ID A6WT99_SHEB8 Unreviewed; 432 AA.
AC A6WT99;
DT 21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT 21-AUG-2007, sequence version 1.
DT 01-MAY-2013, entry version 43.
DE RecName: Full=Phosphoribosylamine--glycine ligase;
DE EC=6.3.4.13;
DE AltName: Full=GARS;
DE AltName: Full=Glycinamide ribonucleotide synthetase;
DE AltName: Full=Phosphoribosylglycinamide synthetase;
GN Name=purD; OrderedLocusNames=Shew185_3914;
OS Shewanella baltica (strain OS185).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC Shewanellaceae; Shewanella.
OX NCBI_TaxID=402882;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OS185;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T.,
RA Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D.,
RA Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA Kyrpides N., Mikhailova N., Brettar I., Rodrigues J.,
RA Konstantinidis K., Tiedje J., Richardson P.;
RT "Complete sequence of chromosome of Shewanella baltica OS185.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY: ATP + 5-phospho-D-ribosylamine + glycine = ADP
CC + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide.
CC -!- COFACTOR: Binds (magnesium or manganese,ion) per subunit (By
CC similarity).
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-
CC ribose 1-diphosphate: step 2/2.
CC -!- SIMILARITY: Belongs to the GARS family.
CC -!- SIMILARITY: Contains 1 ATP-grasp domain.
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DR EMBL; CP000753; ABS10038.1; -; Genomic_DNA.
DR RefSeq; YP_001368101.1; NC_009665.1.
DR ProteinModelPortal; A6WT99; -.
DR SMR; A6WT99; 1-428.
DR STRING; 402882.Shew185_3914; -.
DR EnsemblBacteria; ABS10038; ABS10038; Shew185_3914.
DR GeneID; 5371187; -.
DR KEGG; sbm:Shew185_3914; -.
DR PATRIC; 23464907; VBISheBal127872_4196.
DR eggNOG; COG0151; -.
DR HOGENOM; HOG000033463; -.
DR KO; K01945; -.
DR OMA; MGAYTPL; -.
DR ProtClustDB; PRK00885; -.
DR BioCyc; SBAL402882:GJ99-4038-MONOMER; -.
DR UniPathway; UPA00074; UER00125.
DR GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR GO; GO:0000287; F:magnesium ion binding; IEA:HAMAP.
DR GO; GO:0030145; F:manganese ion binding; IEA:HAMAP.
DR GO; GO:0004637; F:phosphoribosylamine-glycine ligase activity; IEA:HAMAP.
DR GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0009113; P:purine nucleobase biosynthetic process; IEA:InterPro.
DR Gene3D; 3.30.1490.20; -; 1.
DR Gene3D; 3.30.470.20; -; 1.
DR Gene3D; 3.40.50.20; -; 1.
DR Gene3D; 3.90.600.10; -; 1.
DR HAMAP; MF_00138; GARS; 1; -.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR013816; ATP_grasp_subdomain_2.
DR InterPro; IPR016185; PreATP-grasp_dom.
DR InterPro; IPR020561; PRibGlycinamid_synth_ATP-grasp.
DR InterPro; IPR000115; PRibGlycinamide_synth.
DR InterPro; IPR020560; PRibGlycinamide_synth_C-dom.
DR InterPro; IPR020559; PRibGlycinamide_synth_CS.
DR InterPro; IPR020562; PRibGlycinamide_synth_N.
DR InterPro; IPR011054; Rudment_hybrid_motif.
DR Pfam; PF01071; GARS_A; 1.
DR Pfam; PF02843; GARS_C; 1.
DR Pfam; PF02844; GARS_N; 1.
DR SUPFAM; SSF52440; PreATP-grasp-like; 1.
DR SUPFAM; SSF51246; Rudmnt_hyb_motif; 1.
DR TIGRFAMs; TIGR00877; purD; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS00184; GARS; 1.
PE 3: Inferred from homology;
KW ATP-binding; Complete proteome; Ligase; Magnesium; Manganese;
KW Metal-binding; Nucleotide-binding; Purine biosynthesis.
FT DOMAIN 109 320 ATP-grasp (By similarity).
FT NP_BIND 139 200 ATP (By similarity).
FT METAL 290 290 Magnesium or manganese (By similarity).
FT METAL 292 292 Magnesium or manganese (By similarity).
SQ SEQUENCE 432 AA; 45791 MW; FF7EBCBF6D541796 CRC64;
MKVLVIGGGG REHALAWKAA QSAQVETVYV APGNAGTALE PNVENLAISA TDIPALLDFA
KTNKIELTIV GPEAPLVMGV VDAFNAAGLP IFGPTKAAAQ LEGSKAFTKD FLARHNIPTA
GYKNCTEIRD AKAFVRELTA TTGYPVVIKA DGLAAGKGVI IAQDQAEADA AIDDMLAGNK
FGDAGSRVVI EEFLKGEEAS FIVMVDGKNI LPMATSQDHK ARDNGDYGPN TGGMGAYSPA
PVVTQAVHDW TVANVIRPTV DGMAAEGNIY TGFLYAGLMI SPDGSAKVLE YNCRFGDPET
QPIMMRLKSD LVELCLAATR GELDKVTAEY DERAAVGVVL AAGGYPDEYR KFDVIDGLSL
GDNNGKVFHA GTEMKDGHVV TNGGRVLCAT ALGNTVTEAQ KAAYKLVDEI HWDDVYFRTD
IGYRAIAREQ QD
//
