ID   A7UXI1_NEUCR            Unreviewed;       613 AA.
AC   A7UXI1;
DT   23-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   23-OCT-2007, sequence version 1.
DT   27-SEP-2017, entry version 43.
DE   SubName: Full=Carotenoid oxygenase 2 {ECO:0000313|EMBL:EDO64867.1};
GN   Name=cao-2 {ECO:0000313|EMBL:EDO64867.1};
GN   ORFNames=NCU11424 {ECO:0000313|EMBL:EDO64867.1};
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM
OS   1257 / FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Sordariomycetidae; Sordariales; Sordariaceae;
OC   Neurospora.
OX   NCBI_TaxID=367110 {ECO:0000313|EMBL:EDO64867.1, ECO:0000313|Proteomes:UP000001805};
RN   [1] {ECO:0000313|EMBL:EDO64867.1, ECO:0000313|Proteomes:UP000001805}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC   {ECO:0000313|Proteomes:UP000001805};
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D., FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A.,
RA   Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L.,
RA   Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes W., Staben C.,
RA   Marcotte E., Greenberg D., Roy A., Foley K., Naylor J.,
RA   Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M.,
RA   Mauceli E., Bielke C., Rudd S., Frishman D., Krystofova S.,
RA   Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C.,
RA   Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M.,
RA   Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000256|SAAS:SAAS00853222};
CC   -!- SIMILARITY: Belongs to the carotenoid oxygenase family.
CC       {ECO:0000256|SAAS:SAAS00853223}.
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DR   EMBL; CM002242; EDO64867.1; -; Genomic_DNA.
DR   RefSeq; XP_001727958.1; XM_001727906.2.
DR   EnsemblFungi; EDO64867; EDO64867; NCU11424.
DR   GeneID; 5846978; -.
DR   KEGG; ncr:NCU11424; -.
DR   EuPathDB; FungiDB:NCU11424; -.
DR   HOGENOM; HOG000166169; -.
DR   InParanoid; A7UXI1; -.
DR   KO; K17842; -.
DR   OMA; SMISIYP; -.
DR   OrthoDB; EOG092C2DBB; -.
DR   Proteomes; UP000001805; Chromosome 7, Linkage Group VII.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:InterPro.
DR   InterPro; IPR004294; Carotenoid_Oase.
DR   PANTHER; PTHR10543; PTHR10543; 1.
DR   Pfam; PF03055; RPE65; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001805};
KW   Iron {ECO:0000256|SAAS:SAAS00853218};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00853220};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001805}.
SQ   SEQUENCE   613 AA;  68478 MW;  2D6C822DC356DA85 CRC64;
     MSPHEVIGTV PKNSTTFRTQ ADEHDDHEEA LQNLRTGKYE DWPNEAAFDG LTEERGPIKI
     AVTGNIPTWA AGSLYRTGPG LYKIDTDAGT TFEMSHWFDG LAHTHRFDII PNEEGSVDIF
     YSSRRQAEEM MDVIKKQGTW PYYSFGQKAD PCLGFFAKAM AAFKGLREPS GEKWHNNVNV
     AVHVNPPGLE AVRNIVGTRK PAVAENDANV LGHRPELPKS IWVSTDNSTM KQIDPQTLEP
     IGWATQDVLH PELTGAMSCA HAQRDPDTGD FFNFNLEFGP KPTYRVFRVD ASSGKTEILA
     TIREPSVSPA YIHSLFLSPS FVILCIPTSH FGLSGTQIPW ERNLVDAIKP YDPSRKTQWI
     VIDRKHSKGV VARFETDGRF FFHTVNSFEE KAGSDSSDIN LYCDVIDFGS HEFIHSLYLD
     VILNRDSAAK KFYEDEQRAR NSLAHLTRYH FIINPDSPTT NLPVTPTPDP KNHEAFRIPA
     PHAGEIPTIN PLYATRKHRY VYSLPFRGRG TITDAIVKTD TVTREALFWD NPKGHTPGEA
     IFIPRPGGEE EDDGVLLSLV LDGEKGKSYL LCLDAKTMAE MGRAEVDFAI ALGFHGAHVP
     SGRTLTRVEG PEY
//