ID A5KB81_PLAVS Unreviewed; 655 AA.
AC A5KB81;
DT 10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 10-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=glycerol-3-phosphate dehydrogenase {ECO:0000256|ARBA:ARBA00013029};
DE EC=1.1.5.3 {ECO:0000256|ARBA:ARBA00013029};
GN ORFNames=PVX_119445 {ECO:0000313|EMBL:EDL43359.1};
OS Plasmodium vivax (strain Salvador I).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=126793 {ECO:0000313|EMBL:EDL43359.1, ECO:0000313|Proteomes:UP000008333};
RN [1] {ECO:0000313|EMBL:EDL43359.1, ECO:0000313|Proteomes:UP000008333}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Salvador I {ECO:0000313|EMBL:EDL43359.1,
RC ECO:0000313|Proteomes:UP000008333};
RX PubMed=18843361; DOI=10.1038/nature07327;
RA Carlton J.M., Adams J.H., Silva J.C., Bidwell S.L., Lorenzi H., Caler E.,
RA Crabtree J., Angiuoli S.V., Merino E.F., Amedeo P., Cheng Q., Coulson R.M.,
RA Crabb B.S., Del Portillo H.A., Essien K., Feldblyum T.V.,
RA Fernandez-Becerra C., Gilson P.R., Gueye A.H., Guo X., Kang'a S.,
RA Kooij T.W., Korsinczky M., Meyer E.V., Nene V., Paulsen I., White O.,
RA Ralph S.A., Ren Q., Sargeant T.J., Salzberg S.L., Stoeckert C.J.,
RA Sullivan S.A., Yamamoto M.M., Hoffman S.L., Wortman J.R., Gardner M.J.,
RA Galinski M.R., Barnwell J.W., Fraser-Liggett C.M.;
RT "Comparative genomics of the neglected human malaria parasite Plasmodium
RT vivax.";
RL Nature 455:757-763(2008).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- SIMILARITY: Belongs to the FAD-dependent glycerol-3-phosphate
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00007330}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDL43359.1}.
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DR EMBL; AAKM01000017; EDL43359.1; -; Genomic_DNA.
DR RefSeq; XP_001613086.1; XM_001613036.1.
DR AlphaFoldDB; A5KB81; -.
DR STRING; 126793.A5KB81; -.
DR EnsemblProtists; EDL43359; EDL43359; PVX_119445.
DR GeneID; 5472340; -.
DR KEGG; pvx:PVX_119445; -.
DR VEuPathDB; PlasmoDB:PVX_119445; -.
DR InParanoid; A5KB81; -.
DR OMA; PHIVKPM; -.
DR PhylomeDB; A5KB81; -.
DR Proteomes; UP000008333; Chromosome 8.
DR GO; GO:0009331; C:glycerol-3-phosphate dehydrogenase complex; IEA:InterPro.
DR GO; GO:0004368; F:glycerol-3-phosphate dehydrogenase (quinone) activity; IEA:InterPro.
DR GO; GO:0006072; P:glycerol-3-phosphate metabolic process; IEA:InterPro.
DR Gene3D; 1.10.8.870; Alpha-glycerophosphate oxidase, cap domain; 1.
DR Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR031656; DAO_C.
DR InterPro; IPR038299; DAO_C_sf.
DR InterPro; IPR006076; FAD-dep_OxRdtase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR000447; G3P_DH_FAD-dep.
DR PANTHER; PTHR11985; GLYCEROL-3-PHOSPHATE DEHYDROGENASE; 1.
DR PANTHER; PTHR11985:SF15; GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR Pfam; PF01266; DAO; 1.
DR Pfam; PF16901; DAO_C; 1.
DR PRINTS; PR01001; FADG3PDH.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000008333}.
FT DOMAIN 59..403
FT /note="FAD dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF01266"
FT DOMAIN 503..637
FT /note="Alpha-glycerophosphate oxidase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16901"
FT REGION 408..457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..454
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 655 AA; 72471 MW; D11A3024F147F4F7 CRC64;
MLRKAIAASG GLGMIGAGGV YLLKVNFHKN MIDGDVEYKY SSVGSRSEMI SRLKRSQFDV
LIIGGGATGG GLALDCATRG IKCALIDKGD FSSGTSSKST KLLHGGIRYL ENAVKNLDLT
ELYFVWEALG ERAHAMKIAP FMSRAVPIIM PIYKYWQVPY FAYNIKVYDL LADLVCYFDK
GVPNSSYIRQ SNTVDGFPLL KKEQLKGSLV YYDGQHNDSR MNLNLILTSA MENYVPGQVG
ATVCNHVEVV GFLKDDDGRK IVGVRAVDRI SNKEMEIFAN VIVNATGPHG DVVRKLADET
ATPVIQTSSG CHFILPKWYS SKNNGIIIPK TSDGRVLFLL PWENATIVGT TDEQRQLEEN
PQIRKEDTNF LASELAKYIN VGADEIKSDI KAAWCGFRPL VMDPRGKKKL TQKAAGKGPH
EGEQSTAANA ANAANAANTA STASTAPNVT THELSRSHEI IEDDNGLISI LGGKWTIYRK
MAQDTLDYIA KKHCDRVRSK YNCRTKFLML VGSHDEQGKH NGDDLTYGSS KLSRKLVQKY
SQIDFDTAHH LVSNYGYLAE KVCELATELN LFNKIDASKP YIEAEVVYAS RHEFAATVSD
IIGRRFRLGF VDSAASAKVI TKIANLMKDE LSWSRDQVNR HVEDAKRYVR SLSLE
//
