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Database: UniProt/TrEMBL
Entry: A6QZ20_AJECN
LinkDB: A6QZ20_AJECN
Original site: A6QZ20_AJECN 
ID   A6QZ20_AJECN            Unreviewed;       972 AA.
AC   A6QZ20;
DT   21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT   21-AUG-2007, sequence version 1.
DT   07-JUN-2017, entry version 60.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   ORFNames=HCAG_02627 {ECO:0000313|EMBL:EDN06024.1};
OS   Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=339724 {ECO:0000313|EMBL:EDN06024.1, ECO:0000313|Proteomes:UP000009297};
RN   [1] {ECO:0000313|Proteomes:UP000009297}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NAm1 / WU24 {ECO:0000313|Proteomes:UP000009297};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J.,
RA   Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E.,
RA   Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M.,
RA   Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N., Orbach M.J.,
RA   Kirkland T.N., Cole G.T., Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens
RT   Coccidioides and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000256|RuleBase:RU000617}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
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DR   EMBL; CH476656; EDN06024.1; -; Genomic_DNA.
DR   RefSeq; XP_001542456.1; XM_001542406.1.
DR   STRING; 339724.XP_001542456.1; -.
DR   PRIDE; A6QZ20; -.
DR   EnsemblFungi; EDN06024; EDN06024; HCAG_02627.
DR   GeneID; 5448693; -.
DR   KEGG; aje:HCAG_02627; -.
DR   EuPathDB; FungiDB:HCAG_02627; -.
DR   eggNOG; KOG0966; Eukaryota.
DR   eggNOG; COG1793; LUCA.
DR   KO; K10777; -.
DR   OrthoDB; EOG092C18KW; -.
DR   Proteomes; UP000009297; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.3260.10; -; 1.
DR   Gene3D; 3.40.50.10190; -; 2.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR029710; LIG4.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR10459:SF84; PTHR10459:SF84; 1.
DR   Pfam; PF16589; BRCT_2; 1.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SUPFAM; SSF117018; SSF117018; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF52113; SSF52113; 1.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS50172; BRCT; 2.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009297};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009297}.
FT   DOMAIN      425    550       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
FT   DOMAIN      719    820       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   DOMAIN      850    971       BRCT. {ECO:0000259|PROSITE:PS50172}.
SQ   SEQUENCE   972 AA;  110245 MW;  75EE296AB02C7DA5 CRC64;
     MDSDGEGEPN GSRQQDSTAN DLDEKYPNPP RNHSPTLPFH DLFLTLFNPL NENKKRPTGP
     AAARRKVGPH GQGAAVHLSP QERRRDIIQR FISRWRKEVG DDIFPAFRLI IPEKDRDRAM
     YGLKEKAIGK LLVKVMKIDK NSEDGFSLLN WKVPGQSFAS RMAGDFAGRC FEVISKRPLR
     TEVGDMTIDE VNEQLDKLSA ASKEDEQVPI LAYFYRRMNP EELMWLIRII LRQMKVGATE
     RTFFSIWHPD AEALFSISSS LRRVCWQLYN TDVRLEGDET KVTLMQCFQP QLAQFQMQSF
     EHMIRRMRLT EDDPTFWIEE KLDGERIQLH MKPDDSIPGG KRFGFWSRKA KEYTYLYGNG
     LLDENGALTR HLQDAFADGV QSIILDGEMI TWDPEHDAIV PFGTLKTAAL AEQRNPFSTG
     QRPLFRIFDI LYLNGRPLTR YTLKDRRKAL EASVIPVHRR FEIHTYDIGH SATDIDPLLR
     KVVAEASEGL VLKNPNSPYR LNERHDDWMK VKPEYMTDFG ESLDCIVIGG YYGSGRRGGA
     LSSFLCGLRV DGSHSKTGDH PTKCYSFCKV GGGFTAADYA NIRHHTDGKW MDWDPKRPPT
     EYIELAGGDL QYERPDVWIK PEDSVVLCVK ASSVTSTDQF RLGLTVRFPR FKRLRMDKDW
     RSALSIQEFM DLKSNVEREV KEKEFKVDDS RKVRHRKAIK KPLTIAGYDG GKKLEYVGPS
     GTLFDGLNFF IMTESVHQPK KTKAQLEQLV KANGGKIYQT NNVAENTICI ADRTDQEEEI
     AEHVDKYSDS YARDIDASEL KKLLDSMHPA PALPPSSLSE LESQLESHSL NERKPATPTI
     SNTSTCPGWL FKGLVIYFAM PPSLSNEGNG KIPHVLPQRL YLASNLVKFA GGEVITDDDG
     DMKDARITHV VVDSNPPGDK AAMAAADVAG IRRAISSRAG VGKRIPHIVG VEWVEESWGE
     RTLVDEERFT PK
//
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