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Database: UniProt/TrEMBL
Entry: A6WT99_SHEB8
LinkDB: A6WT99_SHEB8
Original site: A6WT99_SHEB8 
ID   A6WT99_SHEB8            Unreviewed;       432 AA.
AC   A6WT99;
DT   21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT   21-AUG-2007, sequence version 1.
DT   11-JUN-2014, entry version 49.
DE   RecName: Full=Phosphoribosylamine--glycine ligase;
DE            EC=6.3.4.13;
DE   AltName: Full=GARS;
DE   AltName: Full=Glycinamide ribonucleotide synthetase;
DE   AltName: Full=Phosphoribosylglycinamide synthetase;
GN   Name=purD; OrderedLocusNames=Shew185_3914;
OS   Shewanella baltica (strain OS185).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=402882;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OS185;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T.,
RA   Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D.,
RA   Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Mikhailova N., Brettar I., Rodrigues J.,
RA   Konstantinidis K., Tiedje J., Richardson P.;
RT   "Complete sequence of chromosome of Shewanella baltica OS185.";
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: ATP + 5-phospho-D-ribosylamine + glycine = ADP
CC       + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide.
CC   -!- COFACTOR: Binds 1 magnesium or manganese ion per subunit (By
CC       similarity).
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-
CC       ribose 1-diphosphate: step 2/2.
CC   -!- SIMILARITY: Belongs to the GARS family.
CC   -!- SIMILARITY: Contains 1 ATP-grasp domain.
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DR   EMBL; CP000753; ABS10038.1; -; Genomic_DNA.
DR   RefSeq; YP_001368101.1; NC_009665.1.
DR   ProteinModelPortal; A6WT99; -.
DR   SMR; A6WT99; 1-428.
DR   STRING; 402882.Shew185_3914; -.
DR   EnsemblBacteria; ABS10038; ABS10038; Shew185_3914.
DR   GeneID; 5371187; -.
DR   KEGG; sbm:Shew185_3914; -.
DR   PATRIC; 23464907; VBISheBal127872_4196.
DR   eggNOG; COG0151; -.
DR   HOGENOM; HOG000033463; -.
DR   KO; K01945; -.
DR   OMA; YKGFLYA; -.
DR   OrthoDB; EOG69SKD1; -.
DR   BioCyc; SBAL402882:GJ99-4038-MONOMER; -.
DR   UniPathway; UPA00074; UER00125.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0004637; F:phosphoribosylamine-glycine ligase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0009113; P:purine nucleobase biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.30.1490.20; -; 1.
DR   Gene3D; 3.30.470.20; -; 1.
DR   Gene3D; 3.40.50.20; -; 1.
DR   Gene3D; 3.90.600.10; -; 1.
DR   HAMAP; MF_00138; GARS; 1.
DR   InterPro; IPR011761; ATP-grasp.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR013816; ATP_grasp_subdomain_2.
DR   InterPro; IPR016185; PreATP-grasp_dom.
DR   InterPro; IPR020561; PRibGlycinamid_synth_ATP-grasp.
DR   InterPro; IPR000115; PRibGlycinamide_synth.
DR   InterPro; IPR020560; PRibGlycinamide_synth_C-dom.
DR   InterPro; IPR020559; PRibGlycinamide_synth_CS.
DR   InterPro; IPR020562; PRibGlycinamide_synth_N.
DR   InterPro; IPR011054; Rudment_hybrid_motif.
DR   Pfam; PF01071; GARS_A; 1.
DR   Pfam; PF02843; GARS_C; 1.
DR   Pfam; PF02844; GARS_N; 1.
DR   SUPFAM; SSF51246; SSF51246; 1.
DR   SUPFAM; SSF52440; SSF52440; 1.
DR   TIGRFAMs; TIGR00877; purD; 1.
DR   PROSITE; PS50975; ATP_GRASP; 1.
DR   PROSITE; PS00184; GARS; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Ligase; Magnesium; Manganese;
KW   Metal-binding; Nucleotide-binding; Purine biosynthesis.
FT   DOMAIN      109    320       ATP-grasp (By similarity).
FT   NP_BIND     139    200       ATP (By similarity){EA2}.
FT   METAL       290    290       Magnesium or manganese (By
FT                                similarity){EA2}.
FT   METAL       292    292       Magnesium or manganese (By
FT                                similarity){EA2}.
SQ   SEQUENCE   432 AA;  45791 MW;  FF7EBCBF6D541796 CRC64;
     MKVLVIGGGG REHALAWKAA QSAQVETVYV APGNAGTALE PNVENLAISA TDIPALLDFA
     KTNKIELTIV GPEAPLVMGV VDAFNAAGLP IFGPTKAAAQ LEGSKAFTKD FLARHNIPTA
     GYKNCTEIRD AKAFVRELTA TTGYPVVIKA DGLAAGKGVI IAQDQAEADA AIDDMLAGNK
     FGDAGSRVVI EEFLKGEEAS FIVMVDGKNI LPMATSQDHK ARDNGDYGPN TGGMGAYSPA
     PVVTQAVHDW TVANVIRPTV DGMAAEGNIY TGFLYAGLMI SPDGSAKVLE YNCRFGDPET
     QPIMMRLKSD LVELCLAATR GELDKVTAEY DERAAVGVVL AAGGYPDEYR KFDVIDGLSL
     GDNNGKVFHA GTEMKDGHVV TNGGRVLCAT ALGNTVTEAQ KAAYKLVDEI HWDDVYFRTD
     IGYRAIAREQ QD
//
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