ID A5D1T7_PELTS Unreviewed; 300 AA.
AC A5D1T7;
DT 12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 12-JUN-2007, sequence version 1.
DT 29-MAY-2013, entry version 46.
DE RecName: Full=Homoserine kinase;
DE Short=HK;
DE Short=HSK;
DE EC=2.7.1.39;
GN Name=ThrB; Synonyms=thrB; OrderedLocusNames=PTH_1600;
OS Pelotomaculum thermopropionicum (strain DSM 13744 / JCM 10971 / SI).
OC Bacteria; Firmicutes; Clostridia; Clostridiales; Peptococcaceae;
OC Pelotomaculum.
OX NCBI_TaxID=370438;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 13744 / JCM 10971 / SI;
RX PubMed=18218977; DOI=10.1101/gr.7136508;
RA Kosaka T., Kato S., Shimoyama T., Ishii S., Abe T., Watanabe K.;
RT "The genome of Pelotomaculum thermopropionicum reveals niche-
RT associated evolution in anaerobic microbiota.";
RL Genome Res. 18:442-448(2008).
CC -!- FUNCTION: Catalyzes the ATP-dependent phosphorylation of L-
CC homoserine to L-homoserine phosphate (By similarity).
CC -!- CATALYTIC ACTIVITY: ATP + L-homoserine = ADP + O-phospho-L-
CC homoserine.
CC -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC threonine from L-aspartate: step 4/5.
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the GHMP kinase family. Homoserine kinase
CC subfamily.
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DR EMBL; AP009389; BAF59781.1; -; Genomic_DNA.
DR RefSeq; YP_001212150.1; NC_009454.1.
DR ProteinModelPortal; A5D1T7; -.
DR STRING; 370438.PTH_1600; -.
DR EnsemblBacteria; BAF59781; BAF59781; PTH_1600.
DR GeneID; 5138941; -.
DR KEGG; pth:PTH_1600; -.
DR PATRIC; 22910435; VBIPelThe8413_1809.
DR eggNOG; COG0083; -.
DR HOGENOM; HOG000247199; -.
DR KO; K00872; -.
DR OMA; LHEPYRW; -.
DR ProtClustDB; CLSK853519; -.
DR BioCyc; PTHE370438:GCGQ-1649-MONOMER; -.
DR UniPathway; UPA00050; UER00064.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR GO; GO:0004413; F:homoserine kinase activity; IEA:HAMAP.
DR GO; GO:0009088; P:threonine biosynthetic process; IEA:HAMAP.
DR Gene3D; 3.30.230.10; -; 1.
DR HAMAP; MF_00384; Homoser_kinase; 1; -.
DR InterPro; IPR013750; GHMP_kinase_C_dom.
DR InterPro; IPR006204; GHMP_kinase_N_dom.
DR InterPro; IPR000870; Homoserine_kinase.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR Pfam; PF08544; GHMP_kinases_C; 1.
DR Pfam; PF00288; GHMP_kinases_N; 1.
DR PIRSF; PIRSF000676; Homoser_kin; 1.
DR PRINTS; PR00958; HOMSERKINASE.
DR SUPFAM; SSF54211; Ribosomal_S5_D2-typ_fold; 1.
DR TIGRFAMs; TIGR00191; thrB; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; ATP-binding; Complete proteome; Cytoplasm;
KW Kinase; Nucleotide-binding; Threonine biosynthesis; Transferase.
SQ SEQUENCE 300 AA; 31193 MW; FB5CBBB0CFD7C09A CRC64;
MIRVQVPATS ANLGPGFDCL GMALELYNIV EMIPASRGLV IEVSGESAAD IPRDERNLVF
QAAQRVFGNT GFSPPGLKLR LINQIPAARG LGSSTAAVVG GVVAANLLSG GKLGVKDMIN
LASSIEGHPD NVAPAILGGI VVSVQMDGEV KCLKIQPPQG LKGVVAVPDF PLATRTAREI
LPSQVPFQDA VFNLGRVALL VAALQQGDLS LLGPAMEDRL HQSLRSSLIP GLKKVLAAAK
LAGARGVTLS GAGPAVIAFA DSNFDLIARV MSDTFRQNGV KSRVMVLKPS PVGVRAFEIK
//
