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Database: UniProt/TrEMBL
Entry: A8XKA2_CAEBR
LinkDB: A8XKA2_CAEBR
Original site: A8XKA2_CAEBR 
ID   A8XKA2_CAEBR            Unreviewed;       905 AA.
AC   A8XKA2;
DT   15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT   15-JAN-2008, sequence version 1.
DT   05-JUL-2017, entry version 66.
DE   RecName: Full=Angiotensin-converting enzyme {ECO:0000256|RuleBase:RU361144};
DE            EC=3.4.-.- {ECO:0000256|RuleBase:RU361144};
GN   Name=acn-1 {ECO:0000313|WormBase:CBG14607};
GN   Synonyms=Cbr-acn-1 {ECO:0000313|EMBL:CAP33076.1};
GN   ORFNames=CBG14607 {ECO:0000313|WormBase:CBG14607}, CBG_14607
GN   {ECO:0000313|EMBL:CAP33076.1};
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP33076.1, ECO:0000313|Proteomes:UP000008549};
RN   [1] {ECO:0000313|EMBL:CAP33076.1, ECO:0000313|Proteomes:UP000008549}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16 {ECO:0000313|EMBL:CAP33076.1,
RC   ECO:0000313|Proteomes:UP000008549};
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A.,
RA   D'Eustachio P., Fitch D.H., Fulton L.A., Fulton R.E.,
RA   Griffiths-Jones S., Harris T.W., Hillier L.W., Kamath R.,
RA   Kuwabara P.E., Mardis E.R., Marra M.A., Miner T.L., Minx P.,
RA   Mullikin J.C., Plumb R.W., Rogers J., Schein J.E., Sohrmann M.,
RA   Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K., Durbin R.,
RA   Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for
RT   comparative genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU361144};
CC       Note=Binds 1 zinc ion per subunit.
CC       {ECO:0000256|RuleBase:RU361144};
CC   -!- SIMILARITY: Belongs to the peptidase M2 family.
CC       {ECO:0000256|RuleBase:RU361144}.
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DR   EMBL; HE600983; CAP33076.1; -; Genomic_DNA.
DR   RefSeq; XP_002644637.1; XM_002644591.1.
DR   ProteinModelPortal; A8XKA2; -.
DR   STRING; 6238.CBG14607; -.
DR   EnsemblMetazoa; CBG14607; CBG14607; WBGene00035046.
DR   GeneID; 8586633; -.
DR   KEGG; cbr:CBG14607; -.
DR   CTD; 8586633; -.
DR   WormBase; CBG14607; CBP03404; WBGene00035046; Cbr-acn-1.
DR   eggNOG; KOG3690; Eukaryota.
DR   eggNOG; ENOG410XPJ3; LUCA.
DR   HOGENOM; HOG000020340; -.
DR   InParanoid; A8XKA2; -.
DR   KO; K01283; -.
DR   OMA; DFLTAHH; -.
DR   OrthoDB; EOG091G01SM; -.
DR   Proteomes; UP000008549; Chromosome X.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008241; F:peptidyl-dipeptidase activity; IEA:InterPro.
DR   GO; GO:0042395; P:ecdysis, collagen and cuticulin-based cuticle; IEA:EnsemblMetazoa.
DR   GO; GO:0045138; P:nematode male tail tip morphogenesis; IEA:EnsemblMetazoa.
DR   GO; GO:0045026; P:plasma membrane fusion; IEA:EnsemblMetazoa.
DR   InterPro; IPR001548; Peptidase_M2.
DR   PANTHER; PTHR10514; PTHR10514; 1.
DR   Pfam; PF01401; Peptidase_M2; 1.
DR   PRINTS; PR00791; PEPDIPTASEA.
PE   3: Inferred from homology;
KW   Carboxypeptidase {ECO:0000256|RuleBase:RU361144};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008549};
KW   Glycoprotein {ECO:0000256|RuleBase:RU361144};
KW   Hydrolase {ECO:0000256|RuleBase:RU361144};
KW   Metal-binding {ECO:0000256|RuleBase:RU361144};
KW   Metalloprotease {ECO:0000256|RuleBase:RU361144};
KW   Protease {ECO:0000256|RuleBase:RU361144};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008549};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Zinc {ECO:0000256|RuleBase:RU361144}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    905       Angiotensin-converting enzyme.
FT                                {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002733543.
SQ   SEQUENCE   905 AA;  100346 MW;  5D034DA1CC6EC7DD CRC64;
     MKFNILLLLL VGACLPSFSQ EIKPKSELLP GDEAPKDPEV AFAEGEPFEL TDALDTPKNG
     TVPVPEPEPK PEPEPEPEPE PSPKSEPEPE PTPEPEPAIK FDNIESEDYG DVAEAVVTQP
     DELNTEVIEQ LVDTFLNTGS IAPNKTNKGP VYANPVAQAL VNSSDYWKAD NLQAPGSIKD
     EEKLRSWLAG YEAEAIKVLR EVALSGWRYF NDASPSLKLA LDEAENVLTM FVKSTSMQAK
     QFDKASVTDE RLKRQLGYVS FEGMSALAPS RFAEFSQAQS TLNRDSKDST ICDKDVPPPC
     ALQKIDMDSI FRNEKDASRL QHLWVSYVTA IAKSKPAYNN IIAISNEGAK LNGFANGGAM
     WRSAFDTPSN MADLTKQVEK IYSTIQPFYQ LLHAYMRRQL AGIYSNPAGL SKDGPIPAHL
     FGSLDGGDWS AHYEQTKPYE EESETPEAIL AAFTSQNYTT KKMFVTAYRY FKSAGFPQLP
     KNFWTSSIFA RVWSKDMICH PAAALDMRAP NDFRVKSCAQ LGEPDFEQAH SLLVQTYYQY
     LYKDQSLLFR EPASPVITDA IASAFAYLAT NPHYLYSQKL VPSDHLDIKN SVIINKLYKE
     SLESFTKLPF TIAADNWRYE LFEGKVPKNK LNDRWWEIRN KYEGTRSPQP YNTSNLDALI
     HNSVSQVNSP ATRSLISYVL KFQILKALCP EGTILSEGCI LSEDTTEKLR ETMKLGSSIT
     WLKALEMITG KGELDAQPLL EYYEPLINWL RNTNEIDQVV IGWDGEGTPF TVEEIPKTRQ
     PGDGGNGLPS EDRVAFPGGE CVNGQECLLD SHCNGTICVC NEGLFTLEIG NTFNCVPGNP
     ADSGFGDGKG GLVIGLFNNE ATTPEPAAEP EPTTVTSTKM PPRVRSSAAL PTFLLTVLPV
     FYYLL
//
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