GenomeNet

Database: UniProt/TrEMBL
Entry: A6QWB2_AJECN
LinkDB: A6QWB2_AJECN
Original site: A6QWB2_AJECN 
ID   A6QWB2_AJECN            Unreviewed;      1030 AA.
AC   A6QWB2;
DT   21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT   21-AUG-2007, sequence version 1.
DT   24-JAN-2024, entry version 77.
DE   RecName: Full=linoleate 8R-lipoxygenase {ECO:0000256|ARBA:ARBA00013239};
DE            EC=1.13.11.60 {ECO:0000256|ARBA:ARBA00013239};
GN   ORFNames=HCAG_01669 {ECO:0000313|EMBL:EDN03804.1};
OS   Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=2059318 {ECO:0000313|EMBL:EDN03804.1, ECO:0000313|Proteomes:UP000009297};
RN   [1] {ECO:0000313|Proteomes:UP000009297}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NAm1 / WU24 {ECO:0000313|Proteomes:UP000009297};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(9Z,12Z)-octadecadienoate + O2 = (8R,9Z,12Z)-8-
CC         hydroperoxyoctadeca-9,12-dienoate; Xref=Rhea:RHEA:25395,
CC         ChEBI:CHEBI:15379, ChEBI:CHEBI:30245, ChEBI:CHEBI:58659;
CC         EC=1.13.11.60; Evidence={ECO:0000256|ARBA:ARBA00000699};
CC   -!- COFACTOR:
CC       Name=heme b; Xref=ChEBI:CHEBI:60344;
CC         Evidence={ECO:0000256|ARBA:ARBA00001970};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH476655; EDN03804.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6QWB2; -.
DR   STRING; 339724.A6QWB2; -.
DR   VEuPathDB; FungiDB:HCAG_01669; -.
DR   HOGENOM; CLU_002329_1_0_1; -.
DR   OMA; KIQWDGD; -.
DR   OrthoDB; 3322316at2759; -.
DR   Proteomes; UP000009297; Unassembled WGS sequence.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0052878; F:linoleate 8R-lipoxygenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   GO; GO:0004601; F:peroxidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   CDD; cd20612; CYP_LDS-like_C; 1.
DR   CDD; cd09817; linoleate_diol_synthase_like; 1.
DR   Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR   Gene3D; 1.10.640.10; Haem peroxidase domain superfamily, animal type; 2.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   InterPro; IPR019791; Haem_peroxidase_animal.
DR   InterPro; IPR010255; Haem_peroxidase_sf.
DR   InterPro; IPR037120; Haem_peroxidase_sf_animal.
DR   InterPro; IPR034812; Ppo-like_N.
DR   PANTHER; PTHR11903; PROSTAGLANDIN G/H SYNTHASE; 1.
DR   PANTHER; PTHR11903:SF37; PSI-PRODUCING OXYGENASE A; 1.
DR   Pfam; PF03098; An_peroxidase; 1.
DR   Pfam; PF00067; p450; 1.
DR   SUPFAM; SSF48264; Cytochrome P450; 1.
DR   SUPFAM; SSF48113; Heme-dependent peroxidases; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   4: Predicted;
KW   Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW   Heme {ECO:0000256|PIRSR:PIRSR619791-2};
KW   Iron {ECO:0000256|PIRSR:PIRSR619791-2};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR619791-2};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Peroxidase {ECO:0000256|ARBA:ARBA00022559};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009297};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..1030
FT                   /note="linoleate 8R-lipoxygenase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002698845"
FT   BINDING         361
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR619791-2"
SQ   SEQUENCE   1030 AA;  115254 MW;  73D9F5B29088A843 CRC64;
     MTIGLKKWAV SLCARALLLP IVAAVKITSR MTGSCGKKAL REEIEDGVLK LSQLIHSLLR
     PLPTQTGDGT YVDETPPEPS LIDDLNQVDI KDLETLADVI RNAATGAPVN DKDYIMERII
     RLPSSLPSRS PNVDRLSNAL LSLLWNDLKH PPLSYLGEQT SFGHKLALQV LHMQGLYHRS
     RSNQQCSQIR GSFSIIYSAL TAMIIHLAPL YGSNQEEQNT VRTFKGGKLK PDCFSEKRIL
     GFPPGVGVLL IMFNRFHNYV VENLALINQD NRFPKPAEPS GKAYAKYDND LFQTGRLITC
     GLYINIILKD YLRTILNINR TDSDWSLDPR SESMRGLFGT AIDEAGGNQV SAEFNLVYRW
     HSCVSERDDK WTQNAYRELF GDGMDPNKIS LSDFLRVLGK WEAGLSKDPL KRPFAKLARG
     SNGLFNDDDL ANILTESIED CAGPFGTSQI PAVFRAVEIL GINQARHGDF RASTNNVELY
     PGPIAEEAKE SLVPGSGLCA NFTISRAILS DAVALVRGDR FYTVDQTPKN LTNWGFNEAS
     YDNTVDKGHV FYKLFLRAFP SHFKPNSIYA HFPLVVPDEN REILTRLNSS RKYSWDKPAR
     IPRPTMIESY AACDAIIKNQ KDFKVTWGEA IEFLMHKECH SFGRDFMLSG DEPPNAASRQ
     MMGRALYHGE WEAEVKKFYE QITLKLLHAK SYKIAGVNQV DIVRDVANIA QVHFAVAVFG
     LPLKTGDNPR GIYTESELYM IMALVFACIF FDADPAKSFP LRQRARKVTQ QLGDIVLLNV
     QLIKQTGFLS NMVERLYGNN MLTEYGVHMI RRLLDSGLPP EQIVWTHMLP TAGGMVANQA
     QLFSQCLDYY LSEEGSIHLP EIHRLSKLGT AEADELLLKY FLEGSRLRAT VGVYREVVTQ
     STIKDGVKTL SLKPGDRVAC NFAKASMDPK KFPEPDKVDL TRDLDSYIHF GQGPHKCLGF
     GICNAALSTM LKTVGKLENL RRAPGPQGEL RRIPGPGGIS KYLVVDYTSY FPFPTTMKVQ
     WDGELPPCAN
//
DBGET integrated database retrieval system