ID   A4TH32_YERPP            Unreviewed;       532 AA.
AC   A4TH32;
DT   15-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   15-MAY-2007, sequence version 1.
DT   01-MAY-2013, entry version 49.
DE   RecName: Full=Malate synthase;
DE            EC=2.3.3.9;
GN   OrderedLocusNames=YPDSF_0173;
OS   Yersinia pestis (strain Pestoides F).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Yersinia.
OX   NCBI_TaxID=386656;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pestoides F;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Di Bartolo G., Chain P., Malfatti S., Shin M., Vergez L.,
RA   Schmutz J., Larimer F., Land M., Hauser L., Worsham P., Chu M.,
RA   Bearden S., Garcia E., Richardson P.;
RT   "Complete sequence of chromosome of Yersinia pestis Pestoides F.";
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Acetyl-CoA + H(2)O + glyoxylate = (S)-malate +
CC       CoA.
CC   -!- PATHWAY: Carbohydrate metabolism; glyoxylate cycle; (S)-malate
CC       from isocitrate: step 2/2.
CC   -!- SIMILARITY: Belongs to the malate synthase family.
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DR   EMBL; CP000668; ABP38595.1; -; Genomic_DNA.
DR   PIR; AF0453; AF0453.
DR   RefSeq; YP_001161567.1; NC_009381.1.
DR   ProteinModelPortal; A4TH32; -.
DR   STRING; 386656.YPDSF_0173; -.
DR   EnsemblBacteria; ABP38595; ABP38595; YPDSF_0173.
DR   GeneID; 5063757; -.
DR   KEGG; ypp:YPDSF_0173; -.
DR   PATRIC; 18609076; VBIYerPes122972_0463.
DR   eggNOG; COG2225; -.
DR   HOGENOM; HOG000238464; -.
DR   KO; K01638; -.
DR   OMA; GFDGTWV; -.
DR   ProtClustDB; PRK09255; -.
DR   UniPathway; UPA00703; UER00720.
DR   GO; GO:0004474; F:malate synthase activity; IEA:EC.
DR   GO; GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
DR   InterPro; IPR011076; Malate_synth-like.
DR   InterPro; IPR006252; Malate_synthA.
DR   InterPro; IPR001465; Malate_synthase.
DR   PANTHER; PTHR21631:SF1; PTHR21631:SF1; 1.
DR   Pfam; PF01274; Malate_synthase; 1.
DR   PIRSF; PIRSF001363; Malate_synth; 1.
DR   SUPFAM; SSF51645; Malat_synth_like; 1.
DR   TIGRFAMs; TIGR01344; malate_syn_A; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Complete proteome; Glyoxylate bypass; Transferase;
KW   Tricarboxylic acid cycle.
FT   ACT_SITE    165    165       Proton acceptor (By similarity).
FT   ACT_SITE    446    446       Proton donor (By similarity).
SQ   SEQUENCE   532 AA;  60257 MW;  B7D2734DAED5CC98 CRC64;
     MRQQLAGTEL VFTQPFNAAE RQVLPDKAIE FLTELVVKFS ESRNQLLATR ASWQQTIDQG
     ALPDFILETN SIRDGDWKIQ GIPADLRDRR VEITGPVERK MVINALNANV KVFMADFEDS
     LAPSWDKVID GQINLHDAVK GTISYTNESG KVYQLKPNPA VLIARVRGLH LPEKHVKWQD
     EAIPGGLFDF ALYFYHNYQQ LLAKGSGPYF YLPKMQSYQE AAWWSDVFNF TEQRFGLSQG
     TIKATVLIET LPAVFQMDEI LYHLRHHIVG LNCGRWDYIF SYIKTLKNHP DRVLPDRQSV
     TMNKPFLSAY SRLLIKTCHK RGALAMGGMA AFIPDKDAEK NKLVLDKVRA DKELEASNGH
     DGTWVAHPGL ADTVMDVFNK VLGSRPNQLE VSREQDKPIT AAELLEPCSG ERTEAGMRAN
     IRVAVQYIEA WISGNGCVPI YGLMEDAATA EISRTSIWQW IHHQKSLSNG QTVTKELFRS
     MLSEEIQVVK LELGAERFDR GRFEEAARLM ERITTQDELI DFLTLPGYAL LA
//