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Database: UniProt/TrEMBL
Entry: A8F8Y5_BACP2
LinkDB: A8F8Y5_BACP2
Original site: A8F8Y5_BACP2 
ID   A8F8Y5_BACP2            Unreviewed;       378 AA.
AC   A8F8Y5;
DT   13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 2.
DT   02-NOV-2016, entry version 64.
DE   RecName: Full=DNA polymerase III subunit beta {ECO:0000256|PIRNR:PIRNR000804, ECO:0000256|SAAS:SAAS00018186};
DE            EC=2.7.7.7 {ECO:0000256|PIRNR:PIRNR000804, ECO:0000256|SAAS:SAAS00018259};
GN   OrderedLocusNames=BPUM_0002 {ECO:0000313|EMBL:ABV60702.2};
OS   Bacillus pumilus (strain SAFR-032).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=315750 {ECO:0000313|EMBL:ABV60702.2, ECO:0000313|Proteomes:UP000001355};
RN   [1] {ECO:0000313|EMBL:ABV60702.2, ECO:0000313|Proteomes:UP000001355}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SAFR-032 {ECO:0000313|EMBL:ABV60702.2,
RC   ECO:0000313|Proteomes:UP000001355};
RX   PubMed=17895969; DOI=10.1371/journal.pone.0000928;
RA   Gioia J., Yerrapragada S., Qin X., Jiang H., Igboeli O.C., Muzny D.,
RA   Dugan-Rocha S., Ding Y., Hawes A., Liu W., Perez L., Kovar C.,
RA   Dinh H., Lee S., Nazareth L., Blyth P., Holder M., Buhay C.,
RA   Tirumalai M.R., Liu Y., Dasgupta I., Bokhetache L., Fujita M.,
RA   Karouia F., Eswara Moorthy P., Siefert J., Uzman A., Buzumbo P.,
RA   Verma A., Zwiya H., McWilliams B.D., Olowu A., Clinkenbeard K.D.,
RA   Newcombe D., Golebiewski L., Petrosino J.F., Nicholson W.L., Fox G.E.,
RA   Venkateswaran K., Highlander S.K., Weinstock G.M.;
RT   "Paradoxical DNA repair and peroxide resistance gene conservation in
RT   Bacillus pumilus SAFR-032.";
RL   PLoS ONE 2:E928-E928(2007).
CC   -!- FUNCTION: DNA polymerase III is a complex, multichain enzyme
CC       responsible for most of the replicative synthesis in bacteria.
CC       This DNA polymerase also exhibits 3' to 5' exonuclease activity.
CC       The beta chain is required for initiation of replication once it
CC       is clamped onto DNA, it slides freely (bidirectional and ATP-
CC       independent) along duplex DNA. {ECO:0000256|PIRNR:PIRNR000804}.
CC   -!- CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) =
CC       diphosphate + DNA(n+1). {ECO:0000256|PIRNR:PIRNR000804,
CC       ECO:0000256|SAAS:SAAS00018252}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR000804,
CC       ECO:0000256|SAAS:SAAS00346815}.
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DR   EMBL; CP000813; ABV60702.2; -; Genomic_DNA.
DR   RefSeq; WP_041815072.1; NC_009848.4.
DR   ProteinModelPortal; A8F8Y5; -.
DR   STRING; 315750.BPUM_0002; -.
DR   KEGG; bpu:BPUM_0002; -.
DR   PATRIC; 18963703; VBIBacPum16546_0002.
DR   eggNOG; ENOG4105CZ8; Bacteria.
DR   eggNOG; COG0592; LUCA.
DR   HOGENOM; HOG000071792; -.
DR   KO; K02338; -.
DR   OrthoDB; POG091H02B3; -.
DR   Proteomes; UP000001355; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009360; C:DNA polymerase III complex; IEA:InterPro.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd00140; beta_clamp; 1.
DR   InterPro; IPR001001; DNA_polIII_beta.
DR   InterPro; IPR022635; DNA_polIII_beta_C.
DR   InterPro; IPR022637; DNA_polIII_beta_cen.
DR   InterPro; IPR022634; DNA_polIII_beta_N.
DR   Pfam; PF00712; DNA_pol3_beta; 1.
DR   Pfam; PF02767; DNA_pol3_beta_2; 1.
DR   Pfam; PF02768; DNA_pol3_beta_3; 1.
DR   PIRSF; PIRSF000804; DNA_pol_III_b; 1.
DR   SMART; SM00480; POL3Bc; 1.
DR   TIGRFAMs; TIGR00663; dnan; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001355};
KW   Cytoplasm {ECO:0000256|PIRNR:PIRNR000804,
KW   ECO:0000256|SAAS:SAAS00425025};
KW   DNA replication {ECO:0000256|PIRNR:PIRNR000804,
KW   ECO:0000256|SAAS:SAAS00425008};
KW   DNA-directed DNA polymerase {ECO:0000256|PIRNR:PIRNR000804,
KW   ECO:0000256|SAAS:SAAS00425005};
KW   Nucleotidyltransferase {ECO:0000256|PIRNR:PIRNR000804,
KW   ECO:0000256|SAAS:SAAS00425030};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001355};
KW   Transferase {ECO:0000256|PIRNR:PIRNR000804,
KW   ECO:0000256|SAAS:SAAS00425021}.
FT   DOMAIN        1    127       DNA_pol3_beta. {ECO:0000259|Pfam:
FT                                PF00712}.
FT   DOMAIN      136    251       DNA_pol3_beta_2. {ECO:0000259|Pfam:
FT                                PF02767}.
FT   DOMAIN      254    376       DNA_pol3_beta_3. {ECO:0000259|Pfam:
FT                                PF02768}.
SQ   SEQUENCE   378 AA;  42022 MW;  06EF05DB899FA59C CRC64;
     MKFTIQKDRL VESVQDVLKA VSSRTTIPIL TGIKIVASDE GVSLTGSDSD ISIESFIPQR
     DGDLEVITID RPGSIVLQAR FFSEIVKKLP MATVEIEVEQ NHLTIIRSGS AEFNLNGLDA
     EEYPHLPQIE EHHAFQIPTD LLKNLIRQTV FAVSTSETRP ILTGVNWKVE KGELICTATD
     SHRLALRKAK LDIDEESSYN VVIPGKSLTE LSRILDDGQD LVSIVITETQ VLFKAQNVLF
     FSRLLDGNYP DTARLIPQES KTDVVVNTKE FLQAIDRASL LAREGRNNVV KLSADPEQSL
     EISSNSPEIG KVVETVQADD IKGEDLKISF SPKYMLDALK VLEGTEIHVS FTGAMRPFLL
     RTPNDDSILQ LILPVRTY
//
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