ID A7INF2_XANP2 Unreviewed; 217 AA.
AC A7INF2;
DT 11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT 11-SEP-2007, sequence version 1.
DT 01-MAY-2013, entry version 35.
DE RecName: Full=Thymidylate kinase;
DE EC=2.7.4.9;
DE AltName: Full=dTMP kinase;
GN Name=tmk; OrderedLocusNames=Xaut_4325;
OS Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC Xanthobacteraceae; Xanthobacter.
OX NCBI_TaxID=78245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1158 / Py2;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T.,
RA Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D.,
RA Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Brainard J.,
RA Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E.,
RA Ensigns S.A., Richardson P.;
RT "Complete sequence of chromosome of Xanthobacter autotrophicus Py2.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Phosphorylation of dTMP to form dTDP in both de novo and
CC salvage pathways of dTTP synthesis (By similarity).
CC -!- CATALYTIC ACTIVITY: ATP + dTMP = ADP + dTDP.
CC -!- SIMILARITY: Belongs to the thymidylate kinase family.
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DR EMBL; CP000781; ABS69546.1; -; Genomic_DNA.
DR RefSeq; YP_001419203.1; NC_009720.1.
DR ProteinModelPortal; A7INF2; -.
DR STRING; 78245.Xaut_4325; -.
DR EnsemblBacteria; ABS69546; ABS69546; Xaut_4325.
DR GeneID; 5424006; -.
DR KEGG; xau:Xaut_4325; -.
DR PATRIC; 24050842; VBIXanAut29526_4678.
DR eggNOG; COG0125; -.
DR HOGENOM; HOG000229078; -.
DR KO; K00943; -.
DR OMA; ITLEGPE; -.
DR ProtClustDB; CLSK980248; -.
DR GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR GO; GO:0004798; F:thymidylate kinase activity; IEA:HAMAP.
DR GO; GO:0006233; P:dTDP biosynthetic process; IEA:InterPro.
DR GO; GO:0006235; P:dTTP biosynthetic process; IEA:HAMAP.
DR HAMAP; MF_00165; Thymidylate_kinase; 1; -.
DR InterPro; IPR018095; Thymidylate_kin_CS.
DR InterPro; IPR018094; Thymidylate_kinase.
DR PANTHER; PTHR10344; PTHR10344; 1.
DR TIGRFAMs; TIGR00041; DTMP_kinase; 1.
DR PROSITE; PS01331; THYMIDYLATE_KINASE; 1.
PE 3: Inferred from homology;
KW ATP-binding; Complete proteome; Kinase; Nucleotide biosynthesis;
KW Nucleotide-binding; Transferase.
FT NP_BIND 11 18 ATP (By similarity).
SQ SEQUENCE 217 AA; 22259 MW; 72CE581D750447A6 CRC64;
MTQGRFITLE GGEGTGKSTQ ARRLAAHLRT LGHTVVETRE PGGSPGAEAV RHVLLSGAAE
PLGPVAEALL FAAARTDHVQ TLIRPALAAG TIVICDRFID STRVYQGAVG QVAPPLLDAL
EEMATGGTRP DLTLILDVPP ETGLARAAAR GNGDPDRFEK EGAAYHAAVR EAFVARAAAA
PARCVLVDAT PDPDAVAAQI AGIVAARLGL HATAEAS
//
