR   RefSeq; NP_871842.2; NM_182042.2.
DR   SMR; A4LBC3; -.
DR   EPD; A4LBC3; -.
DR   EnsemblMetazoa; C43E11.3b.1; C43E11.3b.1; WBGene00016603.
DR   EnsemblMetazoa; C43E11.3b.2; C43E11.3b.2; WBGene00016603.
DR   EnsemblMetazoa; C43E11.3b.3; C43E11.3b.3; WBGene00016603.
DR   GeneID; 172026; -.
DR   UCSC; C43E11.3a; c. elegans.
DR   AGR; WB:WBGene00016603; -.
DR   WormBase; C43E11.3b; CE08681; WBGene00016603; met-1.
DR   GeneTree; ENSGT00970000195987; -.
DR   HOGENOM; CLU_001589_0_0_1; -.
DR   OrthoDB; 950362at2759; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00016603; Expressed in embryo and 10 other cell types or tissues.
DR   ExpressionAtlas; A4LBC3; baseline and differential.
DR   GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0046975; F:histone H3K36 methyltransferase activity; IMP:UniProtKB.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IGI:WormBase.
DR   GO; GO:0040027; P:negative regulation of vulval development; IGI:WormBase.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR   CDD; cd00201; WW; 1.
DR   Gene3D; 2.20.70.10; -; 1.
DR   Gene3D; 2.170.270.10; SET domain; 1.
DR   InterPro; IPR006560; AWS_dom.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   InterPro; IPR001202; WW_dom.
DR   InterPro; IPR036020; WW_dom_sf.
DR   PANTHER; PTHR22884:SF413; HISTONE-LYSINE N-METHYLTRANSFERASE CG1716-RELATED; 1.
DR   PANTHER; PTHR22884; SET DOMAIN PROTEINS; 1.
DR   Pfam; PF00856; SET; 1.
DR   Pfam; PF00397; WW; 1.
DR   SMART; SM00570; AWS; 1.
DR   SMART; SM00508; PostSET; 1.
DR   SMART; SM00317; SET; 1.
DR   SMART; SM00456; WW; 1.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   SUPFAM; SSF51045; WW domain; 1.
DR   PROSITE; PS51215; AWS; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50280; SET; 1.
DR   PROSITE; PS50020; WW_DOMAIN_2; 1.
PE   1: Evidence at protein level;
KW   Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Proteomics identification {ECO:0007829|EPD:A4LBC3,
KW   ECO:0007829|PeptideAtlas:A4LBC3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          622..667
FT                   /note="AWS"
FT                   /evidence="ECO:0000259|PROSITE:PS51215"
FT   DOMAIN          669..791
FT                   /note="SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50280"
FT   DOMAIN          798..814
FT                   /note="Post-SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50868"
FT   DOMAIN          1352..1379
FT                   /note="WW"
FT                   /evidence="ECO:0000259|PROSITE:PS50020"
FT   REGION          1..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          86..337
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          351..406
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          439..593
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1039..1080
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1108..1190
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1420..1530
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1305..1347
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        117..135
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        189..210
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        211..233
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        264..291
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        351..400
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        479..593
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1048..1080
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1147..1174
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1420..1528
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1590 AA;  181721 MW;  084E00974199EB1C CRC64;
     MVQTRRKTAA AVQDGGAVKE NKAKPPAPQT PTKRAKRGRP PKIKTDANTL NTPSTSSNLV
     DDKLLIESES QDSILTNEAD SFLEKEVEEI EDSSDILPDK INSPEKPSVL VKRRSSTRLK
     VKTDEDEKDV PVNIEVAVLE EKSIQIEPTS PAHPEDPQPS TSSLPLVEPI EDIVEPNEPT
     SSADPPVSNI KDEDIKEEEP LIKKPASDES ESMDIANSES GNDSDSSEAD PRTIPSFSIP
     LPDTPPPNFA KRGEIHVDVD QKNSKQSGES QSPWERAREK SASNPLSSPT MSRPRIHFLH
     PAYQSFTNDS VSPLPPPPPE PAPAREKVEN GGPTTFKMTF KKAANIPILK TSAFEQPSSP
     PPSSSVSSSI SLSEVNSSTS IASESSPAKR SSNFDLTASN ELPPPQMVEL PKLSFFNMPP
     AVRSAEDDSA MTSEEPILLL RSPNSATPDD DALFLTTPPP PKMTESEIQA LKVATEKVNQ
     VIARREDSEK DVRHREDRDD YDRRRDDRDR RSRKTDSERN DQRGRQREDD ERRARERERE
     VTKRHDRERE EMRLQKQKDE ERRKKDEEER IQKENDEKKQ KEDEAKMEEE KKKIKEEEMK
     IPEFELISES KYLTRNANKK KTESLTCECH RTGGNCSDNT CVNRAMLTEC PSSCQVKCKN
     QRFAKKKYAA VEAFHTGTAK GCGLRAVKDI KKGRFIIEYI GEVVERDDYE KRKTKYAADK
     KHKHHYLCDT GVYTIDATVY GNPSRFVNHS CDPNAICEKW SVPRTPGDVN RVGFFSKRFI
     KAGEEITFDY QFVNYGRDAQ QCFCGSASCS GWIGQKPEEF SSDEDDDIVT TRHINMDEEE
     EEKLEGLDHL GNHERNEVIK DMLDDLVIRN KKHARKVITI ASAMTDYSQR VDVIQEIFSS
     DTSVTVQKFY AKEGMATLMA EWLSEDDYSL DNLKLVQAIL KALHTELFDS CAKNDRLLRD
     STSRWVNAKM DEYVDIQVIA DSLIACVEDP VQEYKDVCKV IEKGLVENFT RAKEMAYRLN
     QYWFNRSVSF KIPKKIRDPV PKDVPVRQED ATTSSQSHDN SSRTVSPNHR HHSSSYSNSC
     YQEREPSHIR FFNNGNDVHQ YRFGGYHGNN YNDNYFSRRP NKDSYRDRRR FNGRRSRSRS
     RSVSPQNYKR RKLDEHDNNH RQRSPIRDRH TSPGGEKTPS SNNSGERNYK RLDIRGARIK
     TIKEDLEAAA AAAAAAAVPS EVQAYPHEHT AVHQSVYQMP GYESYGVYDP VNGVYMYPHP
     GAGYYPPAYP QQPIMLTMDT LPPNDRLGEL YEKASIEQLA QRDAIVRQEL ELIRIQIERK
     TAQKEAIKAA CRRANEEEAK RQEALAKTKY VWAIAKSEAG ETYYYNKITK ETQWTAPTPV
     QGLLEPACGA SPDTTVVIAD EITEEEQQAE VLEKPRVVKE EVIEPGSQSE TQKESPEKVR
     VVVPKVEVER SPSPKSSRDR EKDREKSREK DRERDRDRRE GSKHRDSYHG HRNGSSSVSE
     RRMREFKHEL ERSTRSAVRS RLQHQRDASS DKTTWLIKLI YREIFKRESA QSGFDYRFSE
     NTDKKVKNYV KSYIDRKLES NDLWKEYSRP
//