ID A5VM86_LACRD Unreviewed; 319 AA.
AC A5VM86;
DT 10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 10-JUL-2007, sequence version 1.
DT 01-MAY-2013, entry version 42.
DE RecName: Full=Cobalamin biosynthesis protein CobD;
GN Name=cobD; OrderedLocusNames=Lreu_1721;
OS Lactobacillus reuteri (strain DSM 20016).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactobacillus.
OX NCBI_TaxID=557436;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 20016;
RX PubMed=21379339; DOI=10.1371/journal.pgen.1001314;
RA Frese S.A., Benson A.K., Tannock G.W., Loach D.M., Kim J., Zhang M.,
RA Oh P.L., Heng N.C., Patil P.B., Juge N., Mackenzie D.A., Pearson B.M.,
RA Lapidus A., Dalin E., Tice H., Goltsman E., Land M., Hauser L.,
RA Ivanova N., Kyrpides N.C., Walter J.;
RT "The evolution of host specialization in the vertebrate gut symbiont
RT Lactobacillus reuteri.";
RL PLoS Genet. 7:E1001314-E1001314(2011).
CC -!- FUNCTION: Converts cobyric acid to cobinamide by the addition of
CC aminopropanol on the F carboxylic group (By similarity).
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC (By similarity).
CC -!- SIMILARITY: Belongs to the CobD/CbiB family.
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DR EMBL; CP000705; ABQ83960.1; -; Genomic_DNA.
DR RefSeq; YP_001272297.1; NC_009513.1.
DR STRING; 557436.Lreu_1721; -.
DR EnsemblBacteria; ABQ83960; ABQ83960; Lreu_1721.
DR GeneID; 5188933; -.
DR KEGG; lre:Lreu_1721; -.
DR PATRIC; 22256703; VBILacReu87937_1739.
DR eggNOG; COG1270; -.
DR HOGENOM; HOG000290070; -.
DR KO; K02227; -.
DR OMA; REFGWAS; -.
DR ProtClustDB; CLSK2326635; -.
DR UniPathway; UPA00148; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015420; F:cobalamin-transporting ATPase activity; IEA:HAMAP.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0048472; F:threonine-phosphate decarboxylase activity; IEA:InterPro.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR HAMAP; MF_00024; CobD_CbiB; 1; -.
DR InterPro; IPR004485; Cobalamin_biosynth_CobD/CbiB.
DR Pfam; PF03186; CobD_Cbib; 1.
DR TIGRFAMs; TIGR00380; cobD; 1.
PE 3: Inferred from homology;
KW Cell membrane; Cobalamin biosynthesis; Complete proteome; Ligase;
KW Membrane; Transmembrane; Transmembrane helix.
FT TRANSMEM 53 73 Helical; (By similarity).
FT TRANSMEM 76 96 Helical; (By similarity).
FT TRANSMEM 154 174 Helical; (By similarity).
FT TRANSMEM 204 224 Helical; (By similarity).
FT TRANSMEM 298 318 Helical; (By similarity).
SQ SEQUENCE 319 AA; 36044 MW; 24904A9F686BE7B3 CRC64;
MNILIMVILA FIFDFLLGDP HSWPHPVKAM GHLIAYLTKK FNRSNYSTKR KKWFGALTWL
ITVGGSGLIT YILMRFAAIN YYLYMIVGTY LCYTCLSMRQ LAIEAEKIMK SLQQNNLNKA
RQQVGMIVGR DTNQLSAEEV TKATIETVAE NTSDGVIAPL FFLVIGGPVL GIMYKAINTL
DSMIGYQNEK FRAFGEVSAR IDDIANYVPA RITWLLLIIS SWLLRDDTRE AIAVGERDCE
KHLSPNSAFS EAVVAGALHL QLGGPHYYFG ELVKKPYIGN DHLVIAANWH LKRTITMLYL
TSFLGLCGFE LIRFLIVWK
//
