GenomeNet

Database: UniProt/TrEMBL
Entry: A7FKJ1_YERP3
LinkDB: A7FKJ1_YERP3
Original site: A7FKJ1_YERP3 
ID   A7FKJ1_YERP3            Unreviewed;       570 AA.
AC   A7FKJ1;
DT   11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT   11-SEP-2007, sequence version 1.
DT   26-NOV-2014, entry version 54.
DE   RecName: Full=D-lactate dehydrogenase {ECO:0000256|PIRNR:PIRNR000101};
DE            EC=1.1.1.28 {ECO:0000256|PIRNR:PIRNR000101};
GN   Name=dld {ECO:0000313|EMBL:ABS49402.1};
GN   OrderedLocusNames=YpsIP31758_2805 {ECO:0000313|EMBL:ABS49402.1};
OS   Yersinia pseudotuberculosis serotype O:1b (strain IP 31758).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Yersinia.
OX   NCBI_TaxID=349747 {ECO:0000313|EMBL:ABS49402.1, ECO:0000313|Proteomes:UP000002412};
RN   [1] {ECO:0000313|EMBL:ABS49402.1, ECO:0000313|Proteomes:UP000002412}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IP 31758 {ECO:0000313|EMBL:ABS49402.1,
RC   ECO:0000313|Proteomes:UP000002412};
RX   PubMed=17784789; DOI=10.1371/journal.pgen.0030142;
RA   Eppinger M., Rosovitz M.J., Fricke W.F., Rasko D.A., Kokorina G.,
RA   Fayolle C., Lindler L.E., Carniel E., Ravel J.;
RT   "The complete genome sequence of Yersinia pseudotuberculosis IP31758,
RT   the causative agent of Far East scarlet-like fever.";
RL   PLoS Genet. 3:1508-1523(2007).
CC   -!- FUNCTION: First component of the membrane-bound D-lactate oxidase,
CC       which is believed to play an important role in the energization of
CC       the active transport of a variety of sugars and amino acids.
CC       {ECO:0000256|PIRNR:PIRNR000101}.
CC   -!- CATALYTIC ACTIVITY: (R)-lactate + NAD(+) = pyruvate + NADH.
CC       {ECO:0000256|PIRNR:PIRNR000101}.
CC   -!- COFACTOR:
CC       Note=FAD. {ECO:0000256|PIRNR:PIRNR000101};
CC   -!- SIMILARITY: Contains FAD-binding PCMH-type domain.
CC       {ECO:0000256|SAAS:SAAS00083646}.
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DR   EMBL; CP000720; ABS49402.1; -; Genomic_DNA.
DR   RefSeq; WP_012105463.1; NC_009708.1.
DR   RefSeq; YP_001401769.1; NC_009708.1.
DR   ProteinModelPortal; A7FKJ1; -.
DR   SMR; A7FKJ1; 10-567.
DR   STRING; 349747.YpsIP31758_2805; -.
DR   EnsemblBacteria; ABS49402; ABS49402; YpsIP31758_2805.
DR   GeneID; 5388054; -.
DR   KEGG; ypi:YpsIP31758_2805; -.
DR   PATRIC; 18634643; VBIYerPse15693_3255.
DR   eggNOG; COG0277; -.
DR   HOGENOM; HOG000122232; -.
DR   KO; K03777; -.
DR   OMA; MHRDIFD; -.
DR   OrthoDB; EOG6Z3KJX; -.
DR   BioCyc; YPSE349747:GH71-2868-MONOMER; -.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0008720; F:D-lactate dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0008762; F:UDP-N-acetylmuramate dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006089; P:lactate metabolic process; IEA:InterPro.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   Gene3D; 3.30.1370.20; -; 1.
DR   Gene3D; 3.30.43.10; -; 1.
DR   Gene3D; 3.30.465.10; -; 1.
DR   Gene3D; 3.30.70.610; -; 2.
DR   InterPro; IPR016169; CO_DH_flavot_FAD-bd_sub2.
DR   InterPro; IPR016172; D-lactate_DH_C-sub1.
DR   InterPro; IPR016173; D-lactate_DH_C-sub2.
DR   InterPro; IPR012256; D_lactate_DH.
DR   InterPro; IPR016166; FAD-bd_2.
DR   InterPro; IPR016167; FAD-bd_2_sub1.
DR   InterPro; IPR016164; FAD-linked_Oxase-like_C.
DR   InterPro; IPR015409; Lactate_DH_C.
DR   InterPro; IPR006094; Oxid_FAD_bind_N.
DR   Pfam; PF01565; FAD_binding_4; 1.
DR   Pfam; PF09330; Lact-deh-memb; 1.
DR   PIRSF; PIRSF000101; D-lactate_dh; 1.
DR   SUPFAM; SSF55103; SSF55103; 1.
DR   SUPFAM; SSF56176; SSF56176; 1.
DR   PROSITE; PS51387; FAD_PCMH; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002412};
KW   FAD {ECO:0000256|PIRNR:PIRNR000101};
KW   Flavoprotein {ECO:0000256|PIRNR:PIRNR000101};
KW   NAD {ECO:0000256|PIRNR:PIRNR000101};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR000101,
KW   ECO:0000313|EMBL:ABS49402.1}.
SQ   SEQUENCE   570 AA;  64087 MW;  FA9251643C6D5607 CRC64;
     MSQFNNEKIQ LLLTQLQHIV GTRYLLTGER QTERYRTGFR SGKGVALAVV FPSTLLQQWQ
     LLQACVAADT IIIMQAANTG LTEGSTPSGD DYDRPIVILN TLRLNNIQLL DDGKQVIGFP
     GSTLNQLEKR LKPYGREPHS VIGSSCIGAS VVGGICNNSG GSLVQRGPAY TEMALYAQID
     AQGELQLINH LGISLGNTPE EILQRLEQGQ YGAEDIEQTG QQTSDSEYAT RVRDIDATTP
     SRFNADPRRL FEASGCAGKL AIFAVRLDTF PSEKQQQVFY IGTNQTQVLT ELRRIILRDF
     KHLPIAGEYL HRDIFDIAET YGKDTFVMIN SMGTNNMPRF FTLKGKIDAR LNKILHLVDH
     LTDRVMQGFS QILPNHLPKR LKTYRNQYEH HLLLKMSGDG ITEAQQHLRA FFATAEGNFI
     ACTADEGKKA FLHRFAAAGA AVRYHAVHAD QVEDILALDI ALRRNEKQWF ETLPPEIEKC
     LIAKLYYGHF LCHVFHQDYI VKKGVDVKAL KEKMLSLLND KGAEYPAEHN VGHLYLAKPA
     LKDFYQQIDP TNSFNPGIGK TSKRKRWQQD
//
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