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Database: UniProt/TrEMBL
Entry: A7SKY7_NEMVE
LinkDB: A7SKY7_NEMVE
Original site: A7SKY7_NEMVE 
ID   A7SKY7_NEMVE            Unreviewed;      1096 AA.
AC   A7SKY7;
DT   02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   02-OCT-2007, sequence version 1.
DT   25-OCT-2017, entry version 55.
DE   RecName: Full=Angiotensin-converting enzyme {ECO:0000256|RuleBase:RU361144};
DE            EC=3.4.-.- {ECO:0000256|RuleBase:RU361144};
GN   ORFNames=v1g190941 {ECO:0000313|EMBL:EDO35659.1};
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351 {ECO:0000313|Proteomes:UP000001593};
RN   [1] {ECO:0000313|EMBL:EDO35659.1, ECO:0000313|Proteomes:UP000001593}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J.,
RA   Salamov A., Terry A., Shapiro H., Lindquist E., Kapitonov V.V.,
RA   Jurka J., Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E.,
RA   Finnerty J.R., Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU361144};
CC       Note=Binds 2 Zn(2+) ions per subunit.
CC       {ECO:0000256|RuleBase:RU361144};
CC   -!- SIMILARITY: Belongs to the peptidase M2 family.
CC       {ECO:0000256|RuleBase:RU361144}.
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DR   EMBL; DS469692; EDO35659.1; -; Genomic_DNA.
DR   RefSeq; XP_001627759.1; XM_001627709.1.
DR   UniGene; Nve.17989; -.
DR   ProteinModelPortal; A7SKY7; -.
DR   STRING; 45351.NEMVEDRAFT_v1g190941-PA; -.
DR   EnsemblMetazoa; EDO35659; EDO35659; NEMVEDRAFT_v1g190941.
DR   GeneID; 5507095; -.
DR   KEGG; nve:NEMVE_v1g190941; -.
DR   eggNOG; KOG3690; Eukaryota.
DR   eggNOG; ENOG410XPJ3; LUCA.
DR   HOGENOM; HOG000007838; -.
DR   InParanoid; A7SKY7; -.
DR   KO; K01283; -.
DR   OMA; VTMEQLF; -.
DR   OrthoDB; EOG091G033S; -.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008241; F:peptidyl-dipeptidase activity; IEA:InterPro.
DR   CDD; cd06461; M2_ACE; 2.
DR   InterPro; IPR001548; Peptidase_M2.
DR   PANTHER; PTHR10514; PTHR10514; 2.
DR   Pfam; PF01401; Peptidase_M2; 2.
DR   PRINTS; PR00791; PEPDIPTASEA.
PE   3: Inferred from homology;
KW   Carboxypeptidase {ECO:0000256|RuleBase:RU361144};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001593};
KW   Glycoprotein {ECO:0000256|RuleBase:RU361144};
KW   Hydrolase {ECO:0000256|RuleBase:RU361144};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|RuleBase:RU361144};
KW   Metalloprotease {ECO:0000256|RuleBase:RU361144};
KW   Protease {ECO:0000256|RuleBase:RU361144};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Zinc {ECO:0000256|RuleBase:RU361144}.
FT   TRANSMEM   1076   1095       Helical. {ECO:0000256|SAM:Phobius}.
SQ   SEQUENCE   1096 AA;  126380 MW;  A9C025507286AF2A CRC64;
     MQYSQRESEM TEIYSSAKVT NPAIGTNLSL NPQLTELMAN SRNSPELLAA WRDWRQVTGP
     KMRPLFKDCV TLANQGAKDN GFQNMYEYQT HLYELPNLEE YIDGIWQELK VLYLELHAYV
     RQRLSEQYPH VLSSQAIPAH LLGNMWAQNW VNIYPLVEPY SGKPSLDVTK NLRQQNYTAV
     KMVQLAEAFF RSIGFEKLPG SFYSKSMFEK PEDREVLCHA AALDFFEKNS KGEKDVRIKQ
     CTEITHQDLI ITHHEMGHIY YFLKYWDQPY IYRDGANPAF HEALGDTIAL SVDTPRHLVK
     VKLLDEYMED KEAEINALMK MALSKIAFLP FGYLLEKWRW QVYTGEIDSS EYNKKWWELR
     VKHQGVRPPI SRDETTFDPG SKFHIAANAR YIQYFLSRIL QFQLHKTVCD IAGINEPLHK
     CSIYNSTKAG QKLSAMLEMG RSKPWRDTLE AFTGSRDMSV NPLKEYFHPL YQWLVEQRCQ
     NKYKIGWPGT EGPDYDPCEP PTFLPPVEPT SSHHTALPSA HASKTAGLST HVILGICFMA
     SSFLEEARKE AKKFDLTKLS NDTRRQIKMV TETASSSDKD VQKTLNDVEG KMDQIYGSGK
     VIDTDGSKLS LDPHLYKILS NSRDYERLKF VWKGWRDATG PELRPLYKQF VELANKGAKE
     NGWADNGEWW RSWYEIDNLE SSVEALYEDL RPLYEELHAY VRYKLSKKYS QVKPTGPIPA
     HVFGNMWAQS WVNIYDIIEP YENQPSLDVT KTMVAQNYTQ LRMVQLAESF FTSIGLKALP
     MSFYEKSMIV KPEGREVQCH ASAWDFKINR DVRIKQCTTI THNYLVTTHH ELGHIQYYLQ
     YWDQPFEYRT GANPGFHEAV GDTLSLSVDT PTHLKLIGLL DAVSNDSKSD INALMKMALR
     KVAFLPFGFL IDQWRWKVFS GDITSDNYNR EWWKLRTKYQ GIKPPVCRTE NDFDPGAKYH
     IPGNTPYIRY FVSFVLQFQF HKAACEAAGH QGPLHKCSIY NSTEAGKKLG DMLSLGKSKP
     WPLALEQMTG TRKMDVSSLK EYFKPLSDWL KSQRQEYKYT IGWSNDGAYD ECPSSAGAML
     VPFIGSILAA LLIALY
//
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