ID A6M3I8_CLOB8 Unreviewed; 421 AA.
AC A6M3I8;
DT 24-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2007, sequence version 1.
DT 01-MAY-2013, entry version 49.
DE RecName: Full=UDP-N-acetylglucosamine 1-carboxyvinyltransferase;
DE EC=2.5.1.7;
DE AltName: Full=Enoylpyruvate transferase;
DE AltName: Full=UDP-N-acetylglucosamine enolpyruvyl transferase;
GN Name=murA; OrderedLocusNames=Cbei_5062;
OS Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium
OS acetobutylicum).
OC Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=290402;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51743 / NCIMB 8052;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA Pitluck S., Sims D., Brettin T., Bruce D., Tapia R., Brainard J.,
RA Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Mikhailova N., Bennet G., Cann I., Chen J.-S., Contreras A.L.,
RA Jones D., Kashket E., Mitchell W., Stoddard S., Schwarz W.,
RA Qureshi N., Young M., Shi Z., Ezeji T., White B., Blaschek H.,
RA Richardson P.;
RT "Complete sequence of Clostridium beijerinckii NCIMB 8052.";
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Cell wall formation. Adds enolpyruvyl to UDP-N-
CC acetylglucosamine (By similarity).
CC -!- CATALYTIC ACTIVITY: Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-
CC glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-
CC D-glucosamine.
CC -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the EPSP synthase family. MurA subfamily.
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DR EMBL; CP000721; ABR37168.1; -; Genomic_DNA.
DR RefSeq; YP_001312124.1; NC_009617.1.
DR ProteinModelPortal; A6M3I8; -.
DR STRING; 290402.Cbei_5062; -.
DR EnsemblBacteria; ABR37168; ABR37168; Cbei_5062.
DR GeneID; 5296214; -.
DR KEGG; cbe:Cbei_5062; -.
DR PATRIC; 19354536; VBICloBei69853_5258.
DR eggNOG; COG0766; -.
DR HOGENOM; HOG000075602; -.
DR KO; K00790; -.
DR OMA; AGACLMI; -.
DR ProtClustDB; PRK12830; -.
DR BioCyc; CBEI290402:GHL5-5201-MONOMER; -.
DR UniPathway; UPA00219; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008760; F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity; IEA:HAMAP.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:HAMAP.
DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR GO; GO:0019277; P:UDP-N-acetylgalactosamine biosynthetic process; IEA:InterPro.
DR Gene3D; 3.65.10.10; -; 2.
DR HAMAP; MF_00111; MurA; 1; -.
DR InterPro; IPR001986; Enolpyruvate_Tfrase_dom.
DR InterPro; IPR013792; RNA3'P_cycl/enolpyr_Trfase_a/b.
DR InterPro; IPR005750; UDP_GlcNAc_COvinyl_MurA.
DR PANTHER; PTHR21090:SF4; PTHR21090:SF4; 1.
DR Pfam; PF00275; EPSP_synthase; 1.
DR SUPFAM; SSF55205; RNA3'_cycl/enolpyr_transf_A/B; 1.
DR TIGRFAMs; TIGR01072; murA; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Cell shape;
KW Cell wall biogenesis/degradation; Complete proteome; Cytoplasm;
KW Peptidoglycan synthesis; Transferase.
FT ACT_SITE 118 118 Proton donor (By similarity).
FT MOD_RES 118 118 2-(S-cysteinyl)pyruvic acid O-
FT phosphothioketal (By similarity).
SQ SEQUENCE 421 AA; 45042 MW; 8DA827AFACA09596 CRC64;
MERLVINGGN LLEGTVDING AKNAAVAILP AAIMASDGKC IIDNIPDIED VHCLERILRS
LGCDIIKIDN NTLEIDSSNV NNFDACTDDV RRMRASYYFI GALLARFKKA RVVLPGGCSI
GVRPIDQHIK GFEALGADVF IEHGAVNVKA DKLVGANIFF DVVSVGATIN VMIAATLAEG
VTVLENVAKE PHVVDVANFL NSMGADIRGA GTDVIRIKGV ESLKGCSYSV IPDQIEAGTF
MIAAVATGGD VYIRNVIPKH LESITAKLTE MGAVIEEGDD CIRVTVKSPL KGVNIKTTPY
PGFPTDIQQP MSTLLSIVPG RSLITESIWE NRHKHIDELK KMGANIKVEG RVAIIDGAQK
LTGAVVKATD LRAGAAMVIA GLVAEGTTEI TSIEHIDRGY PHIENKFRAL GADIKRIEVD
E
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