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Database: UniProt/TrEMBL
Entry: A5DI82_PICGU
LinkDB: A5DI82_PICGU
Original site: A5DI82_PICGU 
ID   A5DI82_PICGU            Unreviewed;       937 AA.
AC   A5DI82;
DT   12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2008, sequence version 2.
DT   25-OCT-2017, entry version 67.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   ORFNames=PGUG_02983 {ECO:0000313|EMBL:EDK38885.2};
OS   Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM
OS   1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX   NCBI_TaxID=294746 {ECO:0000313|EMBL:EDK38885.2, ECO:0000313|Proteomes:UP000001997};
RN   [1] {ECO:0000313|EMBL:EDK38885.2, ECO:0000313|Proteomes:UP000001997}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL
RC   Y-324 {ECO:0000313|Proteomes:UP000001997};
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L.,
RA   Agrafioti I., Arnaud M.B., Bates S., Brown A.J., Brunke S.,
RA   Costanzo M.C., Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L.,
RA   Hube B., Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R.,
RA   Neiman A.M., Nikolaou E., Quail M.A., Quinn J., Santos M.C.,
RA   Schmitzberger F.F., Sherlock G., Shah P., Silverstein K.A.,
RA   Skrzypek M.S., Soll D., Staggs R., Stansfield I., Stumpf M.P.,
RA   Sudbery P.E., Srikantha T., Zeng Q., Berman J., Berriman M.,
RA   Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000256|RuleBase:RU000617}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
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DR   EMBL; CH408157; EDK38885.2; -; Genomic_DNA.
DR   RefSeq; XP_001485254.1; XM_001485204.1.
DR   ProteinModelPortal; A5DI82; -.
DR   STRING; 4929.A5DI82; -.
DR   EnsemblFungi; EDK38885; EDK38885; PGUG_02983.
DR   GeneID; 5126991; -.
DR   KEGG; pgu:PGUG_02983; -.
DR   eggNOG; KOG0966; Eukaryota.
DR   eggNOG; COG1793; LUCA.
DR   InParanoid; A5DI82; -.
DR   KO; K10777; -.
DR   OrthoDB; EOG092C18KW; -.
DR   Proteomes; UP000001997; Unassembled WGS sequence.
DR   GO; GO:0032807; C:DNA ligase IV complex; IEA:EnsemblFungi.
DR   GO; GO:0000790; C:nuclear chromatin; IEA:EnsemblFungi.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:EnsemblFungi.
DR   GO; GO:0001302; P:replicative cell aging; IEA:EnsemblFungi.
DR   Gene3D; 3.40.50.10190; -; 2.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR029710; LIG4.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR10459:SF7; PTHR10459:SF7; 1.
DR   Pfam; PF16589; BRCT_2; 2.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SMART; SM00292; BRCT; 2.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF52113; SSF52113; 2.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS50172; BRCT; 2.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001997};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001997}.
FT   DOMAIN      381    509       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
FT   DOMAIN      659    758       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   DOMAIN      822    928       BRCT. {ECO:0000259|PROSITE:PS50172}.
SQ   SEQUENCE   937 AA;  107853 MW;  11DEFA0C58280A80 CRC64;
     MSYLDNVEAP KNHLDDADFD FLVSQLFTKV DGVSHQNLGE FPTISSKKVY VIEQFIKQWK
     TFIGPDIMPA APLIFPNKAK RLYYIRDTTL ARLVVKMLKI SPKSQDYDKL FKWKKHYHEY
     KHHHRRDTRN LKSLPFIIAQ IYSERRDPDK IVKPTIKISE VNKVLETLTT DEASKSAQQV
     AILEPVVEKL TIEQLRWFFT ILLKISTLGS FETAFFERWH PDAPRLYGLC NNLSKVFWLL
     TDPEVRLTDD QLTIQPFYPF LPQLSQKVNI SYEKLCARMN NAFYIEEKMD GDRMILHFQD
     SRFKFFSRRT KDYTLLYGAS FQIGSLTKYL TDAFHPRVKS IVLDGEMVAW DFKRKVILPF
     GTLKTSAVQE AVRQFTTTDV FEEQSAWPLF IVFDVLHVNG KNLTNHKLSY RKQLLRSLIN
     EIPHKFELLP LMKGSDPDDI KLAIKNVISD RGEGLVIKNV DSKYHVAQRD NSWVKVKPEY
     LEQFGENLDL VIIGLIPAVK NSYMCGLRDK ENGNVFKSFC TVANGFTEGE FDRLERLTAG
     KWNNLKTNPP PTDLIQFGRK KPDFWINPND SVALEIKARS IDVSLEETYA VGTTLHNLYC
     RRIRDDKLIE DCVTLQEYRE MKLKYSSDFN KSQTILQGRK RKANSFLLEQ ASKQVKTEVT
     SNLFSNFQFL ILSDCKKSRD NERLSVEDLS RIVKSHGGML IRSHKLAKEP DRQTIVISEV
     AIPSTEAIVN YGLDILKSVW VFNCIESNAI VPLEPSMIFR TRSVDLLKNS SARLDVYGDS
     FTQRVDLPIV EFCRRIENPQ LTDNDIKCAK EEFLHELGDN PPLAFLFNDV KFLIVAAHNW
     AKDGLRRKVE RYGGQISETL GDCSFVVVAN EEGDETLAAR IDVISHDIAD SVSFSNSSNL
     PIPSIVKSSF IDSCIEHRVL VDAADFSIGR KSKMRKN
//
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