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Database: UniProt/TrEMBL
Entry: A6R203_AJECN
LinkDB: A6R203_AJECN
Original site: A6R203_AJECN 
ID   A6R203_AJECN            Unreviewed;       460 AA.
AC   A6R203;
DT   21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT   21-AUG-2007, sequence version 1.
DT   25-OCT-2017, entry version 57.
DE   RecName: Full=Phosphotransferase {ECO:0000256|RuleBase:RU362007};
DE            EC=2.7.1.- {ECO:0000256|RuleBase:RU362007};
GN   ORFNames=HCAG_03661 {ECO:0000313|EMBL:EDN07130.1};
OS   Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=339724 {ECO:0000313|EMBL:EDN07130.1, ECO:0000313|Proteomes:UP000009297};
RN   [1] {ECO:0000313|Proteomes:UP000009297}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NAm1 / WU24 {ECO:0000313|Proteomes:UP000009297};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J.,
RA   Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E.,
RA   Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M.,
RA   Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N., Orbach M.J.,
RA   Kirkland T.N., Cole G.T., Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens
RT   Coccidioides and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- SIMILARITY: Belongs to the hexokinase family.
CC       {ECO:0000256|RuleBase:RU362007, ECO:0000256|SAAS:SAAS00672880}.
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DR   EMBL; CH476657; EDN07130.1; -; Genomic_DNA.
DR   RefSeq; XP_001541563.1; XM_001541513.1.
DR   ProteinModelPortal; A6R203; -.
DR   STRING; 339724.XP_001541563.1; -.
DR   EnsemblFungi; EDN07130; EDN07130; HCAG_03661.
DR   GeneID; 5447546; -.
DR   KEGG; aje:HCAG_03661; -.
DR   EuPathDB; FungiDB:HCAG_03661; -.
DR   eggNOG; KOG1369; Eukaryota.
DR   eggNOG; COG5026; LUCA.
DR   KO; K00844; -.
DR   OrthoDB; EOG092C2JW4; -.
DR   Proteomes; UP000009297; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR   GO; GO:0005634; C:nucleus; IEA:EnsemblFungi.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008865; F:fructokinase activity; IEA:EnsemblFungi.
DR   GO; GO:0004340; F:glucokinase activity; IEA:EnsemblFungi.
DR   GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR   GO; GO:0019158; F:mannokinase activity; IEA:EnsemblFungi.
DR   GO; GO:0001678; P:cellular glucose homeostasis; IEA:InterPro.
DR   GO; GO:0006002; P:fructose 6-phosphate metabolic process; IEA:EnsemblFungi.
DR   GO; GO:0006000; P:fructose metabolic process; IEA:EnsemblFungi.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:EnsemblFungi.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-KW.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:EnsemblFungi.
DR   InterPro; IPR001312; Hexokinase.
DR   InterPro; IPR019807; Hexokinase_BS.
DR   InterPro; IPR022673; Hexokinase_C.
DR   InterPro; IPR022672; Hexokinase_N.
DR   PANTHER; PTHR19443; PTHR19443; 3.
DR   Pfam; PF00349; Hexokinase_1; 1.
DR   Pfam; PF03727; Hexokinase_2; 2.
DR   PROSITE; PS00378; HEXOKINASE_1; 1.
DR   PROSITE; PS51748; HEXOKINASE_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU362007,
KW   ECO:0000256|SAAS:SAAS00672869};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009297};
KW   Glycolysis {ECO:0000256|RuleBase:RU362007,
KW   ECO:0000256|SAAS:SAAS00672870};
KW   Kinase {ECO:0000256|RuleBase:RU362007, ECO:0000256|SAAS:SAAS00672871,
KW   ECO:0000313|EMBL:EDN07130.1};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU362007,
KW   ECO:0000256|SAAS:SAAS00672883};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009297};
KW   Transferase {ECO:0000256|RuleBase:RU362007,
KW   ECO:0000256|SAAS:SAAS00672884}.
FT   DOMAIN       26    241       Hexokinase_1. {ECO:0000259|Pfam:PF00349}.
FT   DOMAIN      247    304       Hexokinase_2. {ECO:0000259|Pfam:PF03727}.
FT   DOMAIN      307    439       Hexokinase_2. {ECO:0000259|Pfam:PF03727}.
SQ   SEQUENCE   460 AA;  51010 MW;  E9AB67914CC24D87 CRC64;
     MAITPRRKPS RKGSMADMPK DVLDQLKTLE ELFTVDQEKL KQIVEHFIKE LQKGLSVEGG
     NIPMNVTWVL GFPTGHEKGT FLALDMGGTN LRVCEIELSE EKGEFDVTQS KYRIPEELKS
     GESSELWEYI ADCVQQFIEY YHDGCTALPD LPLGFTFSYP ATQEYVDHGV LQRWTKGFDI
     DGVEGKDVVP MLEEALAKKV KNSALSPFFF GYMVLITLQG LPIKVAALVN DTTGTLIASA
     YTDPEMKIGC IFGTGVNAAY MENAGSIPKI AHYNLPPDTP VAINCEYGAF DNELIVLPRT
     QYDDVSQLRK PYSLDSSFLA FIEEDPFENL SETRDLFERT LGIYALPSEL EFCRRLAELI
     GTRAARLSAC GVAAICKKKN ITHCHVGADG SVFEKYPHFK ARGARALREI LDWPDSEPDR
     VVMSGAEDGS GVGAALIAAL TLERVKQASW EWKYIGSGLS
//
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