ID   A5UA43_HAEIE            Unreviewed;       556 AA.
AC   A5UA43;
DT   10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT   10-JUL-2007, sequence version 1.
DT   01-MAY-2013, entry version 39.
DE   SubName: Full=1-phosphofructokinase;
DE            EC=2.7.1.56;
GN   Name=fruK; OrderedLocusNames=CGSHiEE_00760;
OS   Haemophilus influenzae (strain PittEE).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=374930;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PittEE;
RX   PubMed=17550610; DOI=10.1186/gb-2007-8-6-r103;
RA   Hogg J.S., Hu F.Z., Janto B., Boissy R., Hayes J., Keefe R.,
RA   Post J.C., Ehrlich G.D.;
RT   "Characterization and modeling of the Haemophilus influenzae core and
RT   supragenomes based on the complete genomic sequences of Rd and 12
RT   clinical nontypeable strains.";
RL   Genome Biol. 8:R103.1-R103.18(2007).
CC   -!- CATALYTIC ACTIVITY: Protein EIIB N(pi)-phospho-L-
CC       histidine/cysteine + sugar = protein EIIB + sugar phosphate.
CC   -!- SIMILARITY: Contains 1 PTS EIIB type-2 domain.
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DR   EMBL; CP000671; ABQ97644.1; -; Genomic_DNA.
DR   RefSeq; YP_001290027.1; NC_009566.1.
DR   ProteinModelPortal; A5UA43; -.
DR   STRING; 374930.CGSHiEE_00760; -.
DR   EnsemblBacteria; ABQ97644; ABQ97644; CGSHiEE_00760.
DR   GeneID; 5225336; -.
DR   KEGG; hip:CGSHiEE_00760; -.
DR   PATRIC; 20276300; VBIHaeInf81350_0152.
DR   eggNOG; COG1445; -.
DR   HOGENOM; HOG000227677; -.
DR   KO; K02769; -.
DR   KO; K02770; -.
DR   OMA; INHALLY; -.
DR   ProtClustDB; CLSK892369; -.
DR   BioCyc; HINF374930:GJDD-141-MONOMER; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008662; F:1-phosphofructokinase activity; IEA:EC.
DR   GO; GO:0008982; F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:InterPro.
DR   GO; GO:0005351; F:sugar:hydrogen symporter activity; IEA:InterPro.
DR   GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW.
DR   InterPro; IPR013011; PTS_EIIB_2.
DR   InterPro; IPR003501; PTS_EIIB_2/3.
DR   InterPro; IPR003352; PTS_EIIC.
DR   InterPro; IPR013014; PTS_EIIC_2.
DR   InterPro; IPR003353; PTS_IIB_fruc.
DR   InterPro; IPR006327; PTS_IIC_fruc.
DR   Pfam; PF02378; PTS_EIIC; 1.
DR   Pfam; PF02302; PTS_IIB; 1.
DR   TIGRFAMs; TIGR00829; FRU; 1.
DR   TIGRFAMs; TIGR01427; PTS_IIC_fructo; 1.
DR   PROSITE; PS51099; PTS_EIIB_TYPE_2; 1.
DR   PROSITE; PS51104; PTS_EIIC_TYPE_2; 1.
PE   4: Predicted;
KW   Cell membrane; Complete proteome; Kinase; Membrane;
KW   Phosphotransferase system; Sugar transport; Transferase;
KW   Transmembrane; Transmembrane helix; Transport.
SQ   SEQUENCE   556 AA;  57764 MW;  F89832C49106252F CRC64;
     MKLFLTQSAN VGNAKAYLLH EVFRAAAQKA NVSIVETAAE ADLVLVFGSV LPNNPDLVGK
     KVFIIGEAIA MISPEVTLAN ALANGADYVA PKSAVSFTGV SGVKNIVAVT ACPTGVAHTF
     MSAEAIEAYA KKQGWNVKVE TRGQVGTGNE ITAEEVAAAD LVFIAADIDV PLDKFKGKPM
     YRTSTGLALK KTEQEFDKAF KEAKVFDGGN NAGVKEESRE KKGVYKHLMT GVSHMLPLVV
     AGGLLIAISF MFSFNVIENT GVFQDLPNML MNIGSGVAFK LMIAVFAGYV AFSIADRPGL
     AVGLIAGMLA SEAGAGILGG IIAGFLAGYV VKGLNVIIRL PASLTSLKPI LILPLLGSMI
     VGLTMIYLIN PPVAEIMKEL SNWLTSMGEV NAIVLGAIIG AMMCIDMGGP VNKAAYTFSV
     GLIASQVYTP MAAAMAAGMV PPIGMAVATW IARNKFTVSQ RDAGKASFVL GLCFISEGAL
     PFVAADPIRV IISSVIGGAV AGAISMGLNI TLQAPHGGLF VIPFVSEPLK YLGAIAIGAL
     STGVVYAIIK SKNNAE
//