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Database: UniProt/TrEMBL
Entry: A6SUB5_JANMA
LinkDB: A6SUB5_JANMA
Original site: A6SUB5_JANMA 
ID   A6SUB5_JANMA            Unreviewed;       318 AA.
AC   A6SUB5;
DT   21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT   21-AUG-2007, sequence version 1.
DT   19-FEB-2014, entry version 49.
DE   RecName: Full=Glutathione synthetase;
DE            EC=6.3.2.3;
DE   AltName: Full=GSH synthetase;
DE   AltName: Full=Glutathione synthase;
GN   Name=gshB; OrderedLocusNames=mma_0172;
OS   Janthinobacterium sp. (strain Marseille) (Minibacterium massiliensis).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Oxalobacteraceae; Janthinobacterium.
OX   NCBI_TaxID=375286;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Marseille;
RX   PubMed=17722982; DOI=10.1371/journal.pgen.0030138;
RA   Audic S., Robert C., Campagna B., Parinello H., Claverie J.-M.,
RA   Raoult D., Drancourt M.;
RT   "Genome analysis of Minibacterium massiliensis highlights the
RT   convergent evolution of water-living bacteria.";
RL   PLoS Genet. 3:1454-1463(2007).
CC   -!- CATALYTIC ACTIVITY: ATP + gamma-L-glutamyl-L-cysteine + glycine =
CC       ADP + phosphate + glutathione.
CC   -!- COFACTOR: Binds 1 magnesium or manganese ion per subunit (By
CC       similarity).
CC   -!- PATHWAY: Sulfur metabolism; glutathione biosynthesis; glutathione
CC       from L-cysteine and L-glutamate: step 2/2.
CC   -!- SIMILARITY: Belongs to the prokaryotic GSH synthase family.
CC   -!- SIMILARITY: Contains 1 ATP-grasp domain.
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DR   EMBL; CP000269; ABR89170.1; -; Genomic_DNA.
DR   RefSeq; YP_001351862.1; NC_009659.1.
DR   ProteinModelPortal; A6SUB5; -.
DR   STRING; 375286.mma_0172; -.
DR   EnsemblBacteria; ABR89170; ABR89170; mma_0172.
DR   GeneID; 5350060; -.
DR   KEGG; mms:mma_0172; -.
DR   PATRIC; 22152743; VBIJanSp106498_0177.
DR   eggNOG; COG0189; -.
DR   HOGENOM; HOG000265022; -.
DR   KO; K01920; -.
DR   OMA; PTCFQEI; -.
DR   OrthoDB; EOG6WMHWB; -.
DR   ProtClustDB; CLSK966482; -.
DR   BioCyc; JSP375286:GJ8U-172-MONOMER; -.
DR   UniPathway; UPA00142; UER00210.
DR   GO; GO:0005829; C:cytosol; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0004363; F:glutathione synthase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-HAMAP.
DR   Gene3D; 3.30.1490.20; -; 1.
DR   Gene3D; 3.30.470.20; -; 1.
DR   Gene3D; 3.40.50.20; -; 1.
DR   HAMAP; MF_00162; GSH_S; 1.
DR   InterPro; IPR011761; ATP-grasp.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR013816; ATP_grasp_subdomain_2.
DR   InterPro; IPR006284; Glut_synth_pro.
DR   InterPro; IPR004218; GSHS_ATP-bd.
DR   InterPro; IPR004215; GSHS_N.
DR   InterPro; IPR016185; PreATP-grasp_dom.
DR   Pfam; PF02955; GSH-S_ATP; 1.
DR   Pfam; PF02951; GSH-S_N; 1.
DR   SUPFAM; SSF52440; SSF52440; 1.
DR   TIGRFAMs; TIGR01380; glut_syn; 1.
DR   PROSITE; PS50975; ATP_GRASP; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Glutathione biosynthesis; Ligase;
KW   Magnesium; Manganese; Metal-binding; Nucleotide-binding.
FT   DOMAIN      125    310       ATP-grasp (By similarity).
FT   NP_BIND     151    207       ATP (By similarity).
FT   METAL       281    281       Magnesium or manganese (By similarity).
FT   METAL       283    283       Magnesium or manganese (By similarity).
SQ   SEQUENCE   318 AA;  35067 MW;  CE7E8D68CEEE5F7A CRC64;
     MKLAFVADPL DGFKIYKDST YAMMAEAARR GHTIHVFQHK DMAFEGGKVI ANVSRVTLTG
     GGQEDWYQQD APTVQELTTF DAILERTDPP FNMEYIYATY LLELAQQQGA RIFNKPEAVR
     SFNEKLAIAQ FPQYIAPTLV TSDAARVRAF HAEHRDIILK PLDGMGGAGI FRVKDDALNL
     GSIIETLSDN GRRTIMVQRY IPEITDGDKR ILLIGGQVVP YCLARIPQGT EIRGNLAVGG
     IGVAREISAR DREIGEALAP LLLKRGLLLV GLDAIGSYMT ELNVTSPTCF QEIKQQTGFD
     VAAMFIDALE KNVAGWNS
//
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