ID A7IJ33_XANP2 Unreviewed; 3208 AA.
AC A7IJ33;
DT 11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT 11-SEP-2007, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE SubName: Full=Amino acid adenylation domain {ECO:0000313|EMBL:ABS68026.1};
GN OrderedLocusNames=Xaut_2786 {ECO:0000313|EMBL:ABS68026.1};
OS Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Xanthobacteraceae; Xanthobacter.
OX NCBI_TaxID=78245 {ECO:0000313|EMBL:ABS68026.1, ECO:0000313|Proteomes:UP000002417};
RN [1] {ECO:0000313|EMBL:ABS68026.1, ECO:0000313|Proteomes:UP000002417}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1158 / Py2 {ECO:0000313|Proteomes:UP000002417};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N.,
RA Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D.,
RA Detter J.C., Han C., Tapia R., Brainard J., Schmutz J., Larimer F.,
RA Land M., Hauser L., Kyrpides N., Kim E., Ensigns S.A., Richardson P.;
RT "Complete sequence of chromosome of Xanthobacter autotrophicus Py2.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CP000781; ABS68026.1; -; Genomic_DNA.
DR STRING; 78245.Xaut_2786; -.
DR KEGG; xau:Xaut_2786; -.
DR eggNOG; COG0318; Bacteria.
DR eggNOG; COG1020; Bacteria.
DR HOGENOM; CLU_000022_11_0_5; -.
DR PhylomeDB; A7IJ33; -.
DR Proteomes; UP000002417; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:InterPro.
DR CDD; cd17643; A_NRPS_Cytc1-like; 1.
DR CDD; cd05931; FAAL; 1.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 3.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 3.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR040097; FAAL/FAAC.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 3.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 4.
DR Pfam; PF00550; PP-binding; 3.
DR SMART; SM00823; PKS_PP; 3.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 6.
DR PROSITE; PS00455; AMP_BINDING; 3.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002417}.
FT DOMAIN 597..671
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1646..1721
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3101..3176
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 3208 AA; 339770 MW; DCBE93C343E60E46 CRC64;
MNRLPQPPML LASAVPSADM ATHLADLAIR QGEALALHLL DDPRDGEREV SYAALDARAR
AFAARLADHA EPGARVLLLL ETGLDYVGAF FGCLYAGLIA VPAFPPEANR PQHQARLAAM
ARDCGAAIAL VHAGDRAAAE SLLAAQTGTA VLSVEEVADG DGDGFALRRP RPSDIAFLQY
TSGSTSTPKG VMVSHGNLIA NEIAIRAGFS IQPDKTILSW LPLYHDMGLI GGLLQPLFNG
AACILMSPRH FLARPVRWLE ALSRFRSEVS GGPDFAYRMC VERIDPAQVQ GLDLSSWKVA
YSGSEPVRAS TMEAFAARFA PLGFDARAVH PCYGLAEATL FVTAQRRGDG LKAPGFDATR
LAEGEAQPGQ DPEAVRVVAC GAPADDHGMR ILDPATGAPV PEGRVGEVVA FGPSIAQGYW
NNPAATAATF PEIEGVRALR TGDLGFLSGG QLYLAGRAKD LIIIRGQNLY PHDIEEVIER
EVDLVRQGRI AAFPVACDDG EGIGVAVEIS RRTRKTVSAQ SIAALVAEVV GDAFLEPARV
VVLLEPGALP RTSSGKLQRS AVARGYQDGT LDAFAILRDG VLEDRTGEIA PMTPVAPALS
AMADKLAAIW SEVLGRQDLT ADSHFFALGG NSVEAMRVRA RLAALGLDVP VAELFRHPTL
GRLAAALEQI GAAKPDFVAP VTTPDGPAPL TPAQRRMWFL CEVAAGAASR SAYHVAGGIR
FEAPVDRDAL AAALQDLVAR HGALRTRFLR MEDGDAVQEE LAAADLPLAD ADLGDDTDGA
HYAALAKTHA EAPFDLGAAP LARALLVRRP DGRDELLVTL HHLICDGWSL ALLSEELAAA
YTARAAGSAP ALPPAGSYLA YAHRQATEAP DQAGLAFWCD RLTNAPALTT LPADHPRPAE
ASHRGGRLDI TFDPALTADL RALAAAADAT LPMALLALFN VLLHRLSGAD DLTVGLAFAN
RAAADSHVTM GLFVNTLPLR LEVDGAAAFA EVLRRVRDGV MEAQTHQHVP LDRVLDALGT
ARSLSRHPLF QTLYTHLPRR ARAGVDTFTR DSGGQQFDLA LETAETADGG LALAFGYALD
LFEPATVARF ADAFATLARA AVAAPDTRLD LLALVDEAAL AARAAPWPDD SPLPDLPVPD
LIALQARLRP DAPAVIFGEQ VTSFAALEGE ANRLAHVLVA HGVGPEARVG VGLPRGPGLI
AALLAVWKAG GAFVPFDPDH PAERIAHILA DAGTTLVLAR EGVTPGVPVL DPDQIDLSSQ
PATPVSRTAH SEQLAYLVYT SGSTGRPKGV MVAHGALAMH CRATGALYET SERTREFHFL
SMSFDGAHER WMVPLIHGGA IILTDRTPWA MADTLDTLAR HRATHGGFPP AYLDALAQTA
QARGEAPPVD ILSFGGEAMP AESFARAASA LKPRLLINGY GPTEAVISPL AWKVPATTRL
DTPHAPIGRA VGVRRAYVLD GALNALPVGV PGELYVAGEG LARGYQAMPG ATAERFLPDP
FGPPGGRMYR TGDRAHWRAD GTVEYLGRTD RQIKLRGFRI EPGEVEAALR GLPGVGAAAV
ALKTVGASAQ LVGYVVVAAD AAPDAAALRE ALPSTLREAL GRRLPDHMVP ARLVVLQALP
LTPNGKVDYA ALPVPERPAP TTESRPPQTE EEQMLARIWA EVLRLPNGPD LDANFFELGG
DSILSLQIVA RARRAGLVLS ARDLFEHQTI ARLAGAARRE ETPAAPEAPH GALPLTPLQR
AFLDSGAPRL QHFNQSLVLS PTRPLDASHL AAAVDHVTRQ HGALHLRFTR GADGWRQEEA
DAATTPPLAM VAAADREAAG ALFASLESAL DLAAGPLFRA MLANLDDGTQ RLFLTAHHLV
VDAVSWRILL EEIESTYLDL EQGRPVAAPA PGTPFAVRTT HLPAATVPVP AIPLPCDHPE
GANTFGHRRV TRLALHAPQV EALRQVALAH HARLDDLLLA AVVRATGRLR GLPQLTVGIE
GHGRDLVPGA DFSRTAGWFT TLAPAAVPLE DDLRRALLAT KEAARRAVPD AQAPAPALIL
NHLGRVDAGR AGALFTLDAM DLSADPGQLL GAELIVDASE SEAGAELRLT TSAARWEDAT
LARLSEAIAA DLARLAALDS DGASPSDFPL AGLSQPALDR LALPWREIED LYPLTPTQQG
ILFHVLEGSG DGAYVNQLSV TITGLDAERF AAAWVRAVAR HAILRSAFLW TADLGAPLQA
VRRHVPFAVD RHAPMDAADT SALDAIAQDD RARGFALDAA PLMRIRLVPL GADGHHFIWT
AHHLLLDGWS SARLMAEVLA DYAGAAVPPP PARFRDHVAA LAAPRADGEA FWRPRLARLE
EPSLLASATR APSVHRHLTV PLAAERWDRL GTAAKAQRVT LASLFQAAWA LALKHMTGRA
AVAFGTTVSG RPDDDPRMES VLGLFIATVP TILTVPGSGR VADFVRAVQA ESVATSAHAD
TPLVDILRWA GRSGQALFDS LLVFENYPME AGLKARVVEG LAFGPVISQE ATNFPLTLSV
ITDAEPRLAW SYDAAHVSSA TVDQLCERLL LALDLLAGHP EADLSALSLS LPQEIAAVRA
HGIAATHVAD FTPVHERIAA QARLRPDAIA VTWGADALTY ADLDRHAERI ARRLAEAGAG
PGDIVGISAE RSPALIAGLL AILKTGAAYL PLDPIYPQAR RAYMIGDAGV RCILADTANS
ADLPQTGLRH IPLDLYGEAE EDAAAMRLWP SPHPDQPAYV IYTSGSTGAP KGVVVTHGNV
ARLFTATAPW FGFGPDDVWT LFHAYGFDFS VWEIFGALSF GGRLVVVPHE VSRAPEEFLD
LVVRERVTVL NQTPSAFRPF LQVALARTET PDLALRHVIF GGEALDVGVL GPWYARFGIK
ARLVNMYGIT ETTVHVTYRP LGPGDVLGSS RSPIGGPIPD LTLHLLDDML DPVPVGVPGE
LCVGGAGLAA GYLKRPGLTA ARFVPDPYGP PGSRLYLSGD KAVRRPDGTL DYLGRGDGQV
KIRGFRIELG EIEARLRDDA TVTDAAVVVR ELPGGPALVA YVVATGTVDP TAVRERLQAG
LPDYMVPAHV VALDALPLTA NGKLDRAALP EPRATATSSA PPEGADEEAL AAIWRDVLGA
GAIGREDNFF ALGGHSLSAT QVRLEIRDRL GVEVPVRRLF ECQTLRSLAQ VLAETRATET
RATGAAPRPA LGADALAQMD ALLGELEG
//
