ID A8WH42_XENLA Unreviewed; 607 AA.
AC A8WH42;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 24-JAN-2024, entry version 73.
DE SubName: Full=LOC100127248 protein {ECO:0000313|EMBL:AAI54966.1};
DE SubName: Full=Lactase, gene 1 L homeolog {ECO:0000313|RefSeq:NP_001106299.1};
GN Name=lct.1.L {ECO:0000313|RefSeq:NP_001106299.1,
GN ECO:0000313|Xenbase:XB-GENE-5930998};
GN Synonyms=lac {ECO:0000313|RefSeq:NP_001106299.1}, lct
GN {ECO:0000313|RefSeq:NP_001106299.1,
GN ECO:0000313|Xenbase:XB-GENE-5930998}, lct.1
GN {ECO:0000313|RefSeq:NP_001106299.1,
GN ECO:0000313|Xenbase:XB-GENE-5930998}, lct.1.S
GN {ECO:0000313|RefSeq:NP_001106299.1}, LOC100127248
GN {ECO:0000313|EMBL:AAI54966.1}, lph
GN {ECO:0000313|RefSeq:NP_001106299.1}, lph1
GN {ECO:0000313|RefSeq:NP_001106299.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAI54966.1};
RN [1] {ECO:0000313|RefSeq:NP_001106299.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAI54966.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Intestine {ECO:0000313|EMBL:AAI54966.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001106299.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 1 family.
CC {ECO:0000256|RuleBase:RU003690}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC154965; AAI54966.1; -; mRNA.
DR RefSeq; NP_001106299.1; NM_001112828.1.
DR CAZy; GH1; Glycoside Hydrolase Family 1.
DR DNASU; 100127248; -.
DR GeneID; 100127248; -.
DR KEGG; xla:100127248; -.
DR CTD; 100127248; -.
DR Xenbase; XB-GENE-5930998; lct.1.L.
DR OrthoDB; 3373839at2759; -.
DR Proteomes; UP000186698; Chromosome 9_10L.
DR Bgee; 100127248; Expressed in intestine and 2 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.80; Glycosidases; 2.
DR InterPro; IPR001360; Glyco_hydro_1.
DR InterPro; IPR018120; Glyco_hydro_1_AS.
DR InterPro; IPR033132; Glyco_hydro_1_N_CS.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR10353; GLYCOSYL HYDROLASE; 1.
DR PANTHER; PTHR10353:SF38; LACTASE-PHLORIZIN HYDROLASE; 1.
DR Pfam; PF00232; Glyco_hydro_1; 2.
DR PRINTS; PR00131; GLHYDRLASE1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 2.
DR PROSITE; PS00572; GLYCOSYL_HYDROL_F1_1; 1.
DR PROSITE; PS00653; GLYCOSYL_HYDROL_F1_2; 1.
PE 2: Evidence at transcript level;
KW Glycosidase {ECO:0000256|RuleBase:RU004468};
KW Hydrolase {ECO:0000256|RuleBase:RU004468};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 572..595
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 527..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..553
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 431
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10055"
SQ SEQUENCE 607 AA; 69253 MW; 764DCC64C42E3815 CRC64;
MDTFEWNSGY SVRFGLHHVD FKNPSRPRTP KRSAIYYAEI IRNKGMPLSK EDEFLYGEFS
KDFAWSVASA SYQIEGAWRA DGKSLSIWDQ YAHTPLRIGN DDNGDIACDS YNRIEQDVTA
LKNLKVSHYR FSVSWSRILP DGTRNFVNEA GLNYYVRLID ALLVANISPQ VTLYHWDLPQ
VLQNIGGWEN DTIVEKFKDY ADLLFQKLGD KVKFWITINE PYIVANLGYG YGTAAPGISS
RPGRAPYIVG HNLIKAHAEA WHLYNDKYRA SQGGLISITI NSDWAEPRNP YKQEDVEAAR
RYMMFYGGWF ANPIFNNGDY NEVMKSRVRE RSLASGLTQS RLPEFTESEK QRIKGTFDYF
GFNHYTTILA SPFNLPISQQ TYDADRGVAS TTDHSWLGSG SFWLKVTPFG FRRILNWIKE
EYNNPPILVT ENGISERGTD LNDVWREHYY KEYINEALKA VKYDGVDLRG YTAWSLMDNF
EWATGFAERF GLHYTNYSDP ELARIPKKST KYYRSIILCN GFPDPSNGSP PCLEPETEGT
TAPTVTTPPS GENQEEAVSF LGLEISPSDA EVALYVEFAF LIAAVLGIVL LSVFYRKLAK
KPKMSNF
//