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Database: UniProt/TrEMBL
Entry: A8XXD3_CAEBR
LinkDB: A8XXD3_CAEBR
Original site: A8XXD3_CAEBR 
ID   A8XXD3_CAEBR            Unreviewed;       315 AA.
AC   A8XXD3;
DT   15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT   15-JAN-2008, sequence version 1.
DT   19-FEB-2014, entry version 57.
DE   RecName: Full=Thymidylate synthase;
DE            EC=2.1.1.45;
GN   ORFNames=CBG20269, CBG_20269;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A.,
RA   D'Eustachio P., Fitch D.H.A., Fulton L.A., Fulton R.E.,
RA   Griffiths-Jones S., Harris T.W., Hillier L.W., Kamath R.,
RA   Kuwabara P.E., Mardis E.R., Marra M.A., Miner T.L., Minx P.,
RA   Mullikin J.C., Plumb R.W., Rogers J., Schein J.E., Sohrmann M.,
RA   Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K., Durbin R.M.,
RA   Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for
RT   comparative genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- CATALYTIC ACTIVITY: 5,10-methylenetetrahydrofolate + dUMP =
CC       dihydrofolate + dTMP.
CC   -!- PATHWAY: Pyrimidine metabolism; dTTP biosynthesis.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data.
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DR   EMBL; HE601190; CAP37322.1; -; Genomic_DNA.
DR   RefSeq; XP_002640365.1; XM_002640319.1.
DR   ProteinModelPortal; A8XXD3; -.
DR   SMR; A8XXD3; 31-315.
DR   STRING; 6238.CBG20269; -.
DR   EnsemblMetazoa; CBG20269; CBG20269; CBG20269.
DR   GeneID; 8582360; -.
DR   KEGG; cbr:CBG20269; -.
DR   CTD; 8582360; -.
DR   WormBase; CBG20269; CBP19819; WBGene00039295; -.
DR   eggNOG; COG0207; -.
DR   HOGENOM; HOG000257899; -.
DR   KO; K00560; -.
DR   OMA; NLGPVYG; -.
DR   OrthoDB; EOG725DHX; -.
DR   UniPathway; UPA00575; -.
DR   GO; GO:0004799; F:thymidylate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
DR   GO; GO:0006235; P:dTTP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.30.572.10; -; 1.
DR   HAMAP; MF_00008; Thymidy_synth_bact; 1.
DR   InterPro; IPR023451; Thymidate_synth/dCMP_Mease.
DR   InterPro; IPR000398; Thymidylate_synthase.
DR   InterPro; IPR020940; Thymidylate_synthase_AS.
DR   Pfam; PF00303; Thymidylat_synt; 1.
DR   PRINTS; PR00108; THYMDSNTHASE.
DR   SUPFAM; SSF55831; SSF55831; 1.
DR   TIGRFAMs; TIGR03284; thym_sym; 1.
DR   PROSITE; PS00091; THYMIDYLATE_SYNTHASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Methyltransferase; Nucleotide biosynthesis;
KW   Reference proteome; Transferase.
SQ   SEQUENCE   315 AA;  35789 MW;  E78B091B54F20BEC CRC64;
     MNKENIVPET IELPSQEKSG KEIAQHVNQD EFKYLKQVEQ ILQEGSRRDD RTGTGTISIF
     GMQSKYSLRN DTIPLLTTKR VYWKGVLEEL LWFISGSTDG KLLMAKNVKI WEKNGDRAFL
     DNLGFTSREE GDLGPVYGFQ WRHFGAKYVD CHTDYTGQGI DQLAEVIRQI KEEPDSRRII
     LSAWNPSELG QMVLPPCHTM CQFYVDNGEL SCQLYQRSGD MGLGVPFNLA SYGLLTHMIA
     KVCGLKAGTL VHTLGDAHVY SNHVDALKTQ MEREPYAFPK IRFTRDVSSI DDFTSDMIVL
     EDYKCHGKIV MDMAV
//
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