LinkDB: A4LBC3_CAEEL A4LBC2_CAEEL
Original site: A4LBC3_CAEEL A4LBC2_CAEEL
ID A4LBC3_CAEEL Unreviewed; 1590 AA. AC A4LBC3; DT 01-MAY-2007, integrated into UniProtKB/TrEMBL. DT 01-MAY-2007, sequence version 1. DT 27-MAR-2024, entry version 130. DE SubName: Full=Histone-lysine N-methyltransferase {ECO:0000313|EMBL:CCD65167.1}; GN Name=met-1 {ECO:0000313|EMBL:CCD65167.1, GN ECO:0000313|WormBase:C43E11.3b}; GN ORFNames=C43E11.3 {ECO:0000313|WormBase:C43E11.3b}, CELE_C43E11.3 GN {ECO:0000313|EMBL:CCD65167.1}; OS Caenorhabditis elegans. OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; OC Caenorhabditis. OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD65167.1, ECO:0000313|Proteomes:UP000001940}; RN [1] {ECO:0000313|EMBL:CCD65167.1, ECO:0000313|Proteomes:UP000001940} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD65167.1, RC ECO:0000313|Proteomes:UP000001940}; RX PubMed=9851916; DOI=10.1126/science.282.5396.2012; RG The C. elegans sequencing consortium; RA Sulson J.E., Waterston R.; RT "Genome sequence of the nematode C. elegans: a platform for investigating RT biology."; RL Science 282:2012-2018(1998). CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BX284601; CCD65167.1; -; Genomic_DNA. DR PIR; B87754; B87754. DR RefSeq; NP_871842.2; NM_182042.2. DR SMR; A4LBC3; -. DR EPD; A4LBC3; -. DR EnsemblMetazoa; C43E11.3b.1; C43E11.3b.1; WBGene00016603. DR EnsemblMetazoa; C43E11.3b.2; C43E11.3b.2; WBGene00016603. DR EnsemblMetazoa; C43E11.3b.3; C43E11.3b.3; WBGene00016603. DR GeneID; 172026; -. DR UCSC; C43E11.3a; c. elegans. DR AGR; WB:WBGene00016603; -. DR WormBase; C43E11.3b; CE08681; WBGene00016603; met-1. DR GeneTree; ENSGT00970000195987; -. DR HOGENOM; CLU_001589_0_0_1; -. DR OrthoDB; 950362at2759; -. DR Proteomes; UP000001940; Chromosome I. DR Bgee; WBGene00016603; Expressed in embryo and 10 other cell types or tissues. DR ExpressionAtlas; A4LBC3; baseline and differential. DR GO; GO:0000785; C:chromatin; IBA:GO_Central. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0046975; F:histone H3K36 methyltransferase activity; IMP:UniProtKB. DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IGI:WormBase. DR GO; GO:0040027; P:negative regulation of vulval development; IGI:WormBase. DR GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central. DR CDD; cd00201; WW; 1. DR Gene3D; 2.20.70.10; -; 1. DR Gene3D; 2.170.270.10; SET domain; 1. DR InterPro; IPR006560; AWS_dom. DR InterPro; IPR003616; Post-SET_dom. DR InterPro; IPR001214; SET_dom. DR InterPro; IPR046341; SET_dom_sf. DR InterPro; IPR001202; WW_dom. DR InterPro; IPR036020; WW_dom_sf. DR PANTHER; PTHR22884:SF413; HISTONE-LYSINE N-METHYLTRANSFERASE CG1716-RELATED; 1. DR PANTHER; PTHR22884; SET DOMAIN PROTEINS; 1. DR Pfam; PF00856; SET; 1. DR Pfam; PF00397; WW; 1. DR SMART; SM00570; AWS; 1. DR SMART; SM00508; PostSET; 1. DR SMART; SM00317; SET; 1. DR SMART; SM00456; WW; 1. DR SUPFAM; SSF82199; SET domain; 1. DR SUPFAM; SSF51045; WW domain; 1. DR PROSITE; PS51215; AWS; 1. DR PROSITE; PS50868; POST_SET; 1. DR PROSITE; PS50280; SET; 1. DR PROSITE; PS50020; WW_DOMAIN_2; 1. PE 1: Evidence at protein level; KW Chromosome {ECO:0000256|ARBA:ARBA00022454}; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Proteomics identification {ECO:0007829|EPD:A4LBC3, KW ECO:0007829|PeptideAtlas:A4LBC3}; KW Reference proteome {ECO:0000313|Proteomes:UP000001940}; KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}. FT DOMAIN 622..667 FT /note="AWS" FT /evidence="ECO:0000259|PROSITE:PS51215" FT DOMAIN 669..791 FT /note="SET" FT /evidence="ECO:0000259|PROSITE:PS50280" FT DOMAIN 798..814 FT /note="Post-SET" FT /evidence="ECO:0000259|PROSITE:PS50868" FT DOMAIN 1352..1379 FT /note="WW" FT /evidence="ECO:0000259|PROSITE:PS50020" FT REGION 1..57 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 86..337 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 351..406 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 439..593 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1039..1080 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1108..1190 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1420..1530 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 1305..1347 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 117..135 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 189..210 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 211..233 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 264..291 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 351..400 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 479..593 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1048..1080 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1147..1174 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1420..1528 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1590 AA; 181721 MW; 084E00974199EB1C CRC64; MVQTRRKTAA AVQDGGAVKE NKAKPPAPQT PTKRAKRGRP PKIKTDANTL NTPSTSSNLV DDKLLIESES QDSILTNEAD SFLEKEVEEI EDSSDILPDK INSPEKPSVL VKRRSSTRLK VKTDEDEKDV PVNIEVAVLE EKSIQIEPTS PAHPEDPQPS TSSLPLVEPI EDIVEPNEPT SSADPPVSNI KDEDIKEEEP LIKKPASDES ESMDIANSES GNDSDSSEAD PRTIPSFSIP LPDTPPPNFA KRGEIHVDVD QKNSKQSGES QSPWERAREK SASNPLSSPT MSRPRIHFLH PAYQSFTNDS VSPLPPPPPE PAPAREKVEN GGPTTFKMTF KKAANIPILK TSAFEQPSSP PPSSSVSSSI SLSEVNSSTS IASESSPAKR SSNFDLTASN ELPPPQMVEL PKLSFFNMPP AVRSAEDDSA MTSEEPILLL RSPNSATPDD DALFLTTPPP PKMTESEIQA LKVATEKVNQ VIARREDSEK DVRHREDRDD YDRRRDDRDR RSRKTDSERN DQRGRQREDD ERRARERERE VTKRHDRERE EMRLQKQKDE ERRKKDEEER IQKENDEKKQ KEDEAKMEEE KKKIKEEEMK IPEFELISES KYLTRNANKK KTESLTCECH RTGGNCSDNT CVNRAMLTEC PSSCQVKCKN QRFAKKKYAA VEAFHTGTAK GCGLRAVKDI KKGRFIIEYI GEVVERDDYE KRKTKYAADK KHKHHYLCDT GVYTIDATVY GNPSRFVNHS CDPNAICEKW SVPRTPGDVN RVGFFSKRFI KAGEEITFDY QFVNYGRDAQ QCFCGSASCS GWIGQKPEEF SSDEDDDIVT TRHINMDEEE EEKLEGLDHL GNHERNEVIK DMLDDLVIRN KKHARKVITI ASAMTDYSQR VDVIQEIFSS DTSVTVQKFY AKEGMATLMA EWLSEDDYSL DNLKLVQAIL KALHTELFDS CAKNDRLLRD STSRWVNAKM DEYVDIQVIA DSLIACVEDP VQEYKDVCKV IEKGLVENFT RAKEMAYRLN QYWFNRSVSF KIPKKIRDPV PKDVPVRQED ATTSSQSHDN SSRTVSPNHR HHSSSYSNSC YQEREPSHIR FFNNGNDVHQ YRFGGYHGNN YNDNYFSRRP NKDSYRDRRR FNGRRSRSRS RSVSPQNYKR RKLDEHDNNH RQRSPIRDRH TSPGGEKTPS SNNSGERNYK RLDIRGARIK TIKEDLEAAA AAAAAAAVPS EVQAYPHEHT AVHQSVYQMP GYESYGVYDP VNGVYMYPHP GAGYYPPAYP QQPIMLTMDT LPPNDRLGEL YEKASIEQLA QRDAIVRQEL ELIRIQIERK TAQKEAIKAA CRRANEEEAK RQEALAKTKY VWAIAKSEAG ETYYYNKITK ETQWTAPTPV QGLLEPACGA SPDTTVVIAD EITEEEQQAE VLEKPRVVKE EVIEPGSQSE TQKESPEKVR VVVPKVEVER SPSPKSSRDR EKDREKSREK DRERDRDRRE GSKHRDSYHG HRNGSSSVSE RRMREFKHEL ERSTRSAVRS RLQHQRDASS DKTTWLIKLI YREIFKRESA QSGFDYRFSE NTDKKVKNYV KSYIDRKLES NDLWKEYSRP //
ID A4LBC2_CAEEL Unreviewed; 1604 AA. AC A4LBC2; DT 01-MAY-2007, integrated into UniProtKB/TrEMBL. DT 01-MAY-2007, sequence version 1. DT 27-MAR-2024, entry version 129. DE SubName: Full=Histone-lysine N-methyltransferase {ECO:0000313|EMBL:CCD65166.1}; GN Name=met-1 {ECO:0000313|EMBL:CCD65166.1, GN ECO:0000313|WormBase:C43E11.3a}; GN ORFNames=C43E11.3 {ECO:0000313|WormBase:C43E11.3a}, CELE_C43E11.3 GN {ECO:0000313|EMBL:CCD65166.1}; OS Caenorhabditis elegans. OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; OC Caenorhabditis. OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD65166.1, ECO:0000313|Proteomes:UP000001940}; RN [1] {ECO:0000313|EMBL:CCD65166.1, ECO:0000313|Proteomes:UP000001940} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD65166.1, RC ECO:0000313|Proteomes:UP000001940}; RX PubMed=9851916; DOI=10.1126/science.282.5396.2012; RG The C. elegans sequencing consortium; RA Sulson J.E., Waterston R.; RT "Genome sequence of the nematode C. elegans: a platform for investigating RT biology."; RL Science 282:2012-2018(1998). CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BX284601; CCD65166.1; -; Genomic_DNA. DR RefSeq; NP_491340.2; NM_058939.4. DR AlphaFoldDB; A4LBC2; -. DR SMR; A4LBC2; -. DR STRING; 6239.C43E11.3a.1; -. DR iPTMnet; A4LBC2; -. DR EPD; A4LBC2; -. DR PaxDb; 6239-C43E11-3a; -. DR PeptideAtlas; A4LBC2; -. DR EnsemblMetazoa; C43E11.3a.1; C43E11.3a.1; WBGene00016603. DR GeneID; 172026; -. DR KEGG; cel:CELE_C43E11.3; -. DR UCSC; C43E11.3a; c. elegans. DR AGR; WB:WBGene00016603; -. DR WormBase; C43E11.3a; CE30503; WBGene00016603; met-1. DR eggNOG; KOG4442; Eukaryota. DR InParanoid; A4LBC2; -. DR OMA; GYHGNNY; -. DR OrthoDB; 950362at2759; -. DR Proteomes; UP000001940; Chromosome I. DR Bgee; WBGene00016603; Expressed in embryo and 10 other cell types or tissues. DR ExpressionAtlas; A4LBC2; baseline and differential. DR GO; GO:0000785; C:chromatin; IBA:GO_Central. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0046975; F:histone H3K36 methyltransferase activity; IMP:UniProtKB. DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IGI:WormBase. DR GO; GO:0040027; P:negative regulation of vulval development; IGI:WormBase. DR GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central. DR CDD; cd00201; WW; 1. DR Gene3D; 2.20.70.10; -; 1. DR Gene3D; 2.170.270.10; SET domain; 1. DR InterPro; IPR006560; AWS_dom. DR InterPro; IPR003616; Post-SET_dom. DR InterPro; IPR001214; SET_dom. DR InterPro; IPR046341; SET_dom_sf. DR InterPro; IPR001202; WW_dom. DR InterPro; IPR036020; WW_dom_sf. DR PANTHER; PTHR22884:SF413; HISTONE-LYSINE N-METHYLTRANSFERASE CG1716-RELATED; 1. DR PANTHER; PTHR22884; SET DOMAIN PROTEINS; 1. DR Pfam; PF00856; SET; 1. DR Pfam; PF00397; WW; 1. DR SMART; SM00570; AWS; 1. DR SMART; SM00508; PostSET; 1. DR SMART; SM00317; SET; 1. DR SMART; SM00456; WW; 1. DR SUPFAM; SSF82199; SET domain; 1. DR SUPFAM; SSF51045; WW domain; 1. DR PROSITE; PS51215; AWS; 1. DR PROSITE; PS50868; POST_SET; 1. DR PROSITE; PS50280; SET; 1. DR PROSITE; PS50020; WW_DOMAIN_2; 1. PE 1: Evidence at protein level; KW Chromosome {ECO:0000256|ARBA:ARBA00022454}; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Proteomics identification {ECO:0007829|EPD:A4LBC2, KW ECO:0007829|PeptideAtlas:A4LBC2}; KW Reference proteome {ECO:0000313|Proteomes:UP000001940}; KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}. FT DOMAIN 636..681 FT /note="AWS" FT /evidence="ECO:0000259|PROSITE:PS51215" FT DOMAIN 683..805 FT /note="SET" FT /evidence="ECO:0000259|PROSITE:PS50280" FT DOMAIN 812..828 FT /note="Post-SET" FT /evidence="ECO:0000259|PROSITE:PS50868" FT DOMAIN 1366..1393 FT /note="WW" FT /evidence="ECO:0000259|PROSITE:PS50020" FT REGION 1..71 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 103..351 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 365..420 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 453..607 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1053..1094 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1122..1204 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1434..1544 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 1319..1361 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 131..149 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 203..224 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 225..247 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 278..305 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 365..414 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 493..607 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1062..1094 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1161..1188 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1434..1542 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1604 AA; 183463 MW; 3F4AAB1CF9217FF3 CRC64; MFQRKVVLPK KRTEMVQTRR KTAAAVQDGG AVKENKAKPP APQTPTKRAK RGRPPKIKTD ANTLNTPSTS SNLVDDKLLI ESESQDSILT NEADSFLEKE VEEIEDSSDI LPDKINSPEK PSVLVKRRSS TRLKVKTDED EKDVPVNIEV AVLEEKSIQI EPTSPAHPED PQPSTSSLPL VEPIEDIVEP NEPTSSADPP VSNIKDEDIK EEEPLIKKPA SDESESMDIA NSESGNDSDS SEADPRTIPS FSIPLPDTPP PNFAKRGEIH VDVDQKNSKQ SGESQSPWER AREKSASNPL SSPTMSRPRI HFLHPAYQSF TNDSVSPLPP PPPEPAPARE KVENGGPTTF KMTFKKAANI PILKTSAFEQ PSSPPPSSSV SSSISLSEVN SSTSIASESS PAKRSSNFDL TASNELPPPQ MVELPKLSFF NMPPAVRSAE DDSAMTSEEP ILLLRSPNSA TPDDDALFLT TPPPPKMTES EIQALKVATE KVNQVIARRE DSEKDVRHRE DRDDYDRRRD DRDRRSRKTD SERNDQRGRQ REDDERRARE REREVTKRHD REREEMRLQK QKDEERRKKD EEERIQKEND EKKQKEDEAK MEEEKKKIKE EEMKIPEFEL ISESKYLTRN ANKKKTESLT CECHRTGGNC SDNTCVNRAM LTECPSSCQV KCKNQRFAKK KYAAVEAFHT GTAKGCGLRA VKDIKKGRFI IEYIGEVVER DDYEKRKTKY AADKKHKHHY LCDTGVYTID ATVYGNPSRF VNHSCDPNAI CEKWSVPRTP GDVNRVGFFS KRFIKAGEEI TFDYQFVNYG RDAQQCFCGS ASCSGWIGQK PEEFSSDEDD DIVTTRHINM DEEEEEKLEG LDHLGNHERN EVIKDMLDDL VIRNKKHARK VITIASAMTD YSQRVDVIQE IFSSDTSVTV QKFYAKEGMA TLMAEWLSED DYSLDNLKLV QAILKALHTE LFDSCAKNDR LLRDSTSRWV NAKMDEYVDI QVIADSLIAC VEDPVQEYKD VCKVIEKGLV ENFTRAKEMA YRLNQYWFNR SVSFKIPKKI RDPVPKDVPV RQEDATTSSQ SHDNSSRTVS PNHRHHSSSY SNSCYQEREP SHIRFFNNGN DVHQYRFGGY HGNNYNDNYF SRRPNKDSYR DRRRFNGRRS RSRSRSVSPQ NYKRRKLDEH DNNHRQRSPI RDRHTSPGGE KTPSSNNSGE RNYKRLDIRG ARIKTIKEDL EAAAAAAAAA AVPSEVQAYP HEHTAVHQSV YQMPGYESYG VYDPVNGVYM YPHPGAGYYP PAYPQQPIML TMDTLPPNDR LGELYEKASI EQLAQRDAIV RQELELIRIQ IERKTAQKEA IKAACRRANE EEAKRQEALA KTKYVWAIAK SEAGETYYYN KITKETQWTA PTPVQGLLEP ACGASPDTTV VIADEITEEE QQAEVLEKPR VVKEEVIEPG SQSETQKESP EKVRVVVPKV EVERSPSPKS SRDREKDREK SREKDRERDR DRREGSKHRD SYHGHRNGSS SVSERRMREF KHELERSTRS AVRSRLQHQR DASSDKTTWL IKLIYREIFK RESAQSGFDY RFSENTDKKV KNYVKSYIDR KLESNDLWKE YSRP //