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Database: UniProt/TrEMBL
Entry: A8EVB3_ARCB4
LinkDB: A8EVB3_ARCB4
Original site: A8EVB3_ARCB4 
ID   A8EVB3_ARCB4            Unreviewed;       737 AA.
AC   A8EVB3;
DT   13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2007, sequence version 1.
DT   19-FEB-2014, entry version 52.
DE   RecName: Full=Phosphoribosylformylglycinamidine synthase 2;
DE            EC=6.3.5.3;
DE   AltName: Full=Phosphoribosylformylglycinamidine synthase II;
GN   Name=purL; OrderedLocusNames=Abu_1639;
OS   Arcobacter butzleri (strain RM4018).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Campylobacteraceae; Arcobacter.
OX   NCBI_TaxID=367737;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RM4018;
RX   PubMed=18159241; DOI=10.1371/journal.pone.0001358;
RA   Miller W.G., Parker C.T., Rubenfield M., Mendz G.L., Wosten M.M.,
RA   Ussery D.W., Stolz J.F., Binnewies T.T., Hallin P.F., Wang G.,
RA   Malek J.A., Rogosin A., Stanker L.H., Mandrell R.E.;
RT   "The complete genome sequence and analysis of the
RT   Epsilonproteobacterium Arcobacter butzleri.";
RL   PLoS ONE 2:E1358-E1358(2007).
CC   -!- CATALYTIC ACTIVITY: ATP + N(2)-formyl-N(1)-(5-phospho-D-
CC       ribosyl)glycinamide + L-glutamine + H(2)O = ADP + phosphate + 2-
CC       (formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate.
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-
CC       phospho-D-ribosyl)glycinamide: step 1/2.
CC   -!- SUBUNIT: Heterodimer of two subunits, PurQ and PurL (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the FGAMS family.
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DR   EMBL; CP000361; ABV67886.1; -; Genomic_DNA.
DR   RefSeq; YP_001490556.1; NC_009850.1.
DR   ProteinModelPortal; A8EVB3; -.
DR   STRING; 367737.Abu_1639; -.
DR   EnsemblBacteria; ABV67886; ABV67886; Abu_1639.
DR   GeneID; 5623498; -.
DR   KEGG; abu:Abu_1639; -.
DR   PATRIC; 20964640; VBIArcBut20197_1611.
DR   eggNOG; COG0046; -.
DR   HOGENOM; HOG000238227; -.
DR   KO; K01952; -.
DR   OMA; SQERMLF; -.
DR   OrthoDB; EOG6FNHHR; -.
DR   ProtClustDB; PRK01213; -.
DR   BioCyc; ABUT367737:GHWO-1637-MONOMER; -.
DR   UniPathway; UPA00074; UER00128.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0004642; F:phosphoribosylformylglycinamidine synthase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   HAMAP; MF_00420; PurL_2; 1.
DR   InterPro; IPR010918; AIR_synth_C_dom.
DR   InterPro; IPR000728; AIR_synth_N_dom.
DR   InterPro; IPR010074; PRibForGlyAmidine_synth_II.
DR   InterPro; IPR016188; PurM_N-like.
DR   Pfam; PF00586; AIRS; 2.
DR   Pfam; PF02769; AIRS_C; 2.
DR   SUPFAM; SSF55326; SSF55326; 2.
DR   SUPFAM; SSF56042; SSF56042; 2.
DR   TIGRFAMs; TIGR01736; FGAM_synth_II; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; Ligase; Nucleotide-binding;
KW   Purine biosynthesis.
FT   NP_BIND     105    116       ATP (By similarity).
SQ   SEQUENCE   737 AA;  79761 MW;  36D88E431F0585B9 CRC64;
     MQKKEMNIQE IALAHSLTLE EFENIKEILG REPNYVEIGI FSAMWSEHCS YKSSKKYLSG
     FPTKAPWVIQ GPGENAGVID IGDGYAAVFK MESHNHPSFI EPYQGAATGV GGILRDVFTM
     GARPIANMNS IRFASIEGDS ETAQKHRYLL KGVVAGIGGY GNCMGVPTIG GETTFEECYA
     GNNLVNAFTL GLAKADEIFY GKAEGIGNPV MYVGSKTGRD GLGGAVMSSA AFDEDSESKR
     PTVQVGDPFT EKLLLEACLE LFKADLIVGI QDMGAAGLTS SSFEMAGRSG SGMIMHLDKV
     PAREEGMTPY DFMLSESQER MLICAKKGCE QAIIDIFQKW ELDVAVIGEV TATGNMELFW
     HGEKVAEVPV QPVSEQAPIL DRPVKKPAYL DGIENISLDK ELSNQVVFDE LFSDMEVVDK
     SWVYSQYDSM VQTNTIKGPG SLDGSSIRIK ETGKALSMSA DCNTRFCYIN PELGAAAAVM
     ESGRNVAMTG AVPKAITDCL NFGNPTNPEV MWQFKECCEG IKKACKDLNT PVIGGNVSLY
     NETNGVGVFP TPSIAMVGVN DDANKVLPSK LQENGNILYL LGETKSEFGG SLYLKKLYGK
     VAGVHPEVSF EKELALWNTV IEANKLGLLK AAKDVNVGGI AIALAKMAVV GNKGIEVNIS
     LNDSKDIFSE SLSRAIVEVN PSNCEAFEKI AKSFGLECTK IGVVKGNKIS INDIYKDLDK
     VSDVYFNRFK QVIEQVS
//
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