ID A6R0U9_AJECN Unreviewed; 444 AA.
AC A6R0U9;
DT 21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT 21-AUG-2007, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=3-hydroxyisobutyrate dehydrogenase {ECO:0008006|Google:ProtNLM};
GN ORFNames=HCAG_03256 {ECO:0000313|EMBL:EDN06726.1};
OS Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=2059318 {ECO:0000313|EMBL:EDN06726.1, ECO:0000313|Proteomes:UP000009297};
RN [1] {ECO:0000313|Proteomes:UP000009297}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NAm1 / WU24 {ECO:0000313|Proteomes:UP000009297};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
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DR EMBL; CH476657; EDN06726.1; -; Genomic_DNA.
DR AlphaFoldDB; A6R0U9; -.
DR STRING; 339724.A6R0U9; -.
DR VEuPathDB; FungiDB:HCAG_03256; -.
DR HOGENOM; CLU_035117_1_2_1; -.
DR OMA; QMFMQAS; -.
DR OrthoDB; 1121581at2759; -.
DR Proteomes; UP000009297; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 2.
DR Pfam; PF03446; NAD_binding_2; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009297}.
FT DOMAIN 7..165
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 176..297
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT DOMAIN 317..440
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
SQ SEQUENCE 444 AA; 46449 MW; 2DDBF411CA525AB0 CRC64;
MATEKPSIGF VGLGLMGFGM ATNLIKLGYV VKGYDIQETT MARFKDAGGQ IASSPGGAAG
GNMFCVCMVA TAAQAQVAIF DHENGIAKGL PSGATLILCS TVSAVSAQSY RDQLVSIGRE
DVYFIDAPVS GGARKAGEGT LTIMAGGSDA ALEEGKFLLT EMADTNKLYF VPGGVGAGSN
MKMIHQVFAA IHILAASEVM GFAAHLGLNA EEAGKAVTSS LAWSFMHENR CERMLREDYY
PGASAITIIL KDVGIVTAAA RLHNFPTPLC SIAEQIFITA LPLGFGGDDD ASAVRLYYRD
PITNAEPKAS LNPKSNAAAL KLIVNLLTNI HLIAAAEAIA FARLLKVDLQ LVYAVVNAAA
GASTIFKLRG EGMIAELTGG FDSGSTKTVN EATAELAAVV QAARDVYCPL HMGNAALNIL
YLAQKQGLGE KTDSHILRVY ENGE
//
