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Database: UniProt/TrEMBL
Entry: A4VLW0_PSEU5
LinkDB: A4VLW0_PSEU5
Original site: A4VLW0_PSEU5 
ID   A4VLW0_PSEU5            Unreviewed;       742 AA.
AC   A4VLW0;
DT   29-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2007, sequence version 1.
DT   27-SEP-2017, entry version 64.
DE   SubName: Full=Isocitrate dehydrogenase {ECO:0000313|EMBL:ABP79961.1};
GN   Name=idh {ECO:0000313|EMBL:ABP79961.1};
GN   OrderedLocusNames=PST_2302 {ECO:0000313|EMBL:ABP79961.1};
OS   Pseudomonas stutzeri (strain A1501).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=379731 {ECO:0000313|EMBL:ABP79961.1, ECO:0000313|Proteomes:UP000000233};
RN   [1] {ECO:0000313|EMBL:ABP79961.1, ECO:0000313|Proteomes:UP000000233}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A1501 {ECO:0000313|EMBL:ABP79961.1,
RC   ECO:0000313|Proteomes:UP000000233};
RX   PubMed=18495935; DOI=10.1073/pnas.0801093105;
RA   Yan Y., Yang J., Dou Y., Chen M., Ping S., Peng J., Lu W., Zhang W.,
RA   Yao Z., Li H., Liu W., He S., Geng L., Zhang X., Yang F., Yu H.,
RA   Zhan Y., Li D., Lin Z., Wang Y., Elmerich C., Lin M., Jin Q.;
RT   "Nitrogen fixation island and rhizosphere competence traits in the
RT   genome of root-associated Pseudomonas stutzeri A1501.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:7564-7569(2008).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP000304; ABP79961.1; -; Genomic_DNA.
DR   RefSeq; WP_011913427.1; NC_009434.1.
DR   STRING; 379731.PST_2302; -.
DR   EnsemblBacteria; ABP79961; ABP79961; PST_2302.
DR   KEGG; psa:PST_2302; -.
DR   eggNOG; ENOG4105E9K; Bacteria.
DR   eggNOG; COG2838; LUCA.
DR   HOGENOM; HOG000240860; -.
DR   KO; K00031; -.
DR   OMA; RDSGKMW; -.
DR   OrthoDB; POG091H0B3N; -.
DR   Proteomes; UP000000233; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000233};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000233}.
FT   REGION      133    140       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       350    350       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       548    548       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       552    552       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     146    146       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     547    547       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        255    255       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        420    420       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   742 AA;  81729 MW;  5763B0754E842C88 CRC64;
     MSTPSKIIYT FTDEAPALAT YSLLPIVEAF AASADISVET RDISLAGRIL ASFADQLDAD
     KKVEDDLAKL AELTNQPDAN IIKLPNISAS VPQLKAAIAE LQALGYNIPN YPEDPQTDAE
     KDARARYSKV LGSAVNPVLR EGNSDRRAPA AVKAYARKHP HSMGKWSKAS QSHADYMRGG
     DFFSSEQSIT MEKAGDVRIE FVGKDGKVEV KKQLALQEGE VLDGMFMSCK KLRAFFEDTL
     QDCKETGVMW SLHVKATMMK ISHPIVFGHA VSVYYKDVFD KYGDLFKELG VNPNNGISSV
     YDKIKSLPAS QQEEILHDIH EVYSHRPEMA MVDSVKGITN LHIPSDVIVD ASMPAMIRNS
     GQMWGKDGKQ KDTKAVMPES TYARIYQEMI NFCKTNGAFD PVTMGSVPNV GLMAQKAEEY
     GSHDKTFEMH ADGTMRVVLA DGTVLMQHEV EKGDIWRACQ TKDAPIRDWV KLAVTRARQS
     NTPAVFWLDP ERAHDMQLQK KVETYLQEHD LSGLDIRIMG YNEAIRLSME RMIRGKDTIS
     VTGNVLRDYL TDLFPIMELG TSAKMLSIVP LMAGGGMYET GAGGSAPKHV QQLVEENYLR
     WDSLGEFLAL AVSLEETGIK TGNSKAKILG KTLDQATGKL LDNNKSPARK VGQIDNRGSH
     FYLALYWAQA LAAQDEDAEL KAHFTPLAKT LTEQEAAIVA ELAAVQGKPV DIGGYYRSNP
     ELTSKVMRPS ATFNAALAAL NA
//
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